Study of lipid profile in acute myocardial infarction within 24 hours

Abstract

Background: Increased level of total cholesterol and LDL-cholesterol disturbs the endothelial function that may cause various cardio vascular disease and coronary heart disease. In addition, it can be expected, that hypercholesterolemia may unfavourably influence the course of the acute myocardial infarction. The aim of the study was to check whether patients with lipid levels above normal first 24 hours of myocardial infarction have an unfavorable clinical outcome. Methods: Study was designed on 60 patients (46-men and14-women) of different age groups admitted with myocardial infarction within first 24 hours of onset of symptoms. 20 normal healthy individuals with normal ECG and no family history of coronary heart disease were selected as control. The clinical history and physical examination confirmed the AMI by the cardiac specific enzyme Creatine Kinase (CK) and Creatine Kinase myocardial b fraction (CK-MB), Troponin (T) and ECG. Blood samples were taken within 24 hours of acute myocardial infarction. Serum concentration of TC, TG, HDL-C were estimated by semi auto analyser. Analysis of variance (ANOVA) followed by Tukey's post hoc test was done to evaluate the association between the mean values of serum samples and clinical outcome. A probability value p < 0.05 was considered statistically significant.

The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review

“…Farvin et al in 2006 reported that SQ had significantly decreased the level of cholesterol, TG, free fatty acids, phospholipids, and LDL-C in MI-induced rats from the blood sampling performed at 24 h after the last MI induction [55]. Several previous studies have reported that, within 24 h of MI, most of the patients had high levels of TC, TG, and LDL-C and low levels of HDL-C [101][102][103]. This indicated that SQ possesses hypolipidemic property to improve the lipid profile in acute MI patients within 24 h onset of MI.…”

Long-Term Effects of Critical Care Insults on Lipoprotein Metabolism

“…Acute changes in lipoproteins do not follow a "typical" pattern of change considering the fact that serum HDL-lipoprotein levels were not depressed during acute illness [55][56][57]. LDL-c was lower during acute ACS, but it is unclear how long these changes persisted [55][56][57]. This lipid profile predicted mortality acutely, but these findings are inconsistent with other studies demonstrating depression of LDL-c and HDL-c during acute phase of CCI [58].…”

“…Despite numerous studies demonstrating the pivotal role of lipoprotein profile abnormalities in the development of atherosclerosis and the increased risk of acute coronary syndrome (ACS), little is known regarding how ACS as CCI affects the progress of atherosclerosis [9,10]. Acute changes in lipoproteins do not follow a "typical" pattern of change considering the fact that serum HDL-lipoprotein levels were not depressed during acute illness [55][56][57]. LDL-c was lower during acute ACS, but it is unclear how long these changes persisted [55][56][57].…”