Study of lipophilicity and application of selected structural descriptors in QSAR analysis of nicotinic acid derivatives. Investigations on RP18WF254 plates. Part II

Pyka, Alina; Klimczok, W.

doi:10.1556/jpc.18.2005.4.9

Cited by 16 publications

(4 citation statements)

References 17 publications

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“…The application of various linear regression models [13], principal component analysis [14], cluster analysis [15], and discriminant analysis [16] has been previously reported.…”

Section: Introductionmentioning

confidence: 99%

A quantitative peptide structure vs. retention relationship study

Oros

Cserháti

2008

J of Separation Science

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A quantitative peptide structure vs. retention relationship studyThe quantitative relationship between the TLC retention parameters of 28 short peptides and their physicochemical characteristics was calculated using linear regression analysis. It was established that surface parameters exert a significant impact on the retention of peptides and the ratio of non-polar surface area/polar surface area exerts the highest influence on the retention. This result may be due to the fact that peptides turn towards the apolar surface of the stationary phase with their non-polar substructures while the polar molecular parts point into the hydrophilic mobile phase.

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“…The application of various linear regression models [13], principal component analysis [14], cluster analysis [15], and discriminant analysis [16] has been previously reported.…”

Section: Introductionmentioning

confidence: 99%

A quantitative peptide structure vs. retention relationship study

Oros

Cserháti

2008

J of Separation Science

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“…Documented work on TLC analysis of vitamins reveals that most studies have been performed using methanol, ethanol, butanol, acetone, chloroform, ammonia, pyridine, benzene, and toluene as one of the components of the mobile phase in combination with adsorbents such as silica gel, heulandite, LiChrospher, cellulose, and surface-modified silica gel [8][9][10][11][12][13]. For reversed-phase TLC of hydrophilic and lipophilic vitamins, kieselguhr and cellulose impregnated with 10% paraffin oil [14,15], and RP-18 [5] and RP18WF 254 HPTLC plates [16] have been used with mixed aqueous-organic mobile phases. Perisic-Janjic et al have analysed fat-soluble vitamins on starch, cellulose, and talc thin layers impregnated with paraffin oil using two different solvents -water-dioxane-acetone-formaldehyde and acetone-concentrated acetic acid [17].…”

Section: Introductionmentioning

confidence: 99%

Specific separation of thiamine from hydrophilic vitamins with aqueous dioxane on precoated silica TLC plates

Mohammad¹,

Zehra²

2008

Acta Chromatographica

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Specific separation of thiamine hydrochloride from riboflavin, nicotinic acid, calcium D-pantothenate, pyridoxine hydrochloride, cyanocobalamin, and ascorbic acid has been achieved on commercial precoated silica gel 60F 254 TLC plates with dioxanewater 1:1 (v/v) as mobile phase. The spots were visualized under UV light. The effect of impurities (metal cations and inorganic anions) on the chromatography of thiamine hydrochloride was examined. The detection limit for thiamine hydrochloride was 0.09 μg per spot and the relative standard deviation of the R F value of thiamine hydrochloride in five analyses was 14.99%. The applicability of the method to the identification of thiamine in pharmaceutical formulations was also tested.

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“…Literature is rich in research articles investigating similarities/dissimilarities between log P and chromatographic retention. Determination of partition coefficient using the classical "shake-flask" technique has a series of disadvantages and has been successfully replaced by alternative chromatographic methods, since the partition coefficient (lipophilicity) of a compound between aqueous and organic phase determines both its permeation through biological membranes and retention in RP LC [17][18][19][20][21][22][23][24].…”

mentioning

confidence: 99%

Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids

Podunavac-Kuzmanovic

Jevric

Tepić

et al. 2013

Hem Ind

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Influence of chemical structure on the lipophilicity of isolated free carotenoids from paprika oleoresin was studied by a quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by reversed phase high-pressure liquid chromatography (RP HPLC). The retention mechanism was determined using acetone-water as the mobile phase on a reversed-phase column (SB-C18). A variety of lipophilicity parameters (log P) were calculated using different software products. Based on the correlations, nonlinear structure-activity models were derived between the retention constants, t r (retention time of investigation compounds) and log P values. Five high quality QSRR models were found to have a good predictive ability and close agreement between experimental and predicted values. The study showed that the retention constants can be used as a measure of lipophilicity of investigated compounds at a high significant level.

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Study of lipophilicity and application of selected structural descriptors in QSAR analysis of nicotinic acid derivatives. Investigations on RP18WF254 plates. Part II

Cited by 16 publications

References 17 publications

A quantitative peptide structure vs. retention relationship study

A quantitative peptide structure vs. retention relationship study

Specific separation of thiamine from hydrophilic vitamins with aqueous dioxane on precoated silica TLC plates

Reversed-phase HPLC retention data in correlation studies with in lipophilicity molecular descriptors of carotenoids

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