Study of ocular manifestations in children of thalassemia

Gosai, Dhara; Mehariya, K M; Gosai, Jigarkumar B.

doi:10.5455/2320-6012.ijrms20140561

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Based on our results, none of our patients had reduced best-corrected Snellen VA lower than 20/40. In contrast, Taher et al [ 6 ] and Gosai et al [ 9 ] reported reduced vision with a frequency of 19.4 and 26% in younger patients compared with ours. Considering VA > 0.1 logMar in our study three patients (3.8%) had reduced vision compared to 23.2% of children with thalassemia major, which was reported by Aksoy et al [ 7 ].…”

Section: Discussioncontrasting

confidence: 89%

“…Ocular complications may occur via several mechanisms, such as microvasculature disease, chronic anemia, iron overload and iron chelator toxicity, as well as abnormal orbit growth due to unusual craniofacial growth [ 4 , 5 ]. Common ophthalmologic findings in patients with TDT comprises of changes in visual acuity (VA), cataract and lens opacity, obliteration of iris pattern, shortened axial length, thickened lens, steepened corneal curvature, astigmatism, disturbances in tear function, and retinal abnormalities, such as retinal pigment epithelium (RPE) degeneration, optic neuropathy, retinal vessel tortuosity and vitreoretinal hemorrhage [ 4 , 6 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Ocular findings in patients with transfusion-dependent β-thalassemia in southern Iran

et al. 2020

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Background Ocular involvement may occur via several mechanisms in patients with transfusion-dependent β-thalassemia (TDT) mainly chronic anemia, iron overload and iron chelator toxicity. We aimed to evaluate the frequency of abnormal ocular findings and their relationship with hematologic parameters in TDT patients. Methods In this cross-sectional study from January 2018 to January 2019, a total of 79 patients with TDT over the age of 18 who were on iron-chelation therapy (ICT) were consecutively investigated. All patients were registered at the Thalassemia Comprehensive Center affiliated with Shiraz University of Medical Sciences, Shiraz, Southern Iran. Complete ophthalmic examination was performed by an expert ophthalmologist. Clinical and hematologic parameters were collected from the patients´ medical records. Results The mean age ± standard deviation (SD) of the patients was 28.4 ± 5.6 years (range: 18–43). Twenty-four patients (30.4%) were male and 29 (36.7%) were splenectomized. The mean ± SD of the best-corrected visual acuity (VA) was 0.960 ± 0.086 decimal, (range: 0.6–1), 0.016 ± 0.046 logMar, (range: 0–0.2). The frequency of patients with VA > 0.1 logMar was 3 (3.8%). The mean intraocular pressure (IOP) was 14.88 ± 3.34 (6–25) mmHg. Fundus abnormalities were observed in 8 patients (10.1%), consisting of increased cup-disk ratio (3.8%), vessel tortuosity (2.5%), retinal pigment epithelium degeneration (2.5%), myelinated nerve fiber layer (1.3%), and internal limiting membrane wrinkling (1.3%). No significant association was observed between fundus abnormalities, VA, or IOP with hematologic parameters (P > 0.05). TDT patients with diabetes mellitus had significantly higher IOP (P = 0.010) but similar frequency of fundus abnormalities with non-diabetic patients (P > 0.05). Conclusions The frequency of ocular abnormalities in our patients was lower than the previous reports. The frequency of fundus abnormalities were similar in diabetic and non-diabetic thalassemia patients indicating close monitoring and proper management of the disease and comorbidities in these patients.

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Section: Discussioncontrasting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Ocular findings in patients with transfusion-dependent β-thalassemia in southern Iran

et al. 2020

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“…Ocular changes seen included decreased visual acuity (5/30), ocular surface disorder (7/30), lenticular opacity (2/30), blurred optic disc margins (2/30) and dilatation and tortuosity of retinal vessels (4/30), Retinal pigment epithelium mottling (1/30). 6 .…”

Section: Resultsmentioning

confidence: 99%

Ocular Manifestations in Multi-Transfused Children with Beta Thalassemia Receiving Chelating Agents

Arunkumar¹

2019

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To determine prevalence of ocular abnormalities in children with beta thalassemia and assess the ocular side effects of blood transfusion and iron chelating agents. Methods: Cross sectional study undertaken over a period of one year among 30 β Thalassemia major patients from age group of 6 months to 18 years were taken. Full medical history, thorough physical examinations were done to all patients groups, and ophthalmological examination to determine the prevalence of ocular manifestations for all patient groups and to correlate these manifestations or changes with iron chelating agents. Ocular examination including near and distance visual acuity assessment with Snellen's charts, colour vision testing, external examination with diffuse illumination, slit-lamp examination, direct and indirect ophthalmoscopy, schrimer test for tear break up time and ocular biometry will be performed. Results: In 30 patients (16 females and 14 males) with age ranging between 2 years to 18 years. The prevalence of ocular abnormalities was 40%, (12/30). Ocular changes seen included decreased visual acuity 50% (6/12), ocular surface disorder 23%(7/12), lenticular opacity 16.5% (2/12), blurred optic disc margins 16.5% (2/12) and dilatation and tortuosity of retinal vessels 33% (4/12), Retinal pigment epithelium mottling 8%(1/12). The mean serum ferritin and the number of blood transfusions received were higher in children with ocular findings than in those with no ocular manifestations. Conclusion: Ocular findings in beta-thalassemia may correlate to the disease itself, iron overload or the chelating agents used.Children with beta-Thalassemia develop various eye problems and Ocular changes are attributed to the course and severity of the disease. Therefore, beta thalassemia children should be screened periodically to enable early detection and delay of ocular changes.

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