Study of pathway cross-talk interactions with NF-κB leading to its activation via ubiquitination or phosphorylation: A brief review

Ghosh, Sayantan; Dass, J. Febin Prabhu

doi:10.1016/j.gene.2016.03.008

Cited by 105 publications

(87 citation statements)

References 34 publications

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“…NF-κB then translocates to the nucleus and regulates the expression of pro-inflammatory genes, including MCP-1 [39]. Many studies show that inhibition of NF-κB reduces the release of inflammatory cytokines and inducible nitric oxide synthase (iNOS), and protects mice against lethal endotoxemia [12].…”

Section: Discussionmentioning

confidence: 99%

Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice

Zhai

et al. 2017

Cytokine

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Myocardial inflammatory responses to endotoxemia are enhanced in old mice, which results in worse cardiac dysfunction. Anti-inflammatory cytokine interleukin (IL)-37 has a broad effect on innate immunoresponses. We hypothesized that IL-37 suppresses myocardial inflammatory responses to protect cardiac function during endotoxemia in old mice. Old (20–24 month) wild-type (WT), and IL-37 transgenic (IL-37tg) mice were treated with lipopolysaccharide (LPS, 0.5 mg/kg, iv) or normal saline (0.1 ml/mouse, iv). Six hours later, left ventricle (LV) function was assessed using a pressure-volume microcatheter. Levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in plasma and myocardial tissue, as well as mononuclear cell density in the myocardium, were examined. Cardiac microvascular endothelial cells isolated from WT and IL-37tg mice were treated with LPS (0.2 μg/ml) for 0.5–24 hours. Nuclear factor-kappa B (NF-κB) p65 phosphorylation was examined by immunoblotting, and MCP-1 levels in cell culture supernatant was determined using enzyme-linked immunosorbent assay. LV dysfunction in old WT endotoxemic mice was accompanied by up-regulated MCP-1, myocardial accumulation of mononuclear cells and production of TNF-α, IL-1β and IL-6. Expression of IL-37 suppressed myocardial inflammatory responses to endotoxemia in old mice, resulting in improved LV function. Treatment of old WT endotoxemic mice with recombinant IL-37 also improved LV function. In vitro experiments revealed that cardiac microvascular endothelial cells from IL-37tg mice had attenuated NF-κB activation and MCP-1 production following LPS stimulation. In conclusion, IL-37 is potent to suppress myocardial inflammation and protects against cardiac dysfunction during endotoxemia in old mice.

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Section: Discussionmentioning

confidence: 99%

Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice

Zhai

et al. 2017

Cytokine

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“…Other signalling pathways also control cell functions and are, of course, important. Furthermore, in the complex nature of multiple signalling pathways there is also considerable crosstalk between these pathways [42]. There are also some reports that vitamin K has regulatory functions on signalling pathways, other than NF-κB, such as the mitogen-activated protein (MAP) kinases, but in this discussion, we focus on vitamin K and NF-κB.…”

Section: Nf-κb and Vitamin Kmentioning

confidence: 98%

Anti-Inflammatory Actions of Vitamin K

Hodges¹,

Pitsillides²,

Ytrebø³

et al. 2017

Vitamin K2 - Vital for Health and Wellbeing

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Naphthoquinone compounds have received attention for their ability to regulate diseases from bacterial and parasite infections through to chronic human diseases. Inflammation is widely considered to be at the root of many chronic diseases. The reports of anti-inflammatory activity of naphthoquinones, including vitamin K1 (phylloquinone) and vitamin K2s (menaquinones), are of interest due to their very low toxicity. Most of the evidence for the anti-inflammatory mechanisms of vitamin K suggests a role in the inhibition of the cell signalling complex nuclear factor kappa-B (NF-κB).

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“…In cancer cells, some of those pathways are dysregulated. NF-κB has been associated with the regulation of several processes such as inflammation, cell growth, and apoptosis (Ghosh and Dass, 2016). This nuclear transcription factor also controls several other biological pathways such as the MAPK or PI3K/Akt pathways.…”

Section: Scientific Evidence and Mechanisms Of Actionmentioning

confidence: 99%

North African Medicinal Plants Traditionally Used in Cancer Therapy

et al. 2017

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Background: Cancer is a major cause of mortality worldwide with increasing numbers by the years. In North Africa, the number of cancer patients is alarming. Also shocking is that a huge number of cancer patients only have access to traditional medicines due to several factors, e.g., economic difficulties. In fact, medicinal plants are widely used for the treatment of several pathologies, including cancer. Truthfully, herbalists and botanists in North African countries prescribe several plants for cancer treatment. Despite the popularity and the potential of medicinal plants for the treatment of cancer, scientific evidence on their anticancer effects are still scarce for most of the described plants.Objective: Bearing in mind the lack of comprehensive and systematic studies, the aim of this review is to give an overview of studies, namely ethnobotanical surveys and experimental evidence of anticancer effects regarding medicinal plants used in North Africa for cancer therapy.Method: The research was conducted on several popular search engines including PubMed, Science Direct, Scopus and Web of Science. The research focused primarily on English written papers published between the years 2000 and 2016.Results: This review on plants traditionally used by herbalists in North Africa highlights that Morocco and Algeria are the countries with most surveys on the use of medicinal plants in folk medicine. Among the plethora of plants used, Nigella sativa and Trigonella foenum-graecum are the most referred ones by herbalists for the treatment of cancer. Moreover, a plethora of scientific evidence qualifies them as candidates for further drug development. Furthermore, we report on the underlying cellular and molecular mechanisms.Conclusion: Overall, this review highlights the therapeutic potential of some medicinal plants as anticancer agents. The North African flora offers a rich source of medicinal plants for a wide array of diseases, including cancer. The elucidation of their modes of action represents an indispensable condition for the rational development of new drugs for cancer treatment. Furthermore, testing the anticancer activity in vivo and in clinical trials are warranted to explore the full therapeutic potential of North African plants for cancer therapy.

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Study of pathway cross-talk interactions with NF-κB leading to its activation via ubiquitination or phosphorylation: A brief review

Cited by 105 publications

References 34 publications

Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice

Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice

Anti-Inflammatory Actions of Vitamin K

North African Medicinal Plants Traditionally Used in Cancer Therapy

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