Study of MET protein levels andMETgene copy number in 72 sinonasal intestinal-type adenocarcinomas

Abstract

MET is overproduced in about two third of ITACs, suggesting a role for the MET signaling pathway in the oncogenesis of these tumors.

WITHDRAWN: A meta-analysis of c-Met expression in head and neck cancer

“…After title and abstract checking, 36 studies remained for the further evaluating in details, in which 15 articles were excluded for there were no enough data to calculate the survival rate [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27], one article was removed because of duplication [28]. So, a total of 20 publications were fulfilled the eligibility criteria [5][6][7][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45].…”

Intestinal‐type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment

“…Gain of chromosome 7 (polysomy) indicates MET overproduction. One recent study shows that the MET protein was overproduced in 64% of all ITAC cases, suggesting a role for the MET signaling pathway in the ITAC tumorigenesis …”

Intestinal-Type Adenocarcinoma: Classification, Immunophenotype, Molecular Features and Differential Diagnosis

“…In contrast to colorectal carcinomas, activating mutations in KRAS and BRAF oncogenes are rare in ITAC [ 19 , 21 – 23 ]. Overexpression of MET protein without MET gene amplification is frequent in ITAC, but not in intestinal carcinomas, and may provide opportunities for targeted therapies [ 24 ]. Loss of annexin A1 expression and diminished A2 expression has been reported in ITAC [ 25 ].…”