Study of Risk Factors and Clinical Profile of Stroke in Young Adults

Jadhav, Yogesh L.; Bondarde, Shailesh Arjun

doi:10.18311/mvpjms/2015/v2/i1/791

Cited by 2 publications

(1 citation statement)

References 11 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have included 61 studies in our systematic review, conducted across various states in India, estimating the various lifestyle risk factors for stroke ( Table 1 ). 13 – 73 Out of 61, 56 studies were conducted and 58 were published after 2000. In 51 studies, patients were enrolled from the hospital-based stroke registries (HBSR) maintained in various treatment settings across India, while in 10 studies, the enrollment was using population-based stroke registries (PBSR).…”

Section: Resultsmentioning

confidence: 99%

The Distribution of Lifestyle Risk Factors Among Patients with Stroke in the Indian Setting: Systematic Review and Meta-Analysis

Varkey

Joseph

Varghese

et al. 2022

Annals of Neurosciences

View full text Add to dashboard Cite

Background The burden of stroke is increasing in India, but there is limited understanding of the distribution of reported risk factors in the Indian setting. It is vital to generate robust data on these modifiable risk factors to scale up appropriate strategies for the prevention of cerebrovascular diseases in this setting. Summary The objective of this study is to estimate the overall proportion of life style risk factors of patients with stroke in the Indian setting. We searched PubMed and Google Scholar and relevant studies published till February 2022 were included. The risk of bias assessment was considered for the study selection criterion in the meta-analysis. The publication bias was evaluated by funnel plots and Egger’s test. We identified 61 studies in the systematic review and after quality assessment, 36 studies were included for meta-analysis. Random effect model was used due to the significant inconsistency among the included studies (I2 > 97%). The mean age of the participants was 53.84±9.3 years and patients with stroke were predominantly males (64%). Hypertension (56.69%; 95% CI: - 48.45 – 64.58), obesity (36.61%; 95% CI: - 19.31 – 58.23), dyslipidemia (30.6%; 95% CI: - 22 – 40.81) and diabetes mellitus (23.8%; 95% CI: - 18.79 – 29.83) are the leading intermediate conditions associated with stroke. The Physical inactivity - 29.9% (95% CI: - 22.9 – 37.1), history of tobacco use (28.59 %; 95% CI: - 22.22 – 32.94) and alcohol use (28.15 %; 95% CI: - 20.49 – 37.33) were reported as the behavioral risk factors for stroke in this setting. Key Messages The current meta-analysis provides robust estimates of the life style related risk-factor of stroke in India based on the observational studies conducted from 1994 to 2019. Estimating the pooled analysis of stroke risk factors is crucial to predict the imposed burden of the illness and ascertain the treatment and prevention strategies for controlling the modifiable risk factors in this setting.

show abstract

Section: Resultsmentioning

confidence: 99%

The Distribution of Lifestyle Risk Factors Among Patients with Stroke in the Indian Setting: Systematic Review and Meta-Analysis

Varkey

Joseph

Varghese

et al. 2022

Annals of Neurosciences

View full text Add to dashboard Cite

show abstract

Age, gender, and regional variations in stroke epidemiology in India: A systematic review and meta-analysis

Joseph,

Varkey,

Varghese

et al. 2024

Indian Journal of Community and Family Medicine

View full text Add to dashboard Cite

Introduction: There is a wide variation in stroke epidemiology in India due to the differences in culture and the variability in the distribution of risk factors across the states. The present meta-analysis provides a pooled estimate of age, gender, and region-based stroke epidemiology in India based on epidemiological transition level (ETL) groups described in the Global Burden of Disease (GBD) Study (2016). Methods: We searched in PubMed and Google Scholar, and relevant studies published till February 2022 were included. Observational studies conducted in the Indian setting were included and global or Indian studies that exclusively estimated the prevalence, incidence, or mortality data among patients with stroke were excluded. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used for the risk-of-bias assessment and publication bias was evaluated by funnel plots and Egger’s test. The R software was used to perform this meta-analysis; I2 statistics were calculated to measure heterogeneity among studies. Results: We included 58 studies in the systematic review, and after quality assessment, 47 studies were finally included for meta-analysis. The sample sizes of the included studies ranged from 40 to 4989 and the mean age of the participants ranged from 31.7 (Standard Deviation, SD-7.4) to 70.5 (SD-10.7). The burden of stroke was estimated based on the ETL groups described in the GBD Study 2016. We found a male preponderance (64.5%; 95% confidence interval [CI]: 62.5%-68.3%) in the gender distribution of strokes and 75.2% (95% CI: 68.7%-81.7%) of the stroke occurred above the age of 50 years. Ischemic stroke is the predominant subtype of stroke in India, with a higher proportion in the middle ETL region (74.0%; 95% CI: 65.1%-81.3%) as compared to those with low ETL (67.2%; 95% CI: 49.9%-80.8%) and high ETL regions (67.5%; 95% CI: 57.0%-76.4%). Conclusion: There was a significant heterogeneity among the included studies. Majority of strokes occurred in the age group of more than 50 years with a male preponderance. Ischemic stroke was the most common type of stroke with its proportion varying from 67% to 74% depending on ETL. PROSPERO Registration: CRD42022316774.

show abstract

Study of Risk Factors and Clinical Profile of Stroke in Young Adults

Cited by 2 publications

References 11 publications

The Distribution of Lifestyle Risk Factors Among Patients with Stroke in the Indian Setting: Systematic Review and Meta-Analysis

The Distribution of Lifestyle Risk Factors Among Patients with Stroke in the Indian Setting: Systematic Review and Meta-Analysis

Age, gender, and regional variations in stroke epidemiology in India: A systematic review and meta-analysis

Contact Info

Product

Resources

About