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Abstract. Endogenous intoxication plays a significant role in the pathogenesis of many diseases. The erythrocyte intoxication index and molecular weight medium are informative indicators for its research. The goal is to establish the degree of expression of endogenous intoxication syndrome in white rats against the background of drinking water with different phosphate content for 30 days. Materials and methods. The study was conducted on 36 white purebred male rats weighing 180-200 g, divided into six groups, which for 30 days consumed: the control group – settled water from the city waterworks, the animals of five experimental groups - water with the addition of sodium monophosphate in doses of 100.0; 10.0; 1.0; 0.1; 0.01; mg/dm3 in terms of elemental phosphorus. The level of endogenous intoxication was estimated by the content of molecular weight medium in blood serum at wavelengths λ = 254 and 280 nm and the level of erythrocyte intoxication index, which was determined using the method of A. A. Togaibaev, et al., which is based on the ability of the erythrocyte membrane to absorb methylene blue. Results. It was established that the content of molecular weight medium 254 in the blood serum of experimental animals significantly increased in the 1st group by 65 % (p < 0.05), the content of molecular weight medium 280 in the 1st group by 154 % (p < 0.05), in the 2nd – by 138 % (p < 0.05) and the 3rd – by 64 % (p < 0.05). Consumption of drinking water with added phosphates leads to a significant increase of erythrocyte intoxication index in the 1st group – by 186 % (p < 0.05), in the 2nd – by 142 % (p < 0.05) compared to the control. Conclusions. Consumption of drinking water with different phosphate content for 30 days causes an increase in the level of endogenous intoxication in the body of experimental rats, as indicated by an increase in the permeability of erythrocyte membranes and an increase in the erythrocyte intoxication index and molecular weight medium content, most pronounced at a concentration of 100.0 mg/dm3.
Abstract. Endogenous intoxication plays a significant role in the pathogenesis of many diseases. The erythrocyte intoxication index and molecular weight medium are informative indicators for its research. The goal is to establish the degree of expression of endogenous intoxication syndrome in white rats against the background of drinking water with different phosphate content for 30 days. Materials and methods. The study was conducted on 36 white purebred male rats weighing 180-200 g, divided into six groups, which for 30 days consumed: the control group – settled water from the city waterworks, the animals of five experimental groups - water with the addition of sodium monophosphate in doses of 100.0; 10.0; 1.0; 0.1; 0.01; mg/dm3 in terms of elemental phosphorus. The level of endogenous intoxication was estimated by the content of molecular weight medium in blood serum at wavelengths λ = 254 and 280 nm and the level of erythrocyte intoxication index, which was determined using the method of A. A. Togaibaev, et al., which is based on the ability of the erythrocyte membrane to absorb methylene blue. Results. It was established that the content of molecular weight medium 254 in the blood serum of experimental animals significantly increased in the 1st group by 65 % (p < 0.05), the content of molecular weight medium 280 in the 1st group by 154 % (p < 0.05), in the 2nd – by 138 % (p < 0.05) and the 3rd – by 64 % (p < 0.05). Consumption of drinking water with added phosphates leads to a significant increase of erythrocyte intoxication index in the 1st group – by 186 % (p < 0.05), in the 2nd – by 142 % (p < 0.05) compared to the control. Conclusions. Consumption of drinking water with different phosphate content for 30 days causes an increase in the level of endogenous intoxication in the body of experimental rats, as indicated by an increase in the permeability of erythrocyte membranes and an increase in the erythrocyte intoxication index and molecular weight medium content, most pronounced at a concentration of 100.0 mg/dm3.
Objective. To investigate pathogens in peritonitis. Materials and methods. In 2021 yr in Department of Surgery of Brovary Multidisciplinary Clinical Hospital were treated 360 patients with an acute peritonitis of various genesis: 186 (51.7%) women and 174 (48.3%) men. Results. In the patients 391 strains of microorganisms, which are optionally-anaerobic and aerobic of Gram-negative and Gram-positive pathogens were isolated: Escherichia coli – in 144 (36.8%), Streptococcus spp. – 52 (13.3%), Enterococcus faecalis – 47 (12.0%), Staphylococcus aureus – 37 (9.5%), Klebsiella pneumoniae – 31 (7.9%), Citrobacter – 25 (6.4%), Staphylococcus haemolyticus – 23 (5.9%), Pseudomonas aeruginosa – 14 (3.6%), Acinetobacter baumannii – 13 (3.3%), and Proteus mirabilis – 5 (1.3%) strains. Conclusion. Majority of microorganisms, isolated in patients, suffering peritonitis, was characterized by significant antibiotic resistance. Most frequently Escherichia coli was sowed – 36.8%. All strains of Escherichia coli isolated were resistant to vancomycine, clindamycine and linezolide.
Objective. Studying of rate and structure of peritonitis of various genesis. Materials and methods. During 2020 yr in the Department of Surgery of Brovary Multidisciplinary Clinical Hospital 265/1316 (20.1%) patients, including 124 (47,8%) women and 141 (53,2%) men, suffering peritonitis, were operated. Results. Appendicitis have constituted a most frequent cause of local and diffuse peritonitis – in 71.5 and 92.3% patients, accordingly. Spread peritonitis in 55.2% patients was caused by perforative gastric or duodenal ulcer. Total peritonitis was present in 35.7% of cases and caused by abdominal trauma mainly. Treatment of spread forms of peritonitis (prevalent, diffuse and a total one) was conducted in 121 (45.7%) patients, suffering this disease. Conclusion. It is mandatory to take into account the peritonitis spread, cause, stage and character of exudate while planning preoperative preparation, surgery and the postoperative treatment volume in patients with this disease.
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