Study of plasma fibrinogen level in type 2 diabetes mellitus and its association with microalbuminuria and glycemic control

Saini, Pankaj; Saluja, Manoj; Meena, Shivraj; Meena, Shyam Bihari

doi:10.1016/j.cmrp.2016.05.002

Cited by 4 publications

(7 citation statements)

References 20 publications

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“…P values for TC, LDL, HDL and TG were 0.410, 0.003, 0.303, and 0.108 respectively. The significant association of serum fibrinogen levels in our study with TC, LDL cholesterol, and TG with inverse association with HDL cholesterol were consistent with study conducted by Saini et al and Ernst et al 19,9 Bruno et al, reported that in multiple regression analysis HbA1c was associated with fibrinogen level. 20 Our findings are consistent with this study.…”

Section: Resultssupporting

confidence: 93%

“…Similar observation was made in some other studies. 10,18,19 In the present study the serum fibrinogen level did not show significant correlation with duration of DM (P-value >0.05). This was in accordance with the studies conducted by Jain et al and Saini et al 10,19 In the present study serum fibrinogen level showed significant and positive correlation with BMI.…”

Section: Resultscontrasting

confidence: 62%

“…These findings are similar to other studies. [16][17][18][19][20]23 In the present study correlation between serum fibrinogen was 0.11, 0.20, -0.11, 0.11, 0.59, and 0.45 with TC, LDL cholesterol, HDL cholesterol, TG, HbA1c, and BMI respectively. Jain et al, reported fibrinogen levels were associated with BMI (r = 0.90), TG (r = 0.94), TC (r = 0.99), and HbA1c (r = 0.99) in DM patients in a significant manner.…”

Section: Resultssupporting

confidence: 51%

“…10,16,18,19 In the present research distribution of mean serum fibrinogen did not differ significantly between hypertensive and non-hypertensive cases studied (P-value>0.05). Similar findings were reported by Jain et al, Bembde and Saini et al 10,18,19 reported that fibrinogen levels were associated with hypertension (p<0.01). The mean ± standard deviation of HbA1c of entire study group was 8.3 %±1.4%.…”

Section: Resultscontrasting

confidence: 44%

“…The studies conducted by Jain et al, Bembde, Saini et al and Bruno et al reported that serum fibrinogen had a significant correlation with age. 10,[18][19][20] They reported that mean serum fibrinogen levels increased with increase in age. In the present study mean serum fibrinogen level in males (371.1±139.5) was higher than in females (354.5±125.2) but this difference was not statistically significant.…”

Section: Resultsmentioning

confidence: 99%

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Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Topiwala¹,

Bahulikar²,

Beke³

et al. 2019

Int J Adv Med

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Background: Poor glycemic control has been reported to be associated with increased vascular complications in diabetes mellitus (DM) patients. High fibrinogen level has been described as an independent risk factor for cardiovascular diseases. High fibrinogen has been suggested to be involved in the excess rate of cardiovascular diseases in patients with type 2 DM. The present study was undertaken to find correlation between glycemic control and plasma fibrinogen level in patients with type 2 DM.Methods: Three hundred ten patients aged ≥30 years of either sex were included in this cross sectional study. Estimation of glycated haemoglobin (HbA1c), serum fibrinogen, serum total cholesterol (TC), serum triglycerides (TG), serum high density lipoprotein (HDL) cholesterol, and serum low density lipoprotein (LDL) cholesterol was done. Categorical and continuous variables were tested using Chi-Square test/Fisher’s exact test and unpaired ‘t’ test respectively. Pearson’s correlation was used to study correlation between serum fibrinogen levels and HbA1c, Body mass index (BMI), TC, LDL cholesterol, HDL cholesterol, and TG.Results: Mean serum fibrinogen levels were significantly higher in DM patients whose HbA1c, LDL cholesterol and TG levels were higher. Correlation between serum fibrinogen was 0.59, and 0.45 with HbA1c, and BMI respectively. Multivariate step-wise regression analysis showed higher HbA1c and higher BMI were the independent and significant predictors of higher serum fibrinogen levels. HbA1c was the stronger predictor of serum fibrinogen than BMI.Conclusions: Fibrinogen levels were independently associated with HbA1c value in patients with type 2 DM.

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Section: Resultssupporting

confidence: 93%

Section: Resultscontrasting

confidence: 62%

Section: Resultssupporting

confidence: 51%

Section: Resultscontrasting

confidence: 44%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Topiwala¹,

Bahulikar²,

Beke³

et al. 2019

Int J Adv Med

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Diabetes affects endothelial cell function and alters fibrin clot formation in a microvascular flow model: A pilot study

Jenny

Melmer

Laimer

et al. 2020

Diabetes and Vascular Disease Research

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Diabetes is a proinflammatory and prothrombotic condition that increases the risk of vascular complications. The aim of this study was to develop a diabetic microvascular flow model that allows to study the complex interactions between endothelial cells, blood cells and plasma proteins and their effects on clot formation. Primary human cardiac microvascular endothelial cells from donors without diabetes or donors with diabetes (type 1 or type 2) were grown in a microfluidic chip, perfused with non-diabetic or diabetic whole blood, and clot formation was assessed by measuring fibrin deposition in real time by confocal microscopy. Clot formation in non-diabetic whole blood was significantly increased in the presence of endothelial cells from donors with type 2 diabetes compared with cells from donors without diabetes. There was no significant difference in clot formation between non-diabetic and diabetic whole blood. We present for the first time a diabetic microvascular flow model as a new tool to study clot formation as a result of the complex interactions between endothelial cells, blood cells and plasma proteins in a diabetes setting. We show that endothelial cells affect clot formation in whole blood, attributing an important role to the endothelium in the development of atherothrombotic complications.

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Study of Plasma Fibrinogen Levels in Acute Stroke

Jain¹,

Tilgam²

2022

IJAR

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Background: Stroke is a disease of paramount public health significance. The role of plasma fibrinogen in determining incidence and severity of stroke has been postulated time and again. Present study was undertaken to determine the correlation between mean plasma fibrinogen level and infarct volume on CT scan in patients with acute stroke. Methods: Source of data: Plasma fibrinogen of 50 consecutive patients presenting with acute stroke admitted in Netaji Shubhas Chandra Bose Medical College & Hospital, Jabalpur from March 2019 to August 2020 and compared with 50 controls not suffering from stroke with matched age, sex and risk factors (controls) such as heart disease, hypertension, Diabetes and obesity, smoking and use of alcohol. Method of collection of data. The study will be carried out on 50 consecutive patients admitted to N S C B Medical College & Hospital, Jabalpur with acute stroke within 24 hours of the onset of symptoms. Detailed history will be taken to find out the risk factors such as hypertension, diabetes, smoking and alcohol consumption. Hypertension will be diagnosed by JNC VII criteria. Diabetes will be diagnosed by American Diabetes Association criteria. Smoking will be recorded in terms of number of cigarette pack years smoked. Thorough general and systemic examination will be carried out. In addition to routine investigations as per standard protocol in the evaluation of stroke patient, fasting plasma fibrinogen level is estimated and compared to age sex and risk factors matched controls. Result: In this study Fibrinogen levels among patients of stroke were estimated. Data on demography (age, sex, habit of smoking, tobacco and alcohol) and clinical parameters (BMI, heart disease, Hypertension and Diabetes) was also collected. All 50 patients of stroke cases was compared with 50 control subjects, matched for age, sex, obesity, clinical parameters like heart disease, hypertension and diabetes and also for habits of smoking, tobacco use and alcohol.

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Study of plasma fibrinogen level in type 2 diabetes mellitus and its association with microalbuminuria and glycemic control

Cited by 4 publications

References 20 publications

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Association between glycemic control and serum fibrinogen levels in type 2 diabetes mellitus patients

Diabetes affects endothelial cell function and alters fibrin clot formation in a microvascular flow model: A pilot study

Study of Plasma Fibrinogen Levels in Acute Stroke

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