Study of serum homocysteine level in cases of non-diabetic ischemic stroke

Murmu, Malati; Mahesh, K P Karun; Dash, Sanjay; Singh, Lagendra Kumar; Kar, A; Mishra, P. K.

doi:10.18203/2320-6012.ijrms20181433

Cited by 2 publications

(5 citation statements)

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“…An abrupt increase in serum homocysteine in women after 50 years suggests that sex difference in serum homocysteine levels disappears with increasing age. 3 In the present study, mean homocysteine level was significantly higher in hyperhomocysteinemia group (32±14.22) compared to normal homocysteine group (7.92±3.61) (p<0.05). Out of 32 patients with hyperhomocysteinemia, patients with ischemic stroke were 27 (84%) and that with CVT and hemorrhagic stroke were 4 (13%) and 1 (3%), respectively.…”

Section: Discussionsupporting

confidence: 45%

“…15 Total plasma homocysteine levels is comprised of about 70% of the homocysteine bound to albumin, 30% oxidized to disulphides and approximately 1% is present as free homocysteine. 3 Folic acid and B vitamins are needed for homocysteine metabolism as a substrate. Low serum folic acid and B vitamin levels may lead to rise of homocysteine levels in blood and vice versa.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Stroke is identified as an abrupt onset of a neurological deficit which can be attributed to a focal vascular cause. 3 Currently, many risk factors have been identified for stroke and modification of these factors is of prime importance for its primary and secondary prevention. 4 Stroke in young patients is a major health problem.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, as compared to concentrations below 9μM/l, there is nine-fold increase in the risk of myocardial infarction and stroke with total plasma homocysteine levels above 20 μM/l. 3 It has been cited in the literature that elevated serum homocysteine is an independent risk factor for the progress of atherosclerotic vascular disease processes, which is responsible for cardiovascular disease (CVD) and stroke, but a causal relationship between both is not yet definitely established. 7,8,10 Raised levels of total serum homocysteine are responsible for impairment of endothelial function and intensification of thrombosis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical profile and serum homocysteine level in young patients with stroke: a prospective, observational study

2019

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Background: According to the WHO, stroke is the second most important cause of death in elderly people with age >60 years and fifth leading cause in the age group of 15 to 59 years. Hyperhomocysteinemia has been linked to increased incidence of ischemic strokes. Thus, the aim of the present study was to assess serum homocysteine levels as an individual risk factor of stroke in young patients.Methods: This was a prospective, cross-sectional, single center study performed in 50 patients admitted in the Department of Medicine, Thanjavur Medical College and Hospital, Thanjavur, over a period of 7 months (i.e., from December 2013 to June 2014). Young patients, aged 1545 years, and diagnosed with stroke were included in the study. Serum homocysteine was measured by fluorescein polarization immunoassay (FPIA). Significant difference between the patients with normal and elevated mean serum homocysteine levels was identified by using unpaired t-test. P value ≤0.05 was considered as statistically significant.Results: Majority of the stroke patients were male (78%). Similarly, male patients dominated the total number of patients with elevated serum homocysteine levels (75%). Thirty-two (64%) patients had an elevated serum homocysteine level. There was a significant difference between the patients with increased homocysteine levels as compared to patients with normal homocysteine levels (p value <0.05). Out of 32 patients with hyperhomocysteinemia, 27 (84.38%) patients had ischemic stroke, 4 (12.50%) had cortical vein thrombosis and 1 (3.12%) had hemorrhagic stroke.Conclusions: Findings of the present study confirm that hyperhomocysteinemia is associated with an increased incidence of stroke in young patients. As healthcare providers, we must stress on prevention of stroke, especially by identifying treatable risk factors.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical profile and serum homocysteine level in young patients with stroke: a prospective, observational study

2019

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“…Elevated homocysteine content is currently considered as an independent risk factor for the development of cardiovascular diseases (Afonasyeva 2019). Hyperhomocysteinemia is also noted in stroke (Murmu et al 2018) and other pathological conditions, causing the development of ED.…”

Section: Markers Of Endothelial Dysfunction In Various Diseasesmentioning

confidence: 99%

Endothelial dysfunction: developmental mechanisms and therapeutic strategies

Shcheblykin¹,

Bolgov²,

Pokrovsky³

et al. 2022

RRP

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Introduction: Every year the importance of the normal functioning of the endothelial layer of the vascular wall in maintaining the health of the body becomes more and more obvious. The physiological role of the endothelium: The endothelium is a metabolically active organ actively involved in the regulation of hemostasis, modulation of inflammation, maintenance of hemovascular homeostasis, regulation of angiogenesis, vascular tone, and permeability. Risk factors for the development of endothelial dysfunction: Currently, insufficient bioavailability of nitric oxide is considered the most significant risk factor for endothelial dysfunction. Mechanisms of development of endothelial dysfunction: The genesis of endothelial dysfunction is a multifactorial process. Among various complex mechanisms, this review examines oxidative stress, inflammation, hyperglycemia, vitamin D deficiency, dyslipidemia, excess visceral fat, hyperhomocysteinemia, hyperuricemia, as well as primary genetic defect of endotheliocytes, as the most common causes in the population underlying the development of endothelial dysfunction. Markers of endothelial dysfunction in various diseases: This article discusses the main biomarkers of endothelial dysfunction currently used, as well as promising biomarkers in the future for laboratory diagnosis of this pathology. Therapeutic strategies: Therapeutic approaches to the endothelium in order to prevent or reduce a degree of damage to the vascular wall are briefly described. Conclusion: Endothelial dysfunction is a typical pathological process involved in the pathogenesis of many diseases. Thus, pharmacological agents with endothelioprotective properties can provide more therapeutic benefits than a drug without such an effect.

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Study of serum homocysteine level in cases of non-diabetic ischemic stroke

Cited by 2 publications

References 10 publications

Clinical profile and serum homocysteine level in young patients with stroke: a prospective, observational study

Clinical profile and serum homocysteine level in young patients with stroke: a prospective, observational study

Endothelial dysfunction: developmental mechanisms and therapeutic strategies

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