Study of retrieved acetabular sockets made from high-dose, cross-linked polyethylene

Oonishi, Hironobu; Clarke, Ian C.; Masuda, Shingo; Amino, Hirokazu

doi:10.1054/arth.2001.28371

Cited by 32 publications

(18 citation statements)

References 3 publications

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“…Concurrently, polyethylene researchers at multiple institutions around the world confirmed the finding that elevated doses of radiation crosslinking would reduce wear rates by an order of magnitude during in vitro hip simulator testing [95,103,133]. Clinical researchers in Japan and South Africa reported successful long-term case series initiated in the 1970s in which polyethylene had been exposed to elevated doses of gamma radiation [56,109,111] and silane chemistry [144]. Researchers also found thermal processing after radiation could influence the mechanical properties and oxidative resistance of the polymer [95,103].…”

Section: History and Development Of Hxlpementioning

confidence: 85%

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

Kurtz

Gawel

Patel

2011

Clinical Orthopaedics &Amp; Related Research

407

282

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Background Highly crosslinked polyethylene (HXLPE) was introduced to reduce wear and osteolysis in total joint arthroplasty. While many studies report wear and osteolysis associated with HXLPE, analytical techniques, clinical study design and followup, HXLPE formulation and implant design characteristics, and patient populations differ substantially among investigations, complicating a unified perspective. Questions/purposes Literature on first-generation HXLPE was summarized. We systematically reviewed the radiographic wear data and incidence of osteolysis for HXLPE in hip and knee arthroplasty. Methods PubMed identified 391 studies; 28 met inclusion criteria for a weighted-averages analysis of two-dimensional femoral head penetration rates. To determine the incidence of osteolysis, we estimated a pooled odds ratio using a random-effects model.Results Weighted-averages analyses of femoral head penetration rates in HXLPE liners and conventional UHMWPE liners resulted, respectively, in a mean twodimensional linear penetration rate of 0.042 mm/year based on 28 studies (n = 1503 hips) and 0.137 mm/year based on 18 studies (n = 695 hips). The pooled odds ratio for the risk of osteolysis in HXLPE versus conventional liners was 0.13 (95% confidence interval, 0.06-0.27) among studies with minimum 5-year followup. We identified two clinical studies of HXLPE in TKA, preventing systematic analysis of outcomes. Conclusions HXLPE liner studies consistently report lower femoral head penetration and an 87% lower risk of osteolysis. Reduction in femoral head penetration or osteolysis risk is not established for large-diameter ([ 32 mm) metallic femoral heads or ceramic femoral heads of any size. Few studies document the clinical performance of HXLPE in knees.

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Section: History and Development Of Hxlpementioning

confidence: 85%

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

Kurtz

Gawel

Patel

2011

Clinical Orthopaedics &Amp; Related Research

407

282

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“…1). Previous studies report gamma-sterilized PE containing free radicals degrade with substantial oxidation in vivo [10,11,18]. We found the oxidation index of the degraded PE was lower in vivo (retrieved) than in vitro (shelf-aged) (Fig.…”

Section: Discussionmentioning

confidence: 54%

“…The aspect ratio of wear particles in our study was almost equal to that of in vivo wear particles (1.4-1.5) [9], although the ECD was smaller. However, in clinical results [18], the oxidative degradation of 100-Mrad PE was hardly noticeable, possibly as a result of the lower concentration of dissolved oxygen in vivo than that of gaseous oxygen in air (Fig. 5).…”

Section: Discussionmentioning

confidence: 93%

“…Oonishi, S. C. Kim, H. Oonishi H. Oonishi Memorial Joint Replacement Institute, Tominaga Hospital, Osaka, Japan M. Kyomoto, S. Masuda (&) Research Division, Japan Medical Materials Corporation, Uemura Nissei Bldg 9F 3-3-31 Miyahara, Yodogawa-ku, Osaka, Japan e-mail: masudas@jmmc.jp dose of 1000 kGy (100 Mrad), with the anticipation of improving wear and creep resistance [22]. A limited number of PE cups prepared by gamma irradiation at approximately 100 Mrad (henceforth called 100-Mrad PE) were first implanted in 1971, and they were subsequently marketed in 1973 [17,18]. These cups were withdrawn from the market in 1978 owing to the bankruptcy of the company providing the special irradiation treatment.…”

Section: Introductionmentioning

confidence: 99%

“…These cups were withdrawn from the market in 1978 owing to the bankruptcy of the company providing the special irradiation treatment. However, over the last 30 years, excellent clinical results have been observed with 100-Mrad PE [9,18,27]. Several studies suggest the linear wear rate in vivo of acetabular cups made from conventional PE (gamma-sterilized in air or inert gas) is as high as 0.1 to 0.2 mm per year [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Oxidation and Wear of 100-Mrad Cross-linked Polyethylene Shelf-aged for 30 Years

Kim

Oonishi

Kyomoto

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Some previous studies suggest that aging influences wear and oxidatively degraded nonsterilized ultra-high-molecular-weight polyethylene (UHMWPE) exhibits decreased wear resistance. We therefore asked whether shelf-aging storage conditions influenced degradation and wear resistance of gamma-irradiated UHMWPE. We examined oxidation and wear of 100-Mrad gamma-irradiated UHMWPE (100-Mrad polyethylene) cups shelf-aged for 30 years without (n = 2) or with (n = 2) packages. The oxidation index of the unpackaged 100-Mrad polyethylene surface (4) was higher than that of the packaged one (2.7). The packaged 100-Mrad polyethylene cup exhibited a high wear resistance with a steady wear rate of 0.5 mg/10 6 cycles. In contrast, the unpackaged 100-Mrad polyethylene exhibited an extremely high initial wear rate of 187.9 mg/10 6 cycles over the first 0.25 · 10 6 cycles with a subsequently reduced wear rate of 5 mg/10 6 cycles after 5 · 10 6 cycles. Packaging over long periods inhibits surface oxidation and maintains the wear resistance of gamma-irradiated UHMWPE cups.

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The effects of soft‐segment molecular weight and organic modifier on properties of organic‐modified MMT‐PU nanocomposites

Wang

Shieh

Nutt

2009

J of Applied Polymer Sci

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ABSTRACT:The effects of soft-segment molecular weight and organic modification of montmorillonite (MMT) on thermal and mechanical properties of segmented polyurethane (PU) elastomers were investigated. The PU/MMT nanocomposites were prepared by in situ polymerization, and the compositions included soft segments with number average molecular weights of 1000, 2000, and 2900, and organic-modified MMT (including MMT-30B and MMT-I30E). The nanocomposites produced were characterized using wide-angle X-ray diffraction (WAXD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and mechanical testing. The TEM and XRD results revealed that both MMT-30B and MMT-I30E were intercalated, and partially exfoliated by the PU. Mechanical tests showed that the PU1000 series in soft-segment molecular weight yielded superior tensile properties compared with the PU2000 and PU2900 series. Also, for a given molecular weight of soft segment in PU, the MMT-30B nanocomposites exhibited greater increases in Young's modulus, tensile strength, and elongation at break than the MMT-I30E counterpart, and the crystallinity of PU was enhanced by the clays.

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Study of retrieved acetabular sockets made from high-dose, cross-linked polyethylene

Cited by 32 publications

References 3 publications

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

Oxidation and Wear of 100-Mrad Cross-linked Polyethylene Shelf-aged for 30 Years

The effects of soft‐segment molecular weight and organic modifier on properties of organic‐modified MMT‐PU nanocomposites

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