Study of Metastasis in Lymphnode Biopsies with Special Reference to Immunohistochemistry (IHC) in Metastatic Breast Carcinoma

Hussaini, Syed Ali Baqher

doi:10.7860/jcdr/2015/12179.5679

Cited by 4 publications

(11 citation statements)

References 10 publications

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“…Axillary nodes remain the most preferable lymph drainage of the breast underscoring the high incidence of axillary LN metastasis in BC patients. 35,46,48 This might have explained why there was a significant correlation in the LN involvement with chest metastasis. Although the preferential lymph drainage of the breast is to the axillary nodes, nodal involvement at distant sites, including the AP, may occur in more local or intra-abdominal nodes.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from previous studies may suggest that liver and pancreatic metastasis are major causes of the spread of invasive tumor cells to LNs in the AP region 12,49 . Secondary drainage for most AP tumors occur via the porta hepatis, common hepatic, coeliac, and mesenteric root LNs 12,46 . The vascular mechanism and lymphatic involvement therefore encourage the spread of invasive cancer cells to the lymphatic drainage system 46,47,49 …”

Section: Discussionmentioning

confidence: 99%

“…Consistent with existing studies, 2,47 the majority of our study sample with chest metastasis involved the axillary LN. Axillary nodes remain the most preferable lymph drainage of the breast underscoring the high incidence of axillary LN metastasis in BC patients 35,46,48 . This might have explained why there was a significant correlation in the LN involvement with chest metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…12,49 Secondary drainage for most AP tumors occur via the porta hepatis, common hepatic, coeliac, and mesenteric root LNs. 12,46 The vascular mechanism and lymphatic involvement therefore encourage the spread of invasive cancer cells to the lymphatic drainage system. 46,47,49 The key limitations noted were the sample size, number of sub-…”

Section: Discussionmentioning

confidence: 99%

“…12,46 The vascular mechanism and lymphatic involvement therefore encourage the spread of invasive cancer cells to the lymphatic drainage system. 46,47,49 The key limitations noted were the sample size, number of sub-…”

Section: Discussionmentioning

confidence: 99%

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Radiologic patterns of distant organ metastasis in advanced breast cancer patients: Prospective review of computed tomography images

Jimah,

Amoako,

Ofori

et al. 2024

Cancer Reports

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BackgroundBreast cancer (BC) metastases to the abdomen and pelvis affect the liver, mesentery, retroperitoneum, peritoneum, bladder, kidney, ovary, and uterus. The study documented the radiological pattern and features of the chest, bone, abdominal and pelvic (AP) metastases among advanced BC patients.AimThe aim is to document the radiological pattern and features of breast cancer metastasis in the chest, abdomen, pelvis and bones.Materials and ResultsChest, abdominal, and pelvic computed tomography scan images of 36 patients with advanced BC were collated from Cape Coast Teaching Hospital and RAAJ Diagnostics. The images were prospectively assessed for metastasis to the organs of the chest, AP soft tissues, and bones. Radiologic features of metastasis of the lungs, liver, lymph nodes (LNs), and bones were documented. Patients' demographics, clinical data, and histopathology reports were also collected. The data were captured using UVOSYO and exported to Microsoft Excel templates. The data obtained were descriptively analyzed. Only 2.8% of BCs exhibited metaplastic BC, whereas 97.2% had invasive ductal BC. Triple‐negative cases were 55.6%. Of 36 patients, 31 (86.1%), 21 (58.3%), and 14(38.8%) were diagnosed of chest, AP, and bone tissues metastasis, respectively. LN involvement was reported in 26 (72.2%) patients. Majority, 21 (58.3%) were diagnosed of multiple sites metastasis with 15 (41.7%) showing single site. Lungs (77.4%, 24/31) and liver (47.6%, 10/21) were the most affected distant organs. Most bone metastases were lytic lesions (92.9%, 13/14) with the vertebrae (85.7%, 12/14) been the most affected.ConclusionAccording to the study, advanced BC patients have a higher‐than‐average radiologic incidence of lung, liver, bone, and LN metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Radiologic patterns of distant organ metastasis in advanced breast cancer patients: Prospective review of computed tomography images

Jimah,

Amoako,

Ofori

et al. 2024

Cancer Reports

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Metastatic and non-metastatic lymph nodes: quantification and different distribution of iodine uptake assessed by dual-energy CT

Rizzo

Radice²,

Femia

et al. 2017

Eur Radiol

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Radiologic patterns of distant organ metastasis in advanced breast cancer patients: prospective review of CT images.

Jimah,

Amoako,

Ofori

et al. 2023

Preprint

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Background: Breast cancer (BC) metastases to the abdomen and pelvis affect the liver, mesentery, retroperitoneum, peritoneum, bladder, kidney, ovary, and uterus. The study documented the radiological pattern and features of the chest, bone, abdominal and pelvic (AP) metastases among advanced breast cancer patients. Materials and Methods: Chest, abdominal and pelvic Computed Tomography (CT) scan images of 36 patients with ABC were collated from Cape Coast Teaching Hospital and RAAJ Diagnostics. The images were prospectively assessed for metastasis to the organs of the chest, AP soft tissues and bones. Radiologic features of metastasis of the lungs, liver, lymph nodes (LN), and bones were documented. Patients’ demographics, clinical data and histopathology reports were also collected. The data was captured using Uvosyo and exported to Microsoft Excel templates. The data obtained were descriptively analyzed. Results: Only 2.8% of BCs exhibited metaplastic BC, while 97.2% had invasive ductal BC. Triple-negative cases was 55.6%. Of 36 patients, 31 (86.1%), 21 (58.3%) and 14(38.8%) were diagnosed of chest, AP and bone tissues metastasis, respectively. LN involvement was reported in 26 (72.2%) patients. Majority, 21 (58.3%) were diagnosed of multiple sites metastasis with 15 (41.7%) showing single site. Lungs (77.4%, 24/31), and liver (47.6%, 10/21) were the most affected distant organs. Most bone metastases were lytic lesions (92.9%, 13/14) with the vertebrae (85.7%, 12/14) been the most affected. Conclusion: According to the study, advanced breast cancer patients have a higher-than-average radiologic incidence of lung, liver, bone, and lymph node metastases.

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Study of Metastasis in Lymphnode Biopsies with Special Reference to Immunohistochemistry (IHC) in Metastatic Breast Carcinoma

Cited by 4 publications

References 10 publications

Radiologic patterns of distant organ metastasis in advanced breast cancer patients: Prospective review of computed tomography images

Radiologic patterns of distant organ metastasis in advanced breast cancer patients: Prospective review of computed tomography images

Metastatic and non-metastatic lymph nodes: quantification and different distribution of iodine uptake assessed by dual-energy CT

Radiologic patterns of distant organ metastasis in advanced breast cancer patients: prospective review of CT images.

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