Study of long effects of administration of aspirin (acetylsalicylic acid) on bone in broiler chickens

Derakhshanfar, Amin; Kheirandish, Reza; Alidadi, Soodeh; Bidadkosh, Arash

doi:10.1007/s00580-012-1550-2

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…Short-term acetyl-salicylic acid treatment -less than or equal to 50 mg kg -1 dose is safe in every examined bird species. Nevertheless the five day long application of this agent can cause lesions in the intestinal mucosa as well as severe congestion and hemorrhages in the small intestine (Mohan 2012), furthermore the long-term application of acetyl-salicylic acid can lead irreversible degenerative changes in bone (Derakhshanfar 2013). Pozniak et al (2010) reported that an increase in kidney size was evident in chickens treated with ASA at the dose of 200 mg/kg, which was the highest dose used in that experiment.…”

Section: Blood Biochemistrymentioning

confidence: 99%

Toxicological risk assessment of Acetylsalicylic acid (ASA) in pigeons (columba levia)

Khan¹,

Ali²,

Ali³

et al. 2019

Azarian J Agric

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The current study was aimed to investigate the effect of acetylsalicylic acid on pigeon birds. For this purpose healthy pigeons of different weights were randomly selected from Bio-Park University of Malakand and then placed it in different groups on the basis of their weighs. To observe the effect, different doses of acetylsalicylic acid were administered orally to each group of pigeons except one group which was kept as unmedicated (control group). Blood samples were collected from individual pigeon of each group periodically i.e. before medication, during medication and after medication and were analyzed for glucose, cholesterol, alanine amino tranferase (ALT) and uric acid. Blood hematology was also performed for each individual pigeon from all the groups. A significant decrease was observed in glucose and ALT level, while the cholesterol and uric acid level was increased. Likewise to glucose, reasonable increase was observed in total red blood cells count (TRBCs), Hematocrit value (HCT), Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), Mean corpuscular Hemoglobin concentration (MCHC) and platelets count, while the Hemoglobin (Hb%) and total leukocyte count (TLC) level was decrease. Overall huge toxic effect of acetylsalicylic acid was recorded in pigeons; therefore it should be used carefully in veterinary medicines especially for the treatment of temperature and pain in game birds.

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Section: Blood Biochemistrymentioning

confidence: 99%

Toxicological risk assessment of Acetylsalicylic acid (ASA) in pigeons (columba levia)

Khan¹,

Ali²,

Ali³

et al. 2019

Azarian J Agric

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“…Evidence shows that 12.5 billion birds worldwide have leg problems each year ( Almeida Paz et al, 2010 ). Derakhshanfar et al found that TD affects the skeletal system of 30% of meat chickens and 90% of turkeys ( Derakhshanfar et al, 2013 ). In addition, the abnormalities of growth and development of the skeleton in poultry indirectly lead to reduce gross profits (about 10%–40%) in the poultry industry ( Almeida Paz et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated Fecal Microbiome and Metabolomics Reveals a Novel Potential Biomarker for Predicting Tibial Dyschondroplasia in Chickens

Huang

Zhang

et al. 2022

Front. Physiol.

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Tibial dyschondroplasia (TD) is a metabolic tibial-tarsal disorder occurring in fast-growing poultry, and its diagnosis is mainly based on an invasive method. Here, we profiled the fecal gut microbiome and metabolome of broilers with and without TD to identify potential non-invasive and non-stress biomarkers of TD. First, TD broilers with the most pronounced clinical signs during the experiment were screened and faecal samples were collected for integrated microbiome and metabolomics analysis. Moreover, the diagnostic potential of identified biomarkers was further validated throughout the experiment. It was noted that the microbial and metabolic signatures of TD broilers differed from those of normal broilers. TD broilers were characterized by enriched bacterial OTUs of the genus Klebsiella, and depleted genera [Ruminococcus], Dorea, Ruminococcus, Oscillospira, Ochrobactrum, and Sediminibacterium. In addition, a total of 189 fecal differential metabolites were identified, mainly enriched in the purine, vitamin and amino acid metabolism, which were closely associated with differential microbiota and tibia-related indicators. Furthermore, three fecal metabolites were screened, including 4-hydroxybenzaldehyde, which distinguished TD from normal broilers with extremely high specificity and was superior to serum bone markers. These results indicated that gut microbiota equilibrium might influence the pathogenesis of TD by modulating host metabolism, and the identified fecal metabolite 4-hydroxybenzaldehyde might be a potential and non-invasive biomarker for predicting TD in chickens.

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Use of acetylsalicylic acid as a feed additive in poultry nutrition

Alagawany

Farag

El‐Hack

et al. 2017

World's Poultry Science Journal

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Study of long effects of administration of aspirin (acetylsalicylic acid) on bone in broiler chickens

Cited by 5 publications

References 17 publications

Toxicological risk assessment of Acetylsalicylic acid (ASA) in pigeons (columba levia)

Toxicological risk assessment of Acetylsalicylic acid (ASA) in pigeons (columba levia)

Integrated Fecal Microbiome and Metabolomics Reveals a Novel Potential Biomarker for Predicting Tibial Dyschondroplasia in Chickens

Use of acetylsalicylic acid as a feed additive in poultry nutrition

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