Study of quantitative elastography with supersonic shear imaging in the diagnosis of breast tumours

Wang, Zhi Li; Li, Jun Lai; Li, Min; Huang, Yan; Wan, Wen; Tang, Jie

doi:10.1007/s11547-012-0903-x

Cited by 55 publications

(34 citation statements)

References 17 publications

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“…Further, low-grade malignant lesions and benign lesions with sclerosing components tend to yield to false-negative and false-positive results, respectively. This shows that malignant and benign breast lesions exhibit overlapping features, as reported in previous studies (16,18,22,26).…”

Section: Discussionsupporting

confidence: 86%

“…SWE differs from conventional elastography in that the former technique yields quantitative data and appears to be more reproducible and objective (16). In the present work, the most useful and reproducible measure was the mass/fat elasticity ratio, unlike what was found by Wang et al (P < 0.01 vs. P = 0.088) (18). Breast fat tissue shows minimal elastographic variability, and the elasticity values are very low, supporting the use of fat tissue stiffness as a comparator (16,19).…”

Section: Discussioncontrasting

confidence: 52%

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Use of shear wave elastography to differentiate benign and malignant breast lesions

Olgun

Korkmazer²,

Kılıç³

et al. 2014

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSE We aimed to determine the correlations between the elasticity values of solid breast masses and histopathological findings to define cutoff elasticity values differentiating malignant from benign lesions. MATERIALS and METHODSA total of 115 solid breast lesions of 109 consecutive patients were evaluated prospectively using shear wave elastography (SWE). Two orthogonal elastographic images of each lesion were obtained. Minimum, mean, and maximum elasticity values were calculated in regions of interest placed over the stiffest areas on the two images; we also calculated mass/fat elasticity ratios. Correlation of elastographic measurements with histopathological results were studied. RESULTS Eighty-three benign and thirty-two malignant lesions were histopathologically diagnosed. The minimum, mean, and maximum elasticity values, and the mass/fat elasticity ratios of malignant lesions, were significantly higher than those of benign lesions. The cutoff value was 45.7 kPa for mean elasticity (sensitivity, 96%; specificity, 95%), 54.3 kPa for maximum elasticity (sensitivity, 95%; specificity, 94%), 37.1 kPa for minimum elasticity (sensitivity, 96%; specificity, 95%), and 4.6 for the mass/fat elasticity ratio (sensitivity, 97%; specificity, 95%). CONCLUSION SWE yields additional valuable quantitative data to ultrasonographic examination on solid breast lesions. SWE may serve as a complementary tool for diagnosis of breast lesions. Long-term clinical studies are required to accurately select lesions requiring biopsy.

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 52%

Use of shear wave elastography to differentiate benign and malignant breast lesions

Olgun

Korkmazer²,

Kılıç³

et al. 2014

Diagn Interv Radiol

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show abstract

“…Other studies demonstrated that E max was the quantitative SWE feature of the optimal performance for breast cancer diagnosis733. In our study, E max showed remarkable performance, with an AUC of 0.943 in 2D SWE.…”

Section: Discussionsupporting

confidence: 64%

Application of 3D and 2D quantitative shear wave elastography (SWE) to differentiate between benign and malignant breast masses

Hui

Liu

Wang

et al. 2017

Sci Rep

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As breast cancer tissues are stiffer than normal tissues, shear wave elastography (SWE) can locally quantify tissue stiffness and provide histological information. Moreover, tissue stiffness can be observed on three-dimensional (3D) colour-coded elasticity maps. Our objective was to evaluate the diagnostic performances of quantitative features in differentiating breast masses by two-dimensional (2D) and 3D SWE. Two hundred ten consecutive women with 210 breast masses were examined with B-mode ultrasound (US) and SWE. Quantitative features of 3D and 2D SWE were assessed, including elastic modulus standard deviation (ESDE) measured on SWE mode images and ESDU measured on B-mode images, as well as maximum elasticity (Emax). Adding quantitative features to B-mode US improved the diagnostic performance (p < 0.05) and reduced false-positive biopsies (p < 0.0001). The area under the receiver operating characteristic curve (AUC) of 3D SWE was similar to that of 2D SWE for ESDE (p = 0.026) and ESDU (p = 0.159) but inferior to that of 2D SWE for Emax (p = 0.002). Compared with ESDU, ESDE showed a higher AUC on 2D (p = 0.0038) and 3D SWE (p = 0.0057). Our study indicates that quantitative features of 3D and 2D SWE can significantly improve the diagnostic performance of B-mode US, especially 3D SWE ESDE, which shows considerable clinical value.

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“…This observation is in good agreement with the results of a previously published study 24 . There are many studies focused on SWE diagnosis, but the Emax cutoff value, sensitivity and specificity were different 25, 26 . Berg et al .…”

Section: Discussionmentioning

confidence: 99%

Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer

Xue¹,

Li²,

Shi³

et al. 2017

Sci Rep

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This study investigated the relationship between quantitative parameters of shear wave elastography (SWE, maximum elasticity [Emax], minimum elasticity [Emin], mean elasticity [Emean]), collagen intensity and Kindlin-2 expression in benign and malignant breast nodules, and if Kindlin-2 expression is related with lymph node metastasis. A total of 102 breast nodules from 102 patients were included in our study who underwent ultrasound elastography before surgery or core needle biopsy. There was a significant difference between benign and malignant breast nodules in Emax, Emean, collagen intensity and Kindlin-2 expression, but it had no difference in Emin. Collagen intensity and Kindlin-2 expression both correlated positively with Emax, but not with Emean. Among 38 malignant breast nodules, the average Emax of the metastasis group was higher than that of the non-metastasis group, but it had no statistical significance. Compared with the non-metastasis group, Kindlin-2 expression was considerably higher in the metastasis group. However, there was no difference in collagen intensity between the metastasis group and the non-metastasis group. In conclusion, Kindlin-2 and collagen might contribute to breast nodule elasticity through molecular mechanisms. In breast cancer, overexpression of Kindlin-2 might be a risk factor for lymph node metastasis.

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Study of quantitative elastography with supersonic shear imaging in the diagnosis of breast tumours

Abstract: Shear-wave elastography gives quantitative elasticity information that could potentially help in breast-lesion characterisation, although it cannot replace conventional BI-RADS in the differentiation of breast lesions.

Cited by 55 publications

References 17 publications

Use of shear wave elastography to differentiate benign and malignant breast lesions

Use of shear wave elastography to differentiate benign and malignant breast lesions

Application of 3D and 2D quantitative shear wave elastography (SWE) to differentiate between benign and malignant breast masses

Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer

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