Study of method validation criteria in a capillary electrophoresis method for the separation of non-steroidal anti-inflammatory drugs

Toasaksiri, S; Massart, D.L.; Heyden, Yvan Vander

doi:10.1016/s0003-2670(00)00882-5

Cited by 31 publications

(16 citation statements)

References 27 publications

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“…Tetraborate sodium anhydrous aqueous buffer was chosen to study the effect of ionic strength in the applied voltage range of 10-30 kV [1,8,32]. Under these conditions, some NSAIDs were not baseline-separated.…”

Section: Separation Of Nsaids By Nonaqueous Cementioning

confidence: 99%

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

et al. 2003

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Large-volume sample stacking using the electroosmotic flow (EOF) pump (LVSEP) has been used to analyze some nonsteroidal anti-inflammatory drugs (NSAIDs) in water samples. With methanol as the run buffer solvent to suppress the EOF, sensitivity was enhanced by 80-100-fold. The sample for the analysis of real water sample was pretreated by solid-phase extraction (SPE). When the method was based on off-line SPE-LVSEP-CE, sensitivity improved by as much as 1000 times.

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Section: Separation Of Nsaids By Nonaqueous Cementioning

confidence: 99%

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

et al. 2003

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“…Numerous types of surfactants can be used in MEKC, but SDS is one of the most commonly used [5,6,10,11,[18][19][20][21][22]. In MEKC, selectivity can easily be manipulated.…”

Section: Surfactant Concentrationmentioning

confidence: 99%

“…Different approaches can be used in the robustness testing, such as one-variable-at-a-time (OVAT) procedure, fractional factorial designs, and Plackett-Burman designs [5][6][7][8][9][10]. The OVAT procedure varies the levels of a given parameter while keeping the other factors at nominal levels.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of robustness between micellar electrokinetic capillary chromatography and high-performance liquid chromatography using one-variable-at-a-time and a new multi-variable-at-a-time approach

Injac

Bošković

Kočevar

et al. 2008

Analytica Chimica Acta

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“…respect to linearity, limit of detection and quantitation, precision, accuracy, robustness, and specificity (ICH 1995;Toasaksiri et al 2000).…”

Section: Validationmentioning

confidence: 99%

Optimization, Validation and Application of a Capillary Zone Electrophoresis Method for the Assay of Sparfloxacin in Pharmaceutical Formulation

et al. 2008

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A capillary zone electrophoresis (CZE) method has been developed for the determination of the antibiotic sparfloxacin in tablets. The CZE separation was performed using 75 mmÂ35 cm fused-silica capillary under the following conditions: 25 C; applied voltage, 12 kV; 25 mM H 3 PO 4 -NaOH running buffer (pH 8.5). The detection wavelength was 254 nm. Flumequine was used as internal standard (IS). The method was suitably validated with respect to linearity, limit of detection and quantification, accuracy, precision, specificity, and robustness. The calibration was linear from 10 to 60 mg mL À1 and the limit of detection and quantification were 5.38 and 9.46 mg mL À1 , respectively. Recoveries ranging from 95.68%-102.4% were obtained in the determination of sparfloxacin that were spiked to placebos. Excipients in the commercial tablets and degraded products from different stress conditions did not interfere in the assay. The

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Study of method validation criteria in a capillary electrophoresis method for the separation of non-steroidal anti-inflammatory drugs

Cited by 31 publications

References 27 publications

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples

Comparative study of robustness between micellar electrokinetic capillary chromatography and high-performance liquid chromatography using one-variable-at-a-time and a new multi-variable-at-a-time approach

Optimization, Validation and Application of a Capillary Zone Electrophoresis Method for the Assay of Sparfloxacin in Pharmaceutical Formulation

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