Study of Role of Surfactant Protein-D, Malondialdehyde, Protein Carbonyl and its Correlation with Airflow Obstruction (FEV1% Predicted) in Patients with Smoker Chronic Obstructive Pulmonary Disease (COPD)

Pawar, Rupali; Abhang, Subhodini A

doi:10.4172/2161-1009.1000327

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…In this context, our observations that administration of cART is associated with significant decreases in the concentrations of ICAM-1, L-selectin, and IL-8 is consistent with systemic activation of these cells [50, 51] and a beneficial, albeit secondary, anti-inflammatory effect of therapy. This interpretation is supported by the observation that virally suppressive cART was also associated with a significant decrease in serum surfactant D, a biomarker of oxidative stress [52].…”

Section: Discussionmentioning

confidence: 73%

Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants

Steel

Venter

Theron

et al. 2018

Mediators of Inflammation

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Like HIV infection, smoking, which is common among HIV-infected persons, is associated with chronic, systemic inflammation. However, the possible augmentative effects of HIV infection and smoking and other types of tobacco usage on indices of systemic inflammation and the impact of combination antiretroviral therapy (cART) thereon remain largely unexplored and represent the focus of the current study. Of the total number of HIV-infected persons recruited to the study (n = 199), 100 were categorised as pre-cART and 99 as virally suppressed (HIV viral load < 40 copies/mL). According to serum cotinine levels, 144 and 55 participants were categorised as nonusers and users of tobacco, respectively. In addition to cytokines (IL-6, IL-8, and TNF-α) and chemokines (IP-10, MIG, IL-8, MCP-1, and RANTES), other biomarkers of systemic inflammation included C-reactive protein (CRP), β2-microglobulin, and those of neutrophil activation [ICAM-1, L-selectin, matrix metalloproteinase-9 (MMP-9)], microbial translocation (soluble CD14, LPS-binding protein), and oxidative stress (cyclophilin A, surfactant D). These were measured using multiplex bead array, ELISA, and immunonephelometric procedures. Viral suppression was associated with significant decreases in the levels of most of the biomarkers tested (P < 0.0037-0.0008), with the exceptions of CRP, cyclophilin A, and MMP-9. With respect to tobacco usage, irrespective of cART status, circulating levels of β2-microglobulin, cyclophilin A, and RANTES were significantly elevated (P < 0.042-0.012) in users vs nonusers. Additional analysis of the groups of tobacco users and nonusers according to cART status revealed high levels of RANTES in pre-cART/tobacco users relative to the three other subgroups (P < 0.004-0.0001), while more modest increases in cyclophilin A and MMP-9 (P < 0.019-0.027) were observed in comparison with the cART/tobacco user subgroup. Notwithstanding the efficacy of cART in attenuating HIV-associated, chronic systemic inflammation, the current study has identified RANTES as being significantly and seemingly selectively increased in those with active HIV infection who use tobacco, a mechanism which may underpin augmentative proinflammatory activity.

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Section: Discussionmentioning

confidence: 73%

Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants

Steel

Venter

Theron

et al. 2018

Mediators of Inflammation

View full text Add to dashboard Cite

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Study of Serum Surfactant Protein D Levels in Chronic Obstructive Pulmonary Disease Patients

Tiwari,

Fatima,

Gowardipe

2023

Medical Journal of Dr. D.Y. Patil Vidyapeeth

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Background: An increasing prevalence of chronic obstructive pulmonary disease (COPD) worldwide is one of the major reasons for morbidity and mortality. Surfactant protein D (SP-D) has been identified to have a role in the host defence system of the lungs and regulation of surfactant homeostasis. SP-D is considered as a biomarker of ascertaining the severity of COPD and risk of future exacerbations. Objectives: This study aimed to investigate changes in lung functions and SP-D levels in COPD patients for early diagnosis and timely intervention to prevent progression of the disease. Methods: One hundred stable COPD patients were enrolled for the study and were compared to 100 normal healthy individuals of the same age. Those fulfilling the inclusion and exclusion criteria were enrolled for the study. Pulmonary function tests were performed via spirometry. Blood samples were collected and estimation of SP-D was done using enzyme-linked immunosorbent assay (ELISA). Results: The observation revealed a significant decline in ventilatory functions with increasing severity of COPD, as reflected by the decrease in FEV1% and FEV1-to-FVC ratio compared to controls (P < 0.001). Serum SP-D levels were significantly increased in COPD patients (P < 0.001) compared to controls. Conclusion: SP-D estimation in COPD patients helps in monitoring the progression and prognosis of the diseases; formulate strategies for early therapeutic intervention to prevent risk of exacerbations to improve quality of life.

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Studies on the Activity of Some Biocompounds Relevant in Food and Clinical Domain

Pisoschi¹

2017

Biochem Anal Biochem

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Study of Role of Surfactant Protein-D, Malondialdehyde, Protein Carbonyl and its Correlation with Airflow Obstruction (FEV1% Predicted) in Patients with Smoker Chronic Obstructive Pulmonary Disease (COPD)

Cited by 3 publications

References 27 publications

Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants

Effects of Tobacco Usage and Antiretroviral Therapy on Biomarkers of Systemic Immune Activation in HIV-Infected Participants

Study of Serum Surfactant Protein D Levels in Chronic Obstructive Pulmonary Disease Patients

Studies on the Activity of Some Biocompounds Relevant in Food and Clinical Domain

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