Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods

Nabi, Arshid; Tasneem, Shadma; Jesudason, Christopher G.; Lee, Vannajan Sanghiran; Zain, Sharifuddin Bin Md

doi:10.1016/j.molliq.2018.01.185

Cited by 37 publications

(15 citation statements)

References 40 publications

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“…We observed the lower values of G min in SDS-rich and DTAB-rich systems. The observed lower values of G min ascertain the thermodynamic stability [55]. Since the obtained G min values are lower in magnitude (table 3), it can be inferred that thermodynamically stable surfaces are formed with synergistic interaction [56].…”

Section: Resultsmentioning

confidence: 99%

Self-assembly of sodium dodecylsulfate and dodecyltrimethylammonium bromide mixed surfactants with dyes in aqueous mixtures

et al. 2019

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The micellar property of mixed surfactant systems, cationic (dodecyltrimethylammonium bromide, DTAB) and anionic (sodium dodecylsulfate, SDS) surfactants with variable molar ratios in aqueous system has been reported by using surface tension and conductivity measurements at T = 293.15, 298.15 and 303.15 K. DTAB concentrations are varied from 1.0 × 10 −4 to 3 × 10 −4 mol l −1 in 1.0 × 10 −2 mol l −1 SDS solution while the SDS concentration is varied from 1.0 × 10 −3 to 1.5 × 10 −2 mol l −1 in approximately 5.0 × 10 −3 mol l −1 DTAB, so that such concentrations of DTAB-SDS (DTAB-rich) and SDS-DTAB (SDS-rich) solutions were chosen 3 : 1 ratio. The critical micellar concentration, as well as surface and thermodynamic properties for DTAB-rich and SDS-rich solutions, were evaluated by the surface tension ( γ ) and conductivity ( κ ) methods. The pseudo phase separation model was coupled with the dissociated Margules model for synergism. The Krafft temperature behaviour and optical analysis of mixed surfactants are studied using conductivity and UV–Vis spectroscopy, respectively. The dispersibility and stability of DTAB-rich and SDS-rich solutions with and without dyes (2.5 × 10 −5 mol l −1 of methyl orange and methylene blue) are carried out by using UV–Vis spectroscopy and dynamic light scattering.

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Section: Resultsmentioning

confidence: 99%

Self-assembly of sodium dodecylsulfate and dodecyltrimethylammonium bromide mixed surfactants with dyes in aqueous mixtures

et al. 2019

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“…However, cationic surfactants produce higher toxicity. Among cationic surfactants, CTAB (cetyl trimethyl ammonium bromide) and DDAB (dimethyl dioctadecyl ammonium bromide) are commonly reported for fabrication of cationic lipid nanoparticles for various applications [ 99 ]. Silva et al evidenced CTAB as highly toxic in comparison with DDAB, used at the same concentration [ 100 ].…”

Section: Encapsulation Of Ergot Alkaloids For Ocular Administratiomentioning

confidence: 99%

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

et al. 2020

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Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma.

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“…Indeed, it has been documented that non-ionic surfactants are less toxic, than ionic surfactants [3,15], while cationic surfactants have been reported to produce higher toxicity, as a result of their higher interaction with cell membranes [3,14,16]. Among cationic surfactants, CTAB (cetyltrimethylammonium bromide) and DDAB (dimethyldioctadecylammonium bromide) have been used in various industrial processes (e.g., as biocides and antiseptic agents [17]), and in the production of drug-loaded nanoparticles for various applications [4,[18][19][20][21][22][23]. While CTAB has a single chain and a single positive charged head-group, DDAB on the other hand is a double chain cationic lipid showing higher lipophilicity [24].…”

Section: Introductionmentioning

confidence: 99%

Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLNs)

et al. 2019

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The surface properties of nanoparticles have decisive influence on their interaction with biological barriers (i.e., living cells), being the concentration and type of surfactant factors to have into account. As a result of different molecular structure, charge, and degree of lipophilicity, different surfactants may interact differently with the cell membrane exhibiting different degrees of cytotoxicity. In this work, the cytotoxicity of two cationic solid lipid nanoparticles (SLNs), differing in the cationic lipids used as surfactants CTAB (cetyltrimethylammonium bromide) or DDAB (dimethyldioctadecylammonium bromide), referred as CTAB-SLNs and DDAB-SLNs, respectively, was assessed against five different human cell lines (Caco-2, HepG2, MCF-7, SV-80, and Y-79). Results showed that the cationic lipids used in SLN production highly influenced the cytotoxic profile of the particles, with CTAB-SLNs being highly cytotoxic even at low concentrations (IC50 < 10 µg/mL, expressed as CTAB amount). DDAB-SLNs produced much lower cytotoxicity, even at longer exposure time (IC50 from 284.06 ± 17.01 µg/mL (SV-80) to 869.88 ± 62.45 µg/mL (MCF-7), at 48 h). To the best of our knowledge, this is the first report that compares the cytotoxic profile of CTAB-SLNs and DDAB-SLNs based on the concentration and time of exposure, using different cell lines. In conclusion, the choice of the right surfactant for biological applications influences the biocompatibility of the nanoparticles. Regardless the type of drug delivery system, not only the cytotoxicity of the drug-loaded nanoparticles should be assessed, but also the blank (non-loaded) nanoparticles as their surface properties play a decisive role both in vitro and in vivo.

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Study of interaction between cationic surfactant (CTAB) and paracetamol by electrical conductivity, tensiometric and spectroscopic methods

Cited by 37 publications

References 40 publications

Self-assembly of sodium dodecylsulfate and dodecyltrimethylammonium bromide mixed surfactants with dyes in aqueous mixtures

Self-assembly of sodium dodecylsulfate and dodecyltrimethylammonium bromide mixed surfactants with dyes in aqueous mixtures

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

Soft Cationic Nanoparticles for Drug Delivery: Production and Cytotoxicity of Solid Lipid Nanoparticles (SLNs)

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