Study of Serum Lipid Profile in Cerebrovascular Diseases

Abstract

BACKGROUND Studies of cholesterol level in stroke patients have revealed results varying from insignificant changes to a moderate elevation. The meagre reports available in the Indian patients whose social living and dietary habits are different from western populations prompted us to study serum cholesterol and lipoprotein fraction in cerebrovascular disease. MATERIALS AND METHODS Present study was done to determine the serum lipid profile in 60 patients of cerebrovascular disease (44 with thrombotic stroke and 16 with haemorrhagic stroke) with a view to determine lipid abnormalities if any. 40 controls were also studied. In all cases, total cholesterol, serum LDL cholesterol, serum HDL cholesterol, serum VLDL cholesterol and serum triglycerides were estimated. RESULTS The total number of patients in Group-I were 44 with 12 females and 32 males. 13.6% of the patients with Thrombotic stroke and 25% of patients with Haemorrhagic stroke had serum cholesterol values greater than 240 mg%. Serum HDL Cholesterol lesser than 45% was seen in 54.54% patients of Thrombotic stroke and 25% patients of Haemorrhagic stroke. Comparison between female patients and female controls and male patients and male controls revealed significant difference in their mean cholesterol concentration. CONCLUSION The results obtained in the present study were positive for some groups of patient and negative for others. The results correlate with some of the previous studies and are in conflict with some studies.