Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition

Ou, Wanmei; Nissilä, Ilkka; Radhakrishnan, Harsha; Boas, David A.; Hämäläinen, Matti S.; Franceschini, Maria Angela

doi:10.1016/j.neuroimage.2009.03.008

Cited by 47 publications

(35 citation statements)

References 69 publications

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“…Similarly, Seki et al 44 looked at auditory function using a custom built unshielded MEG and fNIRS system. A more comprehensive study using conventional MEG was done by Ou et al 45 Ou et al used a median nerve electrical stimulation task to look at the relationships of the fNIRS and MEG signals under a parametric stimulation task. They examined the relationship of the amplitude of the optically measured oxy-and deoxy-hemoglobin signals with respect to various physiological peaks in the MEG signal.…”

Section: Comparision Of Fnirs Fmri and Meg Signalsmentioning

confidence: 99%

Comparison of group-level, source localized activity for simultaneous functional near-infrared spectroscopy-magnetoencephalography and simultaneous fNIRS-fMRI during parametric median nerve stimulation

et al. 2017

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Abstract. Functional near-infrared spectroscopy (fNIRS) is a noninvasive neuroimaging technique, which uses light to measure changes in cerebral blood oxygenation through sensors placed on the surface of the scalp. We recorded concurrent fNIRS with magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) in order to investigate the group-level correspondence of these measures with source-localized fNIRS estimates. Healthy participants took part in both a concurrent fNIRS-MEG and fNIRS-fMRI neuroimaging session during two somatosensory stimulation tasks, a blocked design median nerve localizer and parametric pulsed-pair median nerve stimulation using interpulse intervals from 100 to 500 ms. We found the spatial correlation for estimated activation patterns from the somatosensory task was R ¼ 0.54, 0.57, and −0.48 and the amplitude correlation was R ¼ 0.80, 0.52, and −0.70 for fMRI-MEG, fMRI-fNIRS oxy-hemoglobin, and fMRI-fNIRS deoxy-hemoglobin signals, respectively. Taken together, these results show good correspondence among the fMRI, fNIRS, and MEG with the great majority of the difference across modalities being driven by lower sensitivity for deeper brain sources in MEG and fNIRS. These results provide an important validation of source-localized fNIRS in the context of concurrent multimodal imaging for future studies of the relationship between physiological effects in the human brain.

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Section: Comparision Of Fnirs Fmri and Meg Signalsmentioning

confidence: 99%

Comparison of group-level, source localized activity for simultaneous functional near-infrared spectroscopy-magnetoencephalography and simultaneous fNIRS-fMRI during parametric median nerve stimulation

et al. 2017

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“…For anesthesia-free neural recording, telemetry systems and linear arrays of microelectrodes have been introduced in behaving small animals (Schregardus et al, 2006) and humans (Keller et al, 2009). Electroencephalogram and magnetoencephalogram also provide less-invasive neural measurements and allow concurrent recording with cortical hemodynamics in anesthetized animals (Franceschini et al, 2008) and in conscious humans (Rosengarten and Kaps, 2010;Ou et al, 2009).…”

Section: Why Is Anesthesia Needed?mentioning

confidence: 99%

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Masamoto

Kanno²

2012

J Cereb Blood Flow Metab

242

191

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Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.

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“…While topographic DOI methods remain in wide use (Cui et al, 2011;Franceschini et al, 2006;Khan et al, 2010;Lindauer et al, 2001;Ou et al, 2009;Sakatani et al, 2007;, the image quality improvements of HD-DOT methods have been established by several research groups Koch et al, 2010;Zeff et al, 2007). Quantitative comparative studies, using both simulated and in vivo data, have demonstrated clear improvements in resolution of the tomography approach (Boas et al, 2004a;Boas et al, 2004b;Boas et al, 2001;Koch et al, 2010;White and Culver, 2010b).…”

Section: Discussionmentioning

confidence: 99%

A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping

Eggebrecht

White

Ferradal

et al. 2012

Biomedical Optics and 3-D Imaging

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Functional neuroimaging commands a dominant role in current neuroscience research. However its use in bedside clinical and certain neuro-scientific studies has been limited because the current tools lack the combination of being non-invasive, non-ionizing and portable while maintaining moderate resolution and localization accuracy. Optical neuroimaging satisfies many of these requirements, but, until recent advances in high-density diffuse optical tomography (HD-DOT), has been hampered by limited resolution. While early results of HD-DOT have been promising, a quantitative voxel-wise comparison and validation of HD-DOT against the gold standard of functional magnetic resonance imaging (fMRI) has been lacking. Herein, we provide such an analysis within the visual cortex using matched visual stimulation protocols in a single group of subjects (n=5) during separate HD-DOT and fMRI scanning sessions. To attain the needed voxelto-voxel co-registration between HD-DOT and fMRI image spaces, we implemented subjectspecific head modeling that incorporated MRI anatomy, detailed segmentation, and alignment of source and detector positions. Comparisons of the visual responses found an average localization error between HD-DOT and fMRI of 4.4 +/− 1 mm, significantly less than the average distance between cortical gyri. This specificity demonstrates that HD-DOT has sufficient image quality to be useful as a surrogate for fMRI.

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Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition

Cited by 47 publications

References 69 publications

Comparison of group-level, source localized activity for simultaneous functional near-infrared spectroscopy-magnetoencephalography and simultaneous fNIRS-fMRI during parametric median nerve stimulation

Comparison of group-level, source localized activity for simultaneous functional near-infrared spectroscopy-magnetoencephalography and simultaneous fNIRS-fMRI during parametric median nerve stimulation

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping

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