Study of Sedative and Anxiolytic Effects of Herbal Extract Hypericum perforatum in Comparison with Diazepam in Rats

Rezaie, Ali; Dorostkar, K. Rezaee; Pashazadeh, Mehrdad; Nejad, Shahram Mohammad

doi:10.1016/j.ijid.2008.05.426

Cited by 13 publications

(13 citation statements)

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“…Finally, Malvaceae leads the ranking in troubles related to the nervous system and mental disorders (29.58%). The success in this use is basically explained by the genus Tilia (733 UR, 97.34%)—recently incorporated into the Malvaceae, where Tiliaceae have been merged—very popular and largely studied as hypnotic, sedative and tranquilizer [ 68 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Botanical Families in Medicinal Ethnobotany: A Phylogenetic Perspective

Gras

Hidalgo

D'Ambrosio³

et al. 2021

Plants

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Studies suggesting that medicinal plants are not chosen at random are becoming more common. The goal of this work is to shed light on the role of botanical families in ethnobotany, depicting in a molecular phylogenetic frame the relationships between families and medicinal uses of vascular plants in several Catalan-speaking territories. The simple quantitative analyses for ailments categories and the construction of families and disorders matrix were carried out in this study. A Bayesian approach was used to estimate the over- and underused families in the medicinal flora. Phylogenetically informed analyses were carried out to identify lineages in which there is an overrepresentation of families in a given category of use, i.e., hot nodes. The ethnobotanicity index, at a specific level, was calculated and also adapted to the family level. Two diversity indices to measure the richness of reported taxa within each family were calculated. A total of 47,630 use reports were analysed. These uses are grouped in 120 botanical families. The ethnobotanicity index for this area is 14.44% and the ethnobotanicity index at the family level is 68.21%. The most-reported families are Lamiaceae and Asteraceae and the most reported troubles are disorders of the digestive and nutritional system. Based on the meta-analytic results, indicating hot nodes of useful plants at the phylogenetic level, specific ethnopharmacological research may be suggested, including a phytochemical approach of particularly interesting taxa.

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Section: Resultsmentioning

confidence: 99%

The Role of Botanical Families in Medicinal Ethnobotany: A Phylogenetic Perspective

Gras

Hidalgo

D'Ambrosio³

et al. 2021

Plants

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“…Anxiety has been treated with benzodiazepines, as diazepam. Using interaction with brain receptors for GABA neurotransmitter, diazepam can provide the anxiolytic effect and also act as a sedative [133]. In the study by Abadi et al [132], administration of high doses of R. officinalis L. hydroalcoholic extract provided a similar effect to this drug.…”

Section: Stress Relief In Situation Of Real Dangermentioning

confidence: 99%

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

2019

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Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservative. R. officinalis L. is constituted by bioactive molecules, the phytocompounds, responsible for implement several pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, antiproliferative, antitumor and protective, inhibitory and attenuating activities. Thus, in vivo and in vitro studies were presented in this Review, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents. In this way, methodology, mechanisms, results, and conclusions were described. The main objective of this study was showing that plant products could be equivalent to the available medicines.

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“…5 Nowadays, medicinal plants have been used more because of appearing numerous properties of them such as anti-oxidant activities and physiological aspects of them including anti-cancer, anti-sensitivity and anti-diabetic properties, prevention of coronary artery blockage, and reducing cholesterol. 6 Reports exist about the Effect of flavonoids on benzodiazepines receptors. Extant flavonoids in medicinal plants cause tranquilizing, anti-anxiety effects via affecting benzodiazepine receptors binding to Gaba receptors.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ginger Extract and Diazepam on Anxiety Reduction in Animal Model

Fadaki¹,

Mahkam²,

Sajjadian³

2017

IJPER

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Objective: Anxiety disorders are from common disorders of human. Drug treatments have side effects, and searching new ways with fewer side effects is inevitable. Ginger is a medicinal plant with many therapeutic effects. Methods: In current study the effects of ginger extract and diazepam on anxiety reduction of laboratory mice were investigated. Sixty female mice (25-30g) were divided into six groups including control, anxiety, diazepam and 50, 100 and 200 mg/kg extract doses. After receiving the last dose, all groups except control group were placed in dark box to enforce anxiety. Next, anxiety evaluation test was carried out using plus elevated maze. The number of open and close arms were considered as anxiety indices. Results: According to results, ginger extract reduced anxiety in all doses in proportion to control and diazepam groups. Also, movement activity was increased in 200 mg/kg dose significantly (p<0.05). Conclusion: Therefore, ginger extract in 200 mg/kg dose can be an appropriate replacement for diazepam to reduce anxiety symptoms.

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Study of Sedative and Anxiolytic Effects of Herbal Extract Hypericum perforatum in Comparison with Diazepam in Rats

Cited by 13 publications

References 0 publications

The Role of Botanical Families in Medicinal Ethnobotany: A Phylogenetic Perspective

The Role of Botanical Families in Medicinal Ethnobotany: A Phylogenetic Perspective

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent

The Effects of Ginger Extract and Diazepam on Anxiety Reduction in Animal Model

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