Study of selenium species distribution in biological tissues by size exclusion and ion exchange chromatagraphy inductively coupled plasma–mass spectrometry

Moreno, Pilar; Salgado, Sara García; Gutiérrez, Ana María; Pérez-Conde, M.C.; Cámara, Carmen

doi:10.1016/j.aca.2004.02.029

Cited by 66 publications

(33 citation statements)

References 34 publications

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“…12,25,[27][28][29] The digestion of the finely ground-Niboshi with papain gave at most a two-fold higher concentration of selenium than that by method #8, although the protein concentration in the extract increased eight-fold due to the enzymatic degradation.…”

Section: Resultsmentioning

confidence: 99%

“…12,13,[27][28][29]31,32) Such unidentified low-molecular-mass species may be ascribed to fish diets and/ or fish-specific metabolism. 33) More recently, a low-molecularmass selenium compound, selenoneine (2-selenyl-N α ,N α ,N α -trimethyl-L-histidine), was isolated from the blood of the bluefin tuna.…”

Section: Ion-pair Extraction and Mass Spectrometrymentioning

confidence: 99%

“…Most studies by chromatographic separation techniques using the limited standard materials could identify only several selenium species, while unidentified peaks of which their retention times were not consistent with those of the standard materials still need to be evaluated. 11) Although SeMet, selenocystine (SeCyst) and trimethylselenonium ion (TMS) were detected in fish and shellfish, 12) other organoselenium species are still unknown. Actually, water-soluble and low-molecular-mass selenium species other than SeCys and SeMet were found in many flat fish, such as plaice, but their chemical structures have not yet been elucidated.…”

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Characterization of Selenium Species in Extract from Niboshi (a Processed Japanese Anchovy)

Yoshida

Haratake

Fuchigami

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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Fish are selenium rich foodstuffs and a major selenium source for the Japanese population. Niboshi is processed from Japanese anchovy (Engraulis japonicus) and commonly used to prepare soup stock for Japanese dishes. In this study, we characterized selenium species in the Niboshi extract by ultrafiltration, ion-exchange chromatography and mass spectrometry. Selenium species in the Niboshi were more extractable by polar solvents (water and ethanol) than an apolar one (hexane) along with amino acids and proteinous species. Selenium in the water-extract from the Niboshi was mostly ascribed to organoselenium compounds with a molecular mass less than 5 kDa. Although selenoamino acids and selenoproteins and their fragments were involved in the extract, a large portion of the selenium species appeared to be low-molecular-mass organoselenium compounds other than selenoamino acids and their derivatives. Ion-exchange chromatographic separations revealed that most of the selenium species in the extract possess anionic and/or amphoteric characteristics. One of these selenium species from the Niboshi extract was detected at m/z 577 for 80 Se by mass spectrometry subsequent to ion-pair extraction.

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Section: Resultsmentioning

confidence: 99%

Section: Ion-pair Extraction and Mass Spectrometrymentioning

confidence: 99%

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Characterization of Selenium Species in Extract from Niboshi (a Processed Japanese Anchovy)

Yoshida

Haratake

Fuchigami

et al. 2012

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…17,22) Fish and shellfish are the major selenium sources for the Japanese population because of their higher selenium contents compared to plant foodstuffs and the higher consuming amount of seafood in the Japanese cuisine.…”

Section: )mentioning

confidence: 99%

“…21) Various seafood stuffs are reported to contain high concentrations of selenium, for example, 3.9 µg/g in tuna, and 2.2 µg/g in oyster. 17,22) Fish and shellfish are the major selenium sources for the Japanese population because of their higher selenium contents compared to plant foodstuffs and the higher consuming amount of seafood in the Japanese cuisine. 5) We previously reported that selenium in a processed Japanese anchovy of 5-7 cm length (Niboshi) was effective to restore the selenium content in the liver and the hepatic GPx activity of dietary selenium deficient mice.…”

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Characterization of Selenium Species in the Shijimi Clam

Yoshida

Koga

Iwataka

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Selenium is an essential trace element for humans and animals. Fish and shellfish are known to be rich in selenium and suppose to be an effective selenium source. In this study, we characterized the selenium species in the Shijimi clam (Corbicula japonica), which is a typical clam eaten in Japan. The Shijimi clam contains a relatively high concentration of selenium (3.5 µg-selenium/g-dry Shijimi). Approximately 30% of the total selenium in the Shijimi clam meat was extractable with water, while selenium in the Shijimi clam was hardly extracted with ethanol, chloroform and hexane. Based on an ultrafiltration study, the molecular mass of the major selenium species in the Shijimi water-extract was estimated to be less than 5000. Because amphoteric selenium species were contained in the Shijimi water-extract, which was indicated by ion-exchange chromatographic separation, an ion-pair reagent was utilized to extract the ionic selenium species into an organic solvent. A matrix assisted laser desorption ionization (MALDI) time of flight (TOF)-mass spectrometric analysis revealed the selenium isotopic pattern involving one selenium atom in a molecule with the 80 Se molecular ion peak at m/z 534. This selenium species was mainly found in the visceral part of the Shijimi clam by imaging mass spectrometry.Key words selenium; seafood; imaging mass spectrometry Selenium is an essential trace element for humans and animals.1) This element plays important roles as the active center of the selenocysteine (SeCys)-containing proteins (selenoproteins) in biological systems.2) Glutathione peroxidases (GPxs), the most abundant selenoproteins, catalyze the reduction of hydrogen peroxide and organic hydroperoxides into water and the corresponding alcohols using glutathione. The plasma GPx activity is commonly used to evaluate the individual selenium status.3) The WHO recommends taking 40 µg of selenium per day for adult men, which is the amount to achieve two-thirds of the maximum GPx activity of the plasma.4) The recommended dietary allowance for adults in Japan is 20-25 µg/d, and the actual amount of the mean selenium intake is reported to be approximately 100 µg/d in Japan.5) Cereals, meats, fishes and eggs are known to be rich in selenium.6,7) Miyazaki et al. reported that fish is the major selenium source for the Japanese population (more than 50% of daily intake).5) The bioavailability of selenium in foodstuffs is dependent not only on the selenium content, but also on the chemical form of this element. There have been many reports about the selenium role in cancer prevention. 8) On the contrary, a recent largescale trial to investigate the effect on prostate cancer risk by selenium and vitamin E revealed that 200 µg/d of seleno-Lmethionine (SeMet) did not reduce the cancer risk but raised the risk of type 2 diabetes.9,10) This may be partially attributed to the chemical form of the selenium being used. Therefore, a speciation analysis of selenium in foodstuffs and supplements has been performed in the past few decades. SeMet wa...

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Selenium: Inorganic ChemistryBased in part on the article Selenium: Inorganic Chemistry by Bernt Krebs, Stefan Bonmann, & Illenora Eidenschink which appeared in theEncyclopedia of Inorganic Chemistry, First Edition.

Atwood

2005

Encyclopedia of Inorganic Chemistry

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Selenium is the first member of the group 16 elements O, S, Se, Te, and Po that shows some metallic character. The increasing metallic character in the series O, S, Se, Te, Po is reflected also in the lower electronegativity, in the less acid character of the oxides, and in the lower stability of the oxidation number +VI for selenium compared to sulfur. There is a large variety of compounds of SeII, SeIV, and SeVI with the electronegative elements N, O, F, Cl, and Br. Thus, there are six general types of compounds, and these will comprise the main sections in the article. They are cations, halides, oxides, haloselenates, oxohaloselenates, and the related compounds that form when both selenium and nitrogen are present in the molecule.

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Study of selenium species distribution in biological tissues by size exclusion and ion exchange chromatagraphy inductively coupled plasma–mass spectrometry

Cited by 66 publications

References 34 publications

Characterization of Selenium Species in Extract from Niboshi (a Processed Japanese Anchovy)

Characterization of Selenium Species in Extract from Niboshi (a Processed Japanese Anchovy)

Characterization of Selenium Species in the Shijimi Clam

Selenium: Inorganic ChemistryBased in part on the article Selenium: Inorganic Chemistry by Bernt Krebs, Stefan Bonmann, & Illenora Eidenschink which appeared in theEncyclopedia of Inorganic Chemistry, First Edition.

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