Study of Saponins from<i>Glycyrrhiza glabra</i>Root

Varshney, I. P.; Jain, D. C.; Srivastava, H. C.

doi:10.3109/13880208309070637

Cited by 12 publications

(3 citation statements)

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“…The leaves, roots and rhizomes of licorice have been used traditionally for different purposes including wound healing ( Dafni et al, 1984 ), cough ( Fujita et al, 1995 ) cystitis ( Yarnell, 1997 ), tuberculosis ( Arseculeratne et al, 1985 ), gastric ulcer ( Varshney et al, 1983 ) and diabetes ( Rajurkar and Pardeshi, 1997 ). Licorice shows different pharmacological activities such as hepatoprotective ( Nakamura et al, 1985 ; Lin and Tome, 1988 ; Nose et al, 1994 ; Lin et al, 1999 ; Al-Qarawi et al, 2001 ; Jeong et al, 2002 ; Lee et al, 2009 ; Huo et al, 2011 ), anti-inflammatory ( Finney and Somers, 1958 ; Ohuchi and Tsurufuji, 1982 ; Yu et al, 2015 ; Yang et al, 2016 ), antiviral, antimicrobial ( Shebl et al, 2012 ; Sabouri Ghannad et al, 2014 ; Wang et al, 2015 ) and immunomodulatory effect ( Kimura et al, 1992 ; Tandon et al, 2002 ; Raphael and Kuttan, 2003 ).…”

Section: Glycyrrhiza Glabra Lmentioning

confidence: 99%

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

et al. 2017

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In many developing countries, jaundice is the common symptom of hepatic diseases which are a major cause of mortality. The use of natural product-based therapies is very popular for such hepatic disorders. A great number of medicinal plants have been utilized for this purpose and some facilitated the discovery of active compounds which helped the development of new synthetic drugs against jaundice. However, more epidemiological studies and clinical trials are required for the practical implementation of the plant pharmacotherapy of jaundice. The focus of this second part of our review is on several of the most prominent plants used against jaundice identified in the analysis performed in the first part of the review viz. Andrographis paniculata (Burm.f.) Nees, Silybum marianum (L.) Gaertn., Terminalia chebula Retz., Glycyrrhiza glabra L. and some species of genus Phyllanthus. Furthermore, we discuss their physiological effects, biologically active ingredients, and the potential mechanisms of action. Some of the most important active ingredients were silybin (also recommended by German commission), phyllanthin and andrographolide, whose action leads to bilirubin reduction and normalization of the levels of relevant serum enzymes indicative for the pathophysiological status of the liver.

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Section: Glycyrrhiza Glabra Lmentioning

confidence: 99%

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

et al. 2017

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“…It was also reported that daily oral administration of flavonoids (35 mg/kg, for 19-20 days), isolated from aerial parts of Scutellaria baicalensis Georgi, could reduce memory dysfunction and neuronal injury caused by permanent global ischemia in rats [ 38 ]. Another group of phytochemicals is saponins which are constituents of Anchusa italica [ 39 ] and Glycyrrhiza glabra [ 40 , 41 ]. Previous reports have demonstrated that they could be responsible for improvement of the learning impairment [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice

Amat

Hoxur

Dang

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Oral administration of Abnormal Savda Munsiq (ASMq), a herbal preparation used in Traditional Uighur Medicine, was found to exert a memory-enhancing effect in the chronic stressed mice, induced by electric foot-shock. The memory improvement of the stressed mice was shown by an increase of the latency time in the step-through test and the decrease of the latency time in the Y-maze test. Treatment with ASMq was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and β-endorphin (β-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ASMq was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT) and 3,4-dihydroxyphenylalanine (DOPAC). The results obtained from this study suggested that the memory-enhancing effect of ASMq was mediated through regulations of neurochemical and neuroendocrine systems.

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“…eicosanyl caffeate and docosyl caffeate possess potent elastase inhibitory activity, and moderate antioxidant activity [36]. Two saponins, glabranin-A and B, are glycosides of glycyrrhetic acid [113]. Oleanane-type triterpene saponins, licorice-saponin M3, licoricesaponin N4, and licorice-saponin O4, were isolated by Wei et al [119].…”

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confidence: 99%

Glycyrrhiza glabra L. (Fabaceae/Leguminosae)

Akbar

2020

Handbook of 200 Medicinal Plants

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Liquorice is a perennial, temperate-zone herb or subshrub, native of India, Pakistan and southern Europe; also cultivated in England, and Iraq. It has also been grown experimentally in the United States. Ancient historical manuscripts from China, India and Greece mention its use for symptoms of viral respiratory tract infections and hepatitis. The plant has also been described by Theophrastus. Licorice from Egypt has been described to be the best, followed by from Iraq and Syria; the root should be decorticated before use. It concocts viscid humours in diseases of liver, bladder and lungs, and expectorates them. It has been used in Iranian herbal medicine for skin eruptions, including dermatitis, eczema, pruritus and cysts, and for treatment of stomach disorders including peptic ulcers. The herb extract inhibits gastric motility in vivo, which is regarded to be an important aspect for its antiulcer activity. Licorice possesses both anti-inflammatory and antiulcer activities; whereas most antiinflammatory agents are ulcerogenic. Former German Commission E believed it to be effective in the treatment of atopic dermatitis. Licorice root has been used for years to regulate gastrointestinal function in TCM, has been used for generations as an antidote, demulcent, and elixir in folk medicine of China, and is the most commonly used crude drug in Kampo Medicines, the Japanese form of modified TCM, for the treatment of peptic ulcer. Roots contain glycyrrhizin, the main water-soluble constituent that is 50Â sweeter than sugar, 2-b-glucuronosyl glucuronic acid, and isoliquiritigenin-4-glucoside. Glycyrrhizin is a nonhemolytic saponin with foaming property, and one of the most potent hydroxyl radical scavengers. No significant effect of deglycyrrhizinised liquorice was observed on gastric ulcer in an RCT of British patients. Treatment of healthy men with licorice for one-week decreased salivary testosterone values by 26% but no significant decrease in free testosterone, and nine healthy women treated with licorice daily © Springer Nature Switzerland AG 2020 S. Akbar, Handbook of 200 Medicinal Plants, https://doi.org/10.1007/978-3-030-16807-0_103 963 for two cycles, had their mean total serum testosterone decreased by 37% at the end of 2nd month. This property could be useful as an adjunct therapy of hirsutism and PCOS.Description: Liquorice is a perennial, temperate-zone herb or subshrub, native of India, Pakistan and southern Europe; also cultivated in England,

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Study of Saponins fromGlycyrrhiza glabraRoot

Cited by 12 publications

References 3 publications

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families

Behavioral, Neurochemical and Neuroendocrine Effects of Abnormal Savda Munziq in the Chronic Stress Mice

Glycyrrhiza glabra L. (Fabaceae/Leguminosae)

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