Study of potential binding of biologically important sugars with a dinuclear cobalt(II) complex

Synthesis, Characterization, and Spectroscopic Investigation of New Iron(III) and Copper(II) Complexes of a Carboxylate Rich Ligand and Their Interaction with Carbohydrates in Aqueous Solution

“…This was expected, partially due to the higher charge and greater Lewis acidity of the Fe(III) center when compared to the Cu(II) and Co(II). While previously reported p K app values for [Cu 2 (bpdpo)] 2+ and [Cu 2 (hpnbpda)(μ-OAc)] with d -xylose are 3.55 ± 0.03 , and 2.51 ± 0.09, respectively, Co(II) complexes with similar ligands have values of 2.93 ± 0.11 and 2.55 ± 0.09 . Hence, the 2.52 ± 0.32 value obtained for K 4 [ 1 ]·25H 2 O·(CH 3 ) 2 CO is comparable to those reported for Cu(II) and Co(II).…”

“…Although carbohydrates have multiple hydroxyl groups, which could all theoretically bind to a suitable acceptor, it has been demonstrated that binding with these types of complexes typically occur through the hydroxyl groups attached to the anomeric carbon C 1 and C 2 . ,,, The observed stronger d -mannose binding than the d -glucose or d -xylose, could be due to the difference in the configuration of the hydroxyl group at the C 2 positions. The strong binding interaction exhibited by d -mannose compared to d -xylose could have stemmed partly from structural differences between the substrates, specifically the configuration of the hydroxyl group at the C 2 position. ,,, Specific binding modes of d -glucose have been established and previously reported in literature by using 13 C NMR spectroscopy technique for a dinuclear Zn(II) complex which provided strong evidence that coordination to the metal centers occurs primarily through the hydroxyl groups on C 1 and in equilibrium with the hydroxyl groups at C 2 and/or C 3 . Although no single crystal X-ray structure of any of the complexes is reported, similar mode of coordination with dinuclear Cu(II) ,, and Co(II) complexes have been proposed in the literature.…”

“…To understand the carbohydrate metal ion interactions in biological processes, several synthetic complexes have been prepared and reported in the literature as structural and functional models. − It has also been elucidated that carboxylate-bridged divalent dinuclear complexes with Mg 2+ , Mn 2+ , Co 2+ , − Ni 2+ , and Zn 2+ ,, are involved in many enzymatic nonredox active processes. However, unlike the case with various other metalloenzymes, the study of metalloenzymes involved with carbohydrates using synthetic models is largely unexplored.…”

Cu(II), Mn(II) and Zn(II) Complexes of Anthracene‐Affixed Carboxylate‐Rich Tridentate Ligand: Synthesis, Structure, Spectroscopic Investigation and Their DNA Binding Profile

“…The most important coordination modes of the carboxylate groups are monodentate, syn‐syn bidentate, syn‐anti bidentate and anti‐anti bidentate [46,47] . In our laboratory, we have found that several di‐ and multinuclear Cu(II), Ni(II), Zn(II), Co(II) and Mn(II) complexes of carboxylate‐based multidentate ligands have exhibited the excellent binding interactions towards the biologically significant substrates such as DNA, BSA and different monosaccharides, in solution [48–54] . Recently, we have reported the synthesis, characterization, X‐ray crystal structure and phosphatase‐like activity of tetranuclear complexes of iron(III), zinc(II) and nickel(II) by utilizing carboxylate‐based multidentate ligands with appealing coordination chemistry [55,56] .…”

“…[46,47] In our laboratory, we have found that several diand multinuclear Cu(II), Ni(II), Zn(II), Co(II) and Mn(II) complexes of carboxylate-based multidentate ligands have exhibited the excellent binding interactions towards the biologically significant substrates such as DNA, BSA and different monosaccharides, in solution. [48][49][50][51][52][53][54] Recently, we have reported the synthesis, characterization, X-ray crystal structure and phosphatase-like activity of tetranuclear complexes of iron(III), zinc(II) and nickel(II) by utilizing carboxylate-based multidentate ligands with appealing coordination chemistry. [55,56] In this article, we report anthracene-appended carboxylate containing tridentate ligand, H 2 acpa which upon reaction with Cu((II), Mn(II) and Zn(II) salts, yields new mononuclear complexes, [Cu-…”