Study of porous interconnections of bioceramic on cellular rehabitation in vitro and in vivo

Lu, Junlin; Flautre, B.; Anselme, Karine; Gallur, A.; Descamps, M.; Thierry, B.; Hardouin, Pierre

doi:10.1016/b978-008042692-1/50138-2

Cited by 151 publications

(217 citation statements)

References 4 publications

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“…But the size of the pores and interconnections has the effect on the bone ingrowth. HA with 500 lm pores had stronger osteogenesis than that with 200 lm [12] and the interconnection size over 50 lm could assure mineralised bone formation [14]. A 130 lm mean interconnection size and a 175-260 lm pore diameter size led to the best osteoconduction result in the ceramic centre [7].…”

Section: Discussionmentioning

confidence: 99%

Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes

et al. 2006

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“…Na maioria dos animais essa invasão foi periférica, sugerindo uma possível incorporação do polímero ao tecido. Segundo Lu et al (1999), 20μm de diâmetro é o tamanho mínimo para um poro facilitar a penetração celular, porém poros maiores que 50μm diâmetro são necessários para promover a formação de novo osso. Sendo assim, no presente estudo somente foram aferidos os poros acima de 400μm 2 de área.…”

Section: Discussionunclassified

Resposta tecidual a implantes de discos de poliuretana de mamona nas formas pré-moldada ou biomassa moldada

et al. 2010

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RESUMO.-O trabalho teve por objetivo avaliar a resposta tecidual à implantação de discos de poliuretana derivada do óleo de mamona confeccionados de duas formas distintas, na forma pré-moldada fornecida pela indústria e em biomassa moldada no momento da aplicação, de forma a observar se haveria algum tipo de reação local tardia associada à possível continuidade do processo de endurecimento final do biomaterial. Foram utilizados 20 ratos, linhagem Wistar, fêmeas, com peso de 300-350g, nos quais foi inserido o disco pré-moldado no tecido subcutâneo do flanco direito e o de biomassa moldada no flanco esquerdo. Ambos os discos tinham 0,8cm de diâmetro por 0,5cm de espessura. Para o procedimento histológico, cinco ratos foram submetidos à eutanásia aos 3, 7, 15 e 30 dias de pós-cirúrgico. Os implantes e tecidos circundantes foram colhidos, processados e corados pela técnica de hematoxilina-eosina. Foi observada inicialmente uma reação inflamatória moderada, composta especialmente por células polimorfonucleares e macrófagos. Os linfócitos variaram de ausentes a discretos. A reação inflamatória diminui de intensidade à medida que se intensificou a formação de tecido conjuntivo fibroso ao redor dos implantes, porém sem modificação dos núme-ros de macrófagos. Sendo assim, conclui-se que ambos os

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“…The pore size favorable to bone formation and cell regeneration was over 300 m [19]. As well as the interconnected pores favors to cell ingrowth inside the pore [18]. But, there are no report on suitable porosity for these applications.…”

Section: Effect Of Pmma and H 2 O 2 On Mechanical Strengthmentioning

confidence: 99%

“…However, pore sizes over 300 m was favorable to enhanced new bone formation and cell regeneration [18,19]. Therefore, the sample prepared by combination technique using both PMMA and H 2 O 2 can provide the pores attaining these requirements.…”

Section: Effect Of Pmma and H 2 O 2 On Porositymentioning

confidence: 99%

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Fabrication of Porous Hydroxyapatite through Combination Of Sacrificial Template and Direct Foaming Techniques

Woottichaiwat¹,

Puajindanetr²,

Best³

2011

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Abstract. The porous hydroxyapatite (HA) bioceramics were prepared through combination of sacrificial template and direct foaming techniques using PMMA granules (varied from 5 to 50wt% in content) as a template and H 2 O 2 solution (varied from 5 to 30wt% in concentration) as a foaming agent, respectively. The effects of PMMA content and H 2 O 2 concentration on final porosity, microstructure and mechanical strengths were studied. The porous samples using PMMA provided the porosity ranging from 52% to 75%, the samples using H 2 O 2 had the porosity ranging from 82% to 85%, and the sample using both pore formers provided the porosity ranging between 84% and 90%. The higher content of PMMA and concentration of H 2 O 2 led the porosity increased, leading to a decrease in the compressive and flexural strengths. Furthermore, this combination technique allowed interconnected pores having two levels of pore size, which came from PMMA and H 2 O 2 . The PMMA formed the small pores with the diameter ranging between 100 and 300 m, while H 2 O 2 provided the larger pores with the diameter ranging from 100 to 1,000 m depending on concentration.

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Study of porous interconnections of bioceramic on cellular rehabitation in vitro and in vivo

Cited by 151 publications

References 4 publications

Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes

Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes

Resposta tecidual a implantes de discos de poliuretana de mamona nas formas pré-moldada ou biomassa moldada

Fabrication of Porous Hydroxyapatite through Combination Of Sacrificial Template and Direct Foaming Techniques

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