Study of platelet indices in hyperlipidemia

Abstract

Introduction: Atherosclerosis is a chronic inflammatory condition n resulting from hyperlipidemia and involves platelet mediated recruitment of white blood cells to arteries. The platelet activation is measured indirectly through several platelet indices routinely available without any additional cost in newer fully automated haematology analysers. These indices include platelet count, mean platelet volume(MPV), platelet distribution width(PDW), plateletcrit(PCT), mean platelet(component) concentration (MPC), mean platelet dry mass (MPM), platelet large cell count and platelet large cell ratio (PLCR).. The present study was undertaken in the pathology department of our diagnostic centre to find an association between platelet indices reported by Advia 2120(Siemens) fully automated haematology analyser and hyperlipidemia. Materials and Methods: This was a prospective study carried out in our diagnostic centre from April to July 2018. 100 patients with hyperlipidemia without any associated diseases and 100 controls with normal lipid profile were included in the study. Statistical analysis was done using Pearson's correlation test and data was expressed as mean ±SD for each parameter. A p value of < 0.05 was considered to be significant. Results: Maximum number of patients were in 41-60 years of age (65%). The male to female ratio was 1.7: 1 with 63% males and 37% females. The mean cholesterol ,mean triglyceride and mean HDL cholesterol level in study group was 218.6±36.3, 244.3±154,38.7±9.6 respectively and 158±26.8 ,94.1±34.8,and 42.1±9.3 in control group respectively. Mean LDL cholesterol was 131.1±39.4 in study group and 97.1±25.2 in control group. There was a significant difference in platelet counts in both groups with a p value of 0.01. PCT and MPC also showed a p value of 0.004. The mean platelet mass (MPM) was 2.17±0.2 in study group as compared to 2.13±021 in control group. Large platelet count was 7.09±4.9 in study group while it was 5.95±3.81 in control group which was also significantly different. Conclusion:Our study indicates that PCT, MPM large platelets and platelet count are significantly higher in hyperlipidemia patients.These indices are available without any additional cost to clinicians, pathologists and patients and can be used to assess the risk associated with hyperlipidemia.

Hyperlipidemia and Platelet Parameters: Two Sides of the Same Coin

“…Hence, we have conducted a present case-control study with both age and sex-matched controls to keep away such bias in our results. In our study, we observed a male-to-female ratio of 1.5:1 among cases which correlates with the study done by Khemka and Kulkarni and Hawaldar and Sodani [ 14 - 15 ].…”

Study of Relationship Between Platelet Parameters and Hyperlipidemia

“…and discordance to Hawaldar R. et al and Khemka R et al Female preponderance in the present study could be due to most of the females visiting the hospital in their 5 th decade of life, increased sedentary life, smoking, and various hormonal imbalances. The maximum number of patient in the present study were in the 41-60 years age group which correlate with the study of Hawaldar R. et al and Janani K et al 13,14 Age was not found to be statistically significant in both the groups. However, hyperlipidemia in younger children may be due to familial hypercholesterolemia and the popularity of fast food consumption among the young age groups.…”

Platelet‐associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity

“…Finally, in relation to DL, in the cohort studied by Singh et al., there was a positive association between DL and MPV, but nonsignificant results were found regarding PCT 45 . In contrast, other studies with considerably larger cohorts reported a positive association between LDL/VLDL cholesterol and PCT and PLA, but no association with MPV was reported 46,47 . Given our paradoxical findings, we should note that 59.5% of dyslipidaemic patients in our cohort were treated with statins and, therefore, did not present a significant increase in LDL cholesterol levels.…”

“…45 In contrast, other studies with considerably larger cohorts reported a positive association between LDL/ VLDL cholesterol and PCT and PLA, but no association with MPV was reported. 46,47 Given our paradoxical findings, we should note that 59.5% of dyslipidaemic patients in our cohort were treated with statins and, therefore, did not present a significant increase in LDL cholesterol levels. In addition, it has been stated that the use of statins can affect MPV.…”