Study of serum levels of CRP and procalcitonin as early marker of sepsis in children with sepsis above neonatal age group

Kumar, Vinaya; Neelannavar, Ramesh

doi:10.18203/2349-3291.ijcp20190037

Cited by 3 publications

(3 citation statements)

References 14 publications

(18 reference statements)

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“…Early identification of sepsis and prompt initiation of its therapy is the most important measure in reducing mortality from sepsis. Early identification of sepsis is difficult in children for many reasons, the clinical signs in children are very variable at the start of the infection; microbiological culture results are expected only after 48-72 hours; and false negative results are common [6]. In the current study, we found that concentrations were higher in septic patients than controls.…”

Section: Discussionmentioning

confidence: 44%

Diagnostic Value of Serum Leptin Level in Critically Ill Septic Child

Yazeed

Harkan

Ahmed

et al. 2020

JAMMR

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Introduction: Diagnosis of sepsis is important to reduce morbidity and mortality. Leptin is an important immunoregulatory hormone that enhances a number of immune responses in sepsis. Objective: to assess serum leptin in diagnosing sepsis in critically ill pediatric patients. Subjects and Methods: This study was carried out on 50 children divided into a case group included 40 critically ill patients initially sepsis free and fulfilling 2 of 4 criteria of SIRS admitted to the Pediatric Intensive Care Unit, children hospital, Tanta university and a control group included 10 apparently healthy children. According to the presence or absence of infection, our patients were classified into SIRS group and sepsis group. For all studied patients; serum leptin, CRP and others indicators of sepsis were measured at admission and 72h later, while were measured one time only for control group. Results: patients who developed sepsis had significantly higher serum leptin levels than those of the control group and SIRS (33.9 ± 20.8 vs. 1.9 ± 0.4, 21.5+ 10.1 respectively, p>0.05). Conclusion: Serum leptin may have a role in early diagnosis of sepsis.

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Section: Discussionmentioning

confidence: 44%

Diagnostic Value of Serum Leptin Level in Critically Ill Septic Child

Yazeed

Harkan

Ahmed

et al. 2020

JAMMR

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“…The predictors of mortality included positive blood cultures, multiorgan dysfunction, late hospital admissions, severe acute malnutrition, and the requirement of supportive care [9,13,19]. The predictors of progression to septic shock were abnormal leukocyte count, neutrophil, temperature, culture positivity, severe acute malnutrition, CRP, and PCT [5,6,19,26,27].…”

Section: Discussionmentioning

confidence: 99%

“…Sepsis caused by infection remains a major cause of mortality and morbidity among children. Blood culture though the gold standard requires a lot of time for diagnosis; hence, it is necessary to rely on early diagnostic markers such as blood counts, CRP, and PCT [26]. CRP and PCT were the inflammatory markers for patients with clinically suspected sepsis.…”

Section: Discussionmentioning

confidence: 99%

Sepsis in Children with Acute Lymphoblastic Leukemia

Aisyi

Dwijayanti

Wigati

et al. 2020

Indonesian Journal of Cancer

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Background: Sepsis is the leading cause of morbidity and mortality in children worldwide, with around 75,000 inpatients each year and nearly 50% dying in pediatric hospitals. Acute lymphoblastic leukemia (ALL) in childhood is a malignancy originating from lymphoid progenitor cells, usually at the age of 2–6 years. Children with ALL contribute 30% to childhood cancer cases under 15 years old. Sepsis in pediatric patients increases mortality significantly. A previous study showed that the prevalence of sepsis in pediatrics is still high. Thus, this study aims to report ALL patients with sepsis in our institution.Methods: This study was a descriptive cross-sectional study at the National Cancer Center (NCC) - Dharmais Cancer Hospital. We recruited acute lymphoblastic leukemia (ALL) patients aged 2-18 years with suspected or documented sepsis based on Systemic Inflammatory Response Syndrome (SIRS) by The International Consensus Conference on Pediatric Sepsis. The data were collected by medical records from January 2014 to December 2018.Results: A total of 94 pediatric patients in the study included 57 males and 37 females with an average age of 5 years. The age range was 1–18 years with a median age of 5 years. The prevalence of sepsis in pediatric with ALL was 11 patients (11.7%) and 45.5% of deaths. The clinical conditions were as follows: abnormal temperature (8 [72.7%]), abnormal blood pressure, systolic (7 [63.6%]) and diastolic (7 [63.6%]), abnormal pulse rate (9 [81.8%]), abnormal respiratory rate (8 [72.7%]), and normal saturation (6 [54.5%]). We also did a laboratory check followed by all sepsis patients who had abnormal leukocytes (11 [100%]), and abnormal lymphocytes count (8 [72.7%]).Conclusions: The mortality rate and prevalence of sepsis in children with ALL in our institution are still high. Further prospective studies are required to explore the risk factors and predictors of sepsis based on its severity and adherence of health workers to implement guidelines on patients with sepsis in the hospital.

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Biomarkers of Growth Faltering and Neurodevelopmental Delay in Children who are HIV-Exposed but Uninfected: A Systematic Review

Hawkes

Sirajee

Brophy

et al. 2023

CHR

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Introduction: Children who are HIV-exposed but uninfected (CHEU) are at risk of linear growth faltering and neurodevelopmental delay. Circulating biomarkers associated with these adverse outcomes may elucidate pathways of injury. Objective: To identify biomarkers associated with growth faltering and neurodevelopmental delay in CHEU. Methods: We performed a systematic review of electronic databases MEDLINE (1946-April 2021), EMBASE (1974-April 2021), Scopus (2004-April 2021), and PubMed (1985-April 2021), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO, registration number CRD42021238363). Results: We found seven studies associating biomarker abnormalities and growth outcomes in CHEUs and two studies on biomarker abnormalities and neurodevelopmental delay. Biomarker abnormalities associated with growth restriction were: C-reactive protein (CRP), tumour necrosis factor (TNF), interferon-gamma (IFN-γ), interleukin (IL)-12p70, IFN-γ-induced protein-10 (CXCL10/IP-10), lipopolysaccharide binding protein (LBP), insulin-like growth factor-1 (IGF-1), and IGF-binding protein-1 (IGFBP-1). Biomarkers associated with motor, language, and cognitive delay were CRP, IFN-γ, IL-1β, -2, -4, -6, -10, -12p70, neutrophil gelatinase-associated lipocalin (NGAL), granulocyte-macrophage colony-stimulating factor (GM-CSF), and matrix metalloproteinase-9 (MMP-9). Conclusion: Elevated markers of inflammation (acute phase reactants, pro-inflammatory cytokines, chemokines) and intestinal microbial translocation are associated with growth faltering. Elevated markers of inflammation are associated with adverse neurodevelopment.

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Study of serum levels of CRP and procalcitonin as early marker of sepsis in children with sepsis above neonatal age group

Cited by 3 publications

References 14 publications

Diagnostic Value of Serum Leptin Level in Critically Ill Septic Child

Diagnostic Value of Serum Leptin Level in Critically Ill Septic Child

Sepsis in Children with Acute Lymphoblastic Leukemia

Biomarkers of Growth Faltering and Neurodevelopmental Delay in Children who are HIV-Exposed but Uninfected: A Systematic Review

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