Study of neurovascular coupling during cold pressor test in patients with migraine

Fabjan, Andrej; Bajrović, Fajko F.; Musizza, Bojan; Vidmar, Jernej; Štrucl, Martin; Zaletel, Marjan

doi:10.1177/0333102414554661

Cited by 9 publications

(15 citation statements)

References 36 publications

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“…Sixteen studies compared MBFV in the posterior circulation of migraineurs and controls. 12 , 19–21,23–26,29,33,35,41,45–47,49 Abernathy et al., Chernyshev et al. and Karadas et al.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-five studies were identified from the literature search that compared resting mean blood flow velocity (MBFV) in migraineurs to controls; 12,16–49 30 studies assessed MBFV in the anterior circulation. 12,19–24,26–32,34–49 All but four studies found no significant difference in MBFV in the anterior circulation between migraineurs and controls; Abernathy et al., Fiermonte et al., Karadas et al. and Kastrup et al.…”

Section: Resultsmentioning

confidence: 99%

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Profiling cerebrovascular function in migraine: A systematic review and meta-analysis

Dzator

Howe

Wong

2020

J Cereb Blood Flow Metab

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Previous studies have investigated whether migraine is a circulatory disorder, as migraineurs are at heightened risk of cerebrovascular disease. However, in most cases, systemic vascular function was evaluated, which may not reflect abnormalities in the cerebral circulation. Therefore, we aimed to determine whether cerebrovascular function differs between migraineurs and controls. A systematic literature search was conducted across three electronic databases to search for studies that compared cerebrovascular function in migraineurs to controls. Where applicable, meta-analyses were used to determine standardised mean differences (SMD) between migraineurs and controls. Seventy articles were identified, 40 of which contained quantitative data. Meta-analyses showed pulsatility index (PI) was higher (SMD = 0.23; 95%CI = 0.05 to 0.42, P = 0.01) and cerebrovascular responsiveness (CVR) to hypercapnia was lower (SMD=−0.34; 95%CI=−0.67 to −0.01, P = 0.04) in the posterior circulation of migraineurs, particularly those without aura. The meta-analyses also indicated that migraineurs have higher resting mean blood flow velocity in both anterior (SMD = 0.14; 95%CI = 0.05 to 0.23, P = 0.003) and posterior circulations (SMD = 0.20; 95%CI = 0.05 to 0.34, P = 0.007). Compared to healthy controls, migraineurs have altered cerebrovascular function, evidenced by elevated PI (representing arterial stiffness) and impaired CVR to hypercapnia (representing cerebral vasodilator function). Future studies should investigate whether improvement of cerebrovascular function is able to alleviate migraine.

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“…Sixteen studies compared MBFV in the posterior circulation of migraineurs and controls. 12 , 19–21,23–26,29,33,35,41,45–47,49 Abernathy et al., Chernyshev et al. and Karadas et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Profiling cerebrovascular function in migraine: A systematic review and meta-analysis

Dzator

Howe

Wong

2020

J Cereb Blood Flow Metab

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“…Nevertheless, appropriate side selection of region of interest is important in studies on NVC in migraine as pathophysiological mechanism might be asymmetrical and therefore more or less lateralized [ 64 ]. Our study has shown that cold pressor test has no effect on VEFR in patients with migraine, whereas in healthy subjects it causes an increase, suggesting dysfunctional NVC in migraine under tonic pain condition [ 65 ]. We have speculated this to be due to dysfunction of subcortical modulatory projections involved in the regulation of microvascular tone.…”

Section: Neurovascular Coupling Between Migraine Attacksmentioning

confidence: 99%

Is There a Persistent Dysfunction of Neurovascular Coupling in Migraine?

Fabjan

Zaletel

Žvan

2015

BioMed Research International

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“…9,10 In contrast, studies of vascular reactivity, including those of the trigeminovascular response, 3,11,12 have shown promise in the study of migraine, with evidence to suggest altered vascular function both extra-and intracranially. [13][14][15] In recent decades, several optical techniques have been developed for noninvasive and noncontact blood perfusion imaging, including laser Doppler flowmetry (LDF), laser speckle contrast techniques, optical imaging, and photoplethysmography; however, recent applications to facial structures have focused on pulsatility 16,17 and surrogate markers for systemic cardiovascular function (heart rate, blood pressure (BP)). [18][19][20] In an effort to better examine intrinsic vascular function of the craniofacial region, we developed a technique adapted from our work in animal model systems, 21,22 utilizing surface imaging to register spontaneous oscillatory hemodynamic changes in the skin (facial cutaneous oscillations (FCOs)) to examine differences in facial blood volume in response to trigeminovascular reflex stimulation, as well as standardized measures of cardiovascular autonomic function (heart rate variability and baroreflex responses).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls

Cortez

Theriot

Rea

et al. 2019

Cephalalgia Reports

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Background: Surface imaging is a promising, noninvasive approach to assess regional perfusion in craniovascular disorders such as migraine. Methods: We used optical imaging to examine differences in facial blood volume at baseline and in response to ammonia inhalation (a noxious stimulus), as well as standardized measures of cardiovascular autonomic function, in healthy, non-headache controls ( n = 43) and in interictal migraine subjects ( n = 22). Results: Resting facial cutaneous oscillation (FCO) frequency was significantly different in migraine compared to healthy controls. Following ammonia inhalation, healthy controls showed a significant increase in resting FCO frequency, whereas this response was not significant in the migraine group. Standardized autonomic reflex parameters did not differ significantly between study groups, and facial cutaneous activity did not correlate with standardized cardiovascular autonomic reflex parameters, suggesting potentially different regulation. Conclusions: This approach to the assessment of craniofacial hemodynamic function appears to exhibit differing mechanisms from previously available techniques, and represents a promising new physiological biomarker for the study of craniofacial vascular function in migraine and potentially other craniovascular disorders.

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Study of neurovascular coupling during cold pressor test in patients with migraine

Abstract: The absence of the effect of CPT on VEFR in migraine is likely to be a consequence of impaired subcortical modulation of neurovascular coupling.

Cited by 9 publications

References 36 publications

Profiling cerebrovascular function in migraine: A systematic review and meta-analysis

Profiling cerebrovascular function in migraine: A systematic review and meta-analysis

Is There a Persistent Dysfunction of Neurovascular Coupling in Migraine?

Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls

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