Abstract:Background
Down syndrome (DS) is a chromosomal disease in which all or part of a third copy of chromosome 21 is present. From the age of 6–9 months postnatal, endogenous growth hormone induces the production of insulin-like growth factor 1 (IGF-1), which has a significant influence on development. As a result, when growth hormone takes over as the primary regulator of development, the growth retardation associated with DS becomes more apparent.
Aim
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