Study of septal stimulation and ablation in the macaque monkey

Votaw, Charles L.

doi:10.1212/wnl.10.2.202

Cited by 89 publications

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“…Hyper-reactivity has also been found in the rabbit following combined septal and hippocampal damage (Green & Arduini, 1954), in the cat after destruction of the septum (Spiegel et al, 1940) and in humans with tumours of the septum pellucidum (Zeman & King, 1958). However, as Rosner (1970) has indicated, this emotionality may be specific to particular species, for septal rage has not been found in the golden hamster (Sodetz et al, 1967), macaque monkey (Votaw, 1960) or the squirrel monkey (Buddington et al, 1967). Moreover, several experiments have failed to produce septal rage consistently in rats (Burkett & Bunnell, 1966;Clody & Carlton, 1969;Fried, 1969;Krieckhaus et al, 1964;Thomas et al, 1959;Thomas & Van Atta, 1972) or cats (Bond et al, 1957;Kling et al, 1960;Moore, 1964;McCleary, 1966).…”

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“…Stimulation of various areas of the septum of the cat (Siegel & Skog, 1970) suppressed the latency of hypothalamic elicited attack but increased the tendency for hypothalamic-produced hissing and freezing. Based on their own results and on the finding that septal stimulation results in decreased spontaneous activity in the lateral hypothalamic nucleus and increased activity in the ventromedial nucleus (Oomura et al, 1967), Siegel & Skog (1970) postulated that the septum plays a role in the regulations of aggressive behaviour by inhibiting the lateral hypothalamic nucleus which, when stimulated, elicits a biting attack (Wasman & Flynn, 1962).…”

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The Septum and Hyper‐reactivity: A Review

Fried

1973

British J of Psychology

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The literature related to one form of septal dysfunction ‐ hyper‐reactivity ‐ is reviewed. The increase in reactivity following septal damage is considered in terms of its reliability and the many factors which influence its attenuation and release. Research discussed includes the topics of anatomical locus of septal damage, species and strain investigated, pre‐ and post‐operative handling, neurochemical factors, and the relationship of hyper‐reactivity to other septal dysfunctions and other anatomical structures.

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The Septum and Hyper‐reactivity: A Review

Fried

1973

British J of Psychology

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“…The central projections as well as the peripheral input to the septum, described in the present study, play undoubtedly an important role in its various regulatory activities and particularly those concerned with affec tive behavior and emotional expression [23].…”

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confidence: 66%

Electrophysiological Studies of Somatosensory Projections to the Septum of the Cat

Feldman¹,

Hayat²

1973

Stereotact Funct Neurosurg

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Evoked potentials were recorded in the various septal nuclei of cats under chloralose anesthesia, following sciatic nerve stimulation, and four types of responses which had both short and long latencies, were demonstrated. During the penetration of the septum, changes in amplitude, the appearance of new waves and phase reversals were found. A series of experiments were performed to determine the pathways which mediate the long latency responses to the septum. These experiments, which included the recording of evoked potentials in the hypothalamus, the study of neuronal recovery cycles as well as hypothalamic stimulations and lesions, have suggested that the impulses arrive by polysynaptic pathways to the medial forebrain bundle and from there are propagated to the septum, thus confirming anatomical observations. The septum has an important function in behavioral, autonomic and endocrine mechanisms and the described somatosensory projections and their interaction with central inputs play undoubtedly an important role in its regulatory activities.

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“…Cette dernigre apparalt comme un modulatenr de l'aetivit6 61ectrophysiologique de l'hippocampe [8b] ou une station-relai entre le m6senc6phale et l'hippocampe [47]. Les exp6rienees de stimulation 61ectrique rendent aussi compte de la multiplicit6 des connections de cette r6gion [3,11,12,21,29,37,44,46,58,61].…”

Section: Altdration Du Eomportement De ((Construction Du Terriers)unclassified

“…L'hyperr4activit5 consecutive aux 16sions septales est g6n@alement attribu6e soit s une sensibilit4 accrue au stimulus [52], soit s une inhibition d4ficiente de certaines r6actions motrices [61], ph~nom~ne earact@istique de la destruction du septum. L'extinction retard6e de ]a r6action de fuite traduit une habituation anormalement lente s l'Sgard d'une stimulation sensorielle, anomalie d6j~ d~crite dans les l~sions du syst~me septum-hippocampe [30].…”

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Alt�rations du comportement cons�cutives � des l�sions de la r�gion septale du Mulot sylvestre (Apodemus Sylvaticus L.)

Amacker

1970

Exp Brain Res

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Regu le 9 f6vrier, 1970 Septal Lesions in Apodemus Sylvaticus L.Ce travail a b6n6fici6 de l'appui du Fonds National Suissc de la Recherche Seientifique, cr6dit no 4383Summary. Lesions placed in the septum of wild mice (Apodemus Sylvaticus L.) result in a loss of the earth digging behaviour though the overall activity is increased during 15--20 days after the operation. Food intake and motricity are not impaired.If the animal is provided with an artificial nest including a door allowing to record the number of entries and exits one may observe that some of the animals are going in and out of that nest up to 100 times in 24 hours after they have been submitted to a septal lesion. Before having been operated the same animals were only coming in and out of the nest about ten times in 24 hours. This observation points to the fact that the rhythms of spontaneous activity are deeply altered after a septal lesion, due to inadequate inhibition.In most of the observed animals the impairement of the earth digging behaviour was proportional to the volume of tissue destroyed in the septum but on the other hand no correlations seems to exist between the size of the destroyed area and the increase of the overall activity after a septal lesion.The continuous and quantitative record of the overall activity of the free animal and the use of Nauta's technique for the histological control --already undertaken --are going to bring a better understanding of the neuroanatomical and physiological basis of the studied behaviours.

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Study of septal stimulation and ablation in the macaque monkey

Cited by 89 publications

References 0 publications

The Septum and Hyper‐reactivity: A Review

The Septum and Hyper‐reactivity: A Review

Electrophysiological Studies of Somatosensory Projections to the Septum of the Cat

Alt�rations du comportement cons�cutives � des l�sions de la r�gion septale du Mulot sylvestre (Apodemus Sylvaticus L.)

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