Study of Risk Factors for ST Segment Elevation Myocardial Infarction and it’s Correlation With Thyroid Functions ProfileStudy of Risk Factors for ST Segment Elevation Myocardial Infarction and it’s Correlation With Thyroid Functions Profile

Abstract

Background:To assess the occurrence of risk factors in patients with STEMI with special reference to Thyroid functions and Thyroid profile (Hypothyroidism/ Hyperthyroidism). Methods: A total of 140 patients diagnosed with ST segment elevation myocardial infarction (STEMI) admitted to ICU/CCU of NIMS Medical College & Hospital over the period of 18 months (june 2016 -november 2017) will be included in the study and subsequently evaluated for presence of risk factors and thyroid dysfunction. Majority of subjects belonged to rural areas located near to the hospital of either sex above the age of 18 years. On the basis of history, clinical examination, inclusion and exclusion criteria of the study, subjects were selected. It is an observational cross-sectional study. Statistical analysis were done using Fisher test, student 't' test and Chi-Square test. 'p' value less than 0.05 is taken as significant. Results: Out of 140 patients with STEMI, 20 patients had thyroid dysfunction while 120 patients had euthyroid status. Subclinical hypothyroidism were reported in 12 (8.6%) patients while Hypothyroidism were noticed in 4 (2.9%) patients. Subclinical hyperthyroidism and Hyperthyroidism were observed in 3 (2.1%) and 1( 0.7%) patients, respectively. Out of 140 patients with STEMI, 2 patients with euthyroid status died while 8 patients with thyroid dysfunction died with p=0.001 which was statistically significant Conclusion: Thyroid dysfunction significantly increases relative risk of mortality as compared to euthyroid function in patients with STEMI.