Study of Photoinduced Antitumor Activity of Phthalocyanin-Based Nanostructures as Pro-Photosensitizers in Photodynamic Therapy of Malignant Tumors In Vivo

Abstract

Nanoparticles of aluminum and zinc phthalocyanin and metal-free phthalocyanin (AlPc, ZnPc, and H2Pc), whose molecular forms are photosensitizers, can serve as effective "prophotosensitizers" in photodynamic therapy for malignant tumors. Transition (stimulation) of photo-inert nanoparticles into a photoactive photosensitizer is realized locally in the tumor node by its exposure to potent laser pulses. Systemic injection of AlPc, ZnPc, and H2Pc nanoparticles has not led to accumulation of their photoactive form in the skin, which can lead to the development of skin phototoxicity. Effective protocols of photodynamic therapy with ZnPc nanoparticles are determined. The use of these protocols in mice with S-37 sarcoma led to 92-70% tumor growth inhibition, 48% improvement of survival, and cure in 84% cases.

A remote marking device and newly developed permanent dyes for Wildlife research

“…Cobalt Phthalocyanine and Iron (II) Phthalocyanine are in a class of drugs that is pharmacologically inactive, but when exposed to ultraviolet radiation or sunlight is converted to its active metabolite that affects diseased tissue (Staicu et al ). These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms as well as Alzheimer's disease (Pankratov et al , Tabassum et al ). Cobalt Phthalocyanine is also an antitumor delivery system by itself when combined with citric acid (Medvedev and Leshchenko ) .…”

Nanosense: Nonsurgical treatment of superficial cancer by (PLAN)

“…The PLAN method was developed jointly by scientists from FSUE "GNC "NIOPIK" FSBI "MNIOI named after P.A. Herzen" (Kogan et al 2004(Kogan et al , 2006(Kogan et al , 2008(Kogan et al , 2010(Kogan et al , 2011a(Kogan et al , 2011bAndreeva et al 2012;Pankratov et al 2014). It is protected by three patents (RF Patent 2008;RF Patent 2010;Patent RU 2017).…”

“…A Russian scientist (Kogan et al 2004;Pankratov et al 2014) has discovered that photoactive aluminum phthalocyanine nanoparticles, zinc phthalocyanine, and metal-free phthalocyanine, under the influence of pulsed laser radiation, can form molecular forms that act as photosensitizers. Phthalocyanines are organic dyes that are inert, non-toxic, and insoluble in organic solvents and water.…”

The p-Metal Porphyrins: from Specificity of Properties to Application in Medicine, Catalysis, and Optoelectronics

“…Most notably, they combine interesting spectroscopic and chemical properties as the luminescent properties and particular oxophilicity with the 14 group porphyrin complexes [26] or the coordination with two and three porphyrin N atoms only with the boron and tellurium complexes, respectively. [47] Many works [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] can be cited, in which using the maingroup porphyrin/phthalocyanine complexes as aluminumsubstituted heme, anticancer/phototeranoctic agents, prophotosensitizers/singlet oxygen sensitizers, template agents in the tetrapyrrole macrocycle synthesis, electron acceptor materials for organic electronics, and chemosensors were studied. Generalizations in the area under consideration have been undertaken in three reviews [27,48,66] where the earlier ones was mentioned and, in part, in two more reviews.…”