Study of serum IgE levels in childhood asthma in Barabanki region, India

Rathoria, Ekansh; Bansal, Utkarsh; Gupta, Abhishek; Gupta, Nyay Bhai; Ahuja, Ravindra; Rathoria, Richa

doi:10.18203/2349-3291.ijcp20183369

Cited by 6 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority (n=56, 80%) cases showed IgE level >150IU/ml, and the mean total IgE was 800.9 ± 883.2IU/ml. This is similar to the study by Rathoria et al who reported the mean IgE levels in childhood asthma to be 881.81IU/ml [13]. This is consistent with previous reports suggesting serum IgE be characteristics of most allergic diseases including asthma [14][15][16].…”

Section: Discussionsupporting

confidence: 92%

Prevalence of Allergic Sensitization in Childhood Asthma

Meher¹,

Pradhan²,

Mahar³

et al. 2021

Cureus

View full text Add to dashboard Cite

The allergic sensitization in childhood asthma is common and the prevalence varies in different geographical locations. The data on allergen sensitization to guide clinicians on allergy avoidance is limited. MethodThis prospective observational study was conducted between October 2019 and April 2020 on children aged two to 14 years attending an outpatient clinic. Those with recurrent wheezing or physician-diagnosed asthma were interviewed; eosinophil count, total serum immunoglobulin E (IgE) was measured; and skin prick test (SPT) was done using standardized reagents. Wheal size of ≥3mm was considered positive. ResultsA total of 80 children were enrolled. The mean age was 71.15 ± 33.52 months (M:F ratio =1.96:1). Allergic rhinitis, conjunctivitis, and dermatosis were seen in 76 (95.0%), 33 (41.3%), and 22 (27.5%) cases, respectively. The mean absolute eosinophil count was 576 ± 427per cmm. The mean total IgE was 800.9 ± 883.2IU/ml. Seasonal and diurnal variations were found in 34 (42.5%) and 79 (98.8%) cases. Out of 1753 skin pricks using 27 reagents, 355 (20.25%) were positive. Increasing age was significantly associated with increasing SPT positivity (P = 0.0001). The most common sensitive aeroallergens were Kentucky bluegrass (25%), Dermatophagoides pteronyssinus (22.5%), Dermatophagoides farinae (21.3%), Timothy grass, and Alternaria alternans (20% each). The most common sensitive food allergens were spinach (25%), banana (22.5%), carp (20%), shrimp and hen's egg (18.8% each), and cow's milk (17.5%). ConclusionIncreasing age was associated with increasing SPT positivity in childhood asthma. The most common sensitive aeroallergens were Kentucky bluegrass and Dermatophagoides pteronyssinus; spinach and banana were the most common food allergen.

show abstract

Section: Discussionsupporting

confidence: 92%

Prevalence of Allergic Sensitization in Childhood Asthma

Meher¹,

Pradhan²,

Mahar³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…It has been noted that the mean serum tIgE levels in children with asthma was significantly higher than those in normal controls (p value <0.001). [16][17][18][19] In this study serum tIgE levels were above the normal limit for age in 86.2% patients with asthma. Chandran et al, Chaudhary et al, and Lama et al, found raised serum tIgE levels in 75% ,71.4% and 63.3% of asthmatic children respectively.…”

Section: Discussionmentioning

confidence: 87%

Serum immunoglobulin E and absolute eosinophil count as markers of severity in childhood asthma

Trivedi¹,

Patel²

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Asthma is a chronic inflammatory condition of the airways resulting in increased airway reactivity to a variety of stimuli like allergens, irritants, viruses and exercise. There is a strong association between the exposure of allergens and development of asthmatic symptoms. A hypersensitivity reaction initiated by immunologic mechanisms mediated by Immunoglobulin E (IgE) antibodies occurs in allergic asthma. IgE and eosinophils play an important role in the inflammatory process resulting in bronchial hyperresponsiveness. The aim of this study was to evaluate serum total IgE levels and Absolute Eosinophil Count (AEC) as markers of disease activity and study their association with the severity of bronchial asthma in children.Methods: A prospective study was conducted in the paediatric department of a tertiary care hospital in Ahmedabad, Gujarat, India from July 2017 to December 2018. Children between 4-14 years of age diagnosed as having bronchial asthma were included in the study. Serum total IgE levels and absolute eosinophil count were done in all the study participants and their correlation with the severity of asthma was assessed.Results: Of the total 109 patients of asthma, 44(40.4%) had intermittent asthma, 30(27.5%) mild persistent, 25(22.9%) moderate persistent and 10(9.2%) severe persistent asthma. Serum total IgE levels were raised above the normal limits for age in 94(86.2%) patients and increased AEC was found in 61(56 %) patients. Both serum total IgE levels and AEC increased significantly (p<0.0001) with increasing severity of asthma.Conclusions: Serum total IgE levels and AEC can be used to predict the severity of asthma in children.

show abstract

“…903,906,[908][909][910][911][912] Mean value of total IgE based on Indian Studies is varies from 65-128 IU/mL in non-atopic population and 269-1136 IU/m L in atopic population. 845,867,[912][913][914][915][916][917] Majority of Indian studies are hospital-based compared to studies conducted overseas. The Euro-Prevall INCO study on prevalence of food sensitization and probable food allergy among adults in India 923 reported that the mean value of total IgE was 529IU/L.…”

Section: Q 15 What Are Indications For Intradermal Testing In Respira...mentioning

confidence: 99%