Study of Possible Complex Formation Between Macromolecules and Certain Pharmaceuticals

Influence of Polyethylene Glycols on the Hemolytic Activity of Phenolic Preservatives

“…The interactions of phenols and macromolecules of the polyoxyethylene type have generally been attributed to hydrogen bond formation between the hydrogen of the phenolic hydroxyl group and the oxygen of the ether linkage (13)(14)(15). The inactivation of phenols in micelles has also advanced as a possible mechanism of the interaction (16).…”

“…2, the hemolytic activity of 5.0 X lo-* M phenol decreased with increased concentrations of polyethylene glycols. The PEG concentrations were calculated on a repeating unit basis, this is, gram equivalents of ethylene oxide linkage (O-CHz-CH,) per liter of solution (13). Polyethylene glycols 1000, 1540,4000, and 6000 were similarly effective in interacting with phenol, thus preventing hemolysis.…”

“…The interactions of preservatives with other substances have been studied by such physical chemical methods as equilibrium dialysis (7-10, 14,15) and phase analysis (13,14), and biologically by a manometric method (23) utilizing baker's yeast and a turbidimetric method (22, 24) in which the growth of microorganisms reflects preservative inactivity. An earlier report (25) indicated microorganism killing and erythrocyte hemolysis by certain antibacterial preservatives to be quantitatively comparable.…”

Interaction of Sucrose and Propoxylated Sucrose Esters with Some Pharmaceuticals

“…(34)(35)(36)(37) to account for the experimental data generally obtained. I t was believed that hydrogen bonding was the major driving force of these interactions in the early work conducted with water soluble polymers (34).…”

Further aspects of the physical chemistry of some non-ionic detergents

“…Lack (1954), andGuttman (1956), have reported complex formation of phenolic substances with polyoxyethylene groups, and it has been observed that many phenolic substances were readily dissolved in concentrated solutions of polyoxyethylene glycols (Nakagawa, 1954 ;.…”