Study of puberty in type 1 diabetic boys

Attia, Abdalla M; Ghanayem, Naglaa M; Najjar, Mostafa M El; Taha, Doha A

doi:10.4103/1110-2098.141668

Cited by 2 publications

(2 citation statements)

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“…In our study, we found that short stature was related to lower weight, weight SDS, height SDS, BMI SDS, waist circumference, hip circumference, and Hip circumference SDS compared to diabetic patients with normal stature. Similarly, several previous studies revealed that anthropometrical measurements (weight, height, and BMI) were significantly low among diabetic patients [ 19 , 28 – 30 ]. On the contrary, Clarson et al .…”

Section: Discussionsupporting

confidence: 61%

“…These results are in agreement with an earlier study which reported that full sexual maturation in T1D boys (stage 5) is retarded and occurs at a mean age of 17.2 years [ 46 ]. Also, Attia and colleagues found that T1D causes marked retardation of puberty, where nearly 25% of the diabetic boys were not sexually mature [ 28 ]. Meanwhile, Zurita-Cruz et al .…”

Section: Discussionmentioning

confidence: 99%

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Insulin-like growth factor 1 and sex hormones for assessment of anthropometric and pubertal growth of Egyptian children and adolescents with type 1 diabetes mellitus (single center study)

Thabet,

Sherif,

ElAal

et al. 2024

BMC Endocr Disord

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Background This study aimed to assess the anthropometric measures and pubertal growth of children and adolescents with Type 1 diabetes mellitus (T1DM) and to detect risk determinants affecting these measures and their link to glycemic control. Patients and methods Two hundred children and adolescents were assessed using anthropometric measurements. Those with short stature were further evaluated using insulin-like growth factor 1 (IGF-1), bone age, and thyroid profile, while those with delayed puberty were evaluated using sex hormones and pituitary gonadotropins assay. Results We found that 12.5% of our patients were short (height SDS < -2) and IGF-1 was less than -2 SD in 72% of them. Patients with short stature had earlier age of onset of diabetes, longer duration of diabetes, higher HbA1C and urinary albumin/creatinine ratio compared to those with normal stature (p < 0.05). Additionally, patients with delayed puberty had higher HbA1c and dyslipidemia compared to those with normal puberty (p < 0.05). The regression analysis revealed that factors associated with short stature were; age at diagnosis, HbA1C > 8.2, and albumin/creatinine ratio > 8 (p < 0.05). Conclusion Children with uncontrolled T1DM are at risk of short stature and delayed puberty. Diabetes duration and control seem to be independent risk factors for short stature.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Insulin-like growth factor 1 and sex hormones for assessment of anthropometric and pubertal growth of Egyptian children and adolescents with type 1 diabetes mellitus (single center study)

Thabet,

Sherif,

ElAal

et al. 2024

BMC Endocr Disord

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Methylation pattern variation between goats and rats during the onset of puberty

Yang

Liu

et al. 2018

Reprod Domestic Animals

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Puberty is initiated by increased pulsatile gonadotropin-releasing hormone (GnRH) release from the hypothalamus. Epigenetic repression is thought to play a crucial role in the initiation of puberty, although the existence of analogous changes in methylation patterns across species is unclear. We analysed mRNA expression of DNA methyltransferases (DNMTs) and methyl-binding proteins (MBPs) in goats and rats by quantitative real-time PCR (qRT-PCR). DNA methylation profiles of hypothalamic were determined at the pre-pubertal and pubertal stages by bisulphite sequencing. In this study, expression of DNMTs and MBPs mRNA showed different patterns in goats and rats. Global methylation variation was low in goats and rats, and the profile remained stable during puberty. Gene ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis revealed the involvement of 62 pathways in puberty in goats and rats including reproduction, type I diabetes mellitus and GnRH signalling pathways and found that Edn3, PTPRN2 and GRID1 showed different methylation patterns during puberty in goats and rats and similar variation patterns for Edn3 and PTPRN2 were showed. These indicated that Edn3 and PTPRN2 would play a role in the timing of puberty. This study provides evidence of the epigenetic control of puberty.

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Study of puberty in type 1 diabetic boys

Cited by 2 publications

References 0 publications

Insulin-like growth factor 1 and sex hormones for assessment of anthropometric and pubertal growth of Egyptian children and adolescents with type 1 diabetes mellitus (single center study)

Insulin-like growth factor 1 and sex hormones for assessment of anthropometric and pubertal growth of Egyptian children and adolescents with type 1 diabetes mellitus (single center study)

Methylation pattern variation between goats and rats during the onset of puberty

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