Study of Monoclonal Antibody Aggregation at the Air–Liquid Interface under Flow by ATR-FTIR Spectroscopic Imaging
Céline van Haaren,
Bernadette Byrne,
Sergei G. Kazarian
Abstract:Throughout bioprocessing, transportation, and storage,
therapeutic
monoclonal antibodies (mAbs) experience stress conditions that may
cause protein unfolding and/or chemical modifications. Such structural
changes may lead to the formation of aggregates, which reduce mAb
potency and may cause harmful immunogenic responses in patients. Therefore,
aggregates need to be detected and removed or ideally prevented from
forming. Air–liquid interfaces, which arise during various
stages of bioprocessing, are one of the … Show more
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