Study of Laser Radiation Effect on the Cornea of the Eye by Speckle Interferometry

Fedulova, Victoria A.; Yuzhakov, Aleksei V.; Baum, Olga I.

doi:10.18287/jbpe20.06.010302

Cited by 3 publications

(1 citation statement)

References 25 publications

(28 reference statements)

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“…When studying through OCT elastography, initially, for reducing the impact of tissues structures anisotropy and prevention from valuable biological material use during experiments, the phantoms -(PAAG), simulating the temperature properties and homogeneous structure of cartilaginous tissue [16], with solutions of nanoparticles of Na 0.2 TiO 2 , Fe 3 O 4 and PAAG reference sample without nanoparticles were used as samples.…”

Section: Introductionmentioning

confidence: 99%

Deformation response of biological phantoms and cartilaginous tissue at laser exposure

Kasianenko

Omelchenko

Baum

2022

Optics and Spectroscopy

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Regeneration of cartilaginous tissue and its shape change at laser exposure can be used as a basis for prospective medical operations, improving patient's quality of life. The most important criterion of such operations success is a cell survival after laser exposure, therefore reduction of exposure duration and power is an important task at such methods development. Nanoparticles are actively used in medicine, and one of their intended usages is photothermal effect enhancement at laser exposure to biological tissue. However, articular tissue is quite resistant to foreign agents penetration, therefore the study of nanoparticles penetration capability and their impregnation effect is the priority task for achieving the desired medical effect. Optical coherence tomography (OCT) of gel phantoms and cartilaginous tissue of a joint, impregnated with nanoparticles, at laser exposure with erbium fiber laser with length wave of 1.56 μm is performed in this study. Articular cartilaginous tissue sections of three types (intact, with laser damage and after low laser exposure) were impregnated with nanoparticles of Fe3O4 for further study using OCT elastography. Increase of deformations, caused by heating of phantoms and tissue, impregnated with nanoparticles, is observed. OCT elastography data indicate the dependence of tissue deformation on previous tissue exposure history. The work substantiates increase of photothermal impact of laser exposure to tissue deformation at various nanoparticles introduction. Keywords: nanoparticles, OCT elastography, biological tissue laser modification, biophotonics.

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Section: Introductionmentioning

confidence: 99%

Deformation response of biological phantoms and cartilaginous tissue at laser exposure

Kasianenko

Omelchenko

Baum

2022

Optics and Spectroscopy

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Deformation Response of Biological Phantoms and Cartilaginous Tissue at Laser Exposure

Kas’yanenko,

Omel’chenko,

Baum

2023

Opt. Spectrosc.

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Spatio-Temporal Dynamics of Diffusion-Associated Deformations of Biological Tissues and Polyacrylamide Gels Observed with Optical Coherence Elastography

et al. 2023

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In this work, we use the method of optical coherence elastography (OCE) to enable quantitative, spatially resolved visualization of diffusion-associated deformations in the areas of maximum concentration gradients during diffusion of hyperosmotic substances in cartilaginous tissue and polyacrylamide gels. At high concentration gradients, alternating sign, near-surface deformations in porous moisture-saturated materials are observed in the first minutes of diffusion. For cartilage, the kinetics of osmotic deformations visualized by OCE, as well as the optical transmittance variations caused by the diffusion, were comparatively analyzed for several substances that are often used as optical clearing agents, i.e., glycerol, polypropylene, PEG-400 and iohexol, for which the effective diffusion coefficients were found to be 7.4 ± 1.8, 5.0 ± 0.8, 4.4 ± 0.8 and 4.6 ± 0.9 × 10−6 cm2/s, respectively. For the osmotically induced shrinkage amplitude, the influence of the organic alcohol concentration appears to be more significant than the influence of its molecular weight. The rate and amplitude of osmotically induced shrinkage and dilatation in polyacrylamide gels is found to clearly depend on the degree of their crosslinking. The obtained results show that observation of osmotic strains with the developed OCE technique can be applied for structural characterization of a wide range of porous materials, including biopolymers. In addition, it may be promising for revealing alterations in the diffusivity/permeability of biological tissues that are potentially associated with various diseases.

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Study of Laser Radiation Effect on the Cornea of the Eye by Speckle Interferometry

Cited by 3 publications

References 25 publications

Deformation response of biological phantoms and cartilaginous tissue at laser exposure

Deformation response of biological phantoms and cartilaginous tissue at laser exposure

Deformation Response of Biological Phantoms and Cartilaginous Tissue at Laser Exposure

Spatio-Temporal Dynamics of Diffusion-Associated Deformations of Biological Tissues and Polyacrylamide Gels Observed with Optical Coherence Elastography

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