Study of In Vitro and In Vivo Carbamazepine Release from Coarse and Nanometric Pharmaceutical Emulsions Obtained via Ultra-High-Pressure Homogenization

Echeverri, Juan D.; Alhajj, Maria J.; Montero, Nicolle; Yarce, Cristhian J.; Barrera-Ocampo, Álvaro; Salamanca, Constaín H.

doi:10.3390/ph13040053

Cited by 7 publications

(3 citation statements)

References 51 publications

(55 reference statements)

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“…One of commonly used variants of this method is a two-stage technology that combines precipitation with high-pressure homogenization. This method has been successfully used to form nanocrystals of drugs such as Albendazole [31], Carbamazepine [32], and Amphotherin B [33]. Nanosuspensions of Aprepitant and Ibuprofen have also been produced [34] using a combination of pretreatment methods, including precipitation and ball milling followed by high-pressure homogenization, resulting in nanoparticles of about 100 nm in size.…”

Section: High-pressure Homogenizationmentioning

confidence: 99%

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Shabatina,

Gromova,

Vernaya

et al. 2024

Pharmaceuticals

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The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations of a bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations. It is known that many drug substances that are currently in development are poorly soluble in water, so they have insufficient bioavailability. Converting them into nanoforms will increase their rate of dissolution, and the increased saturation solubility of drug nanocrystals also makes a significant contribution to their high therapeutic efficiency. Some physical and chemical methods can contribute to the formation of both pure drug nanoparticles and their ligand or of polymer-covered nanoforms, which are characterized by higher stability. This review describes the most commonly used methods for the preparation of nanoforms (nanoparticles) of different medicinal substances, paying close attention to modern supercritical and cryogenic technologies and the advantages and disadvantages of the described methods and techniques; moreover, the improvements in the physico-chemical and biomedical properties of the obtained medicinal nanoforms are also discussed.

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Section: High-pressure Homogenizationmentioning

confidence: 99%

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Shabatina,

Gromova,

Vernaya

et al. 2024

Pharmaceuticals

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“…Echeverri et al synthesized nanoemulsions loaded with carbamazepine drug via ultra-highpressure homogenization [43]. Experiments on rats indicated that the nanoemulsions significantly improved the drug absorption time in blood, from 12 hours for coarse emulsion to 45 minutes for nanoemulsion formulations.…”

Section: Rhamnolipid-coatedmentioning

confidence: 99%

Review: emulsion techniques for producing polymer based drug delivery systems

Nguyen

Hoàng

2023

Vietnam J. Sci. Technol.

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Emulsification method is one of the popular methods for producing materials used inbiosensing, bioimaging and others, especially, drug delivery polymer systems in microsize andnanosize. The concrete techniques related to this method are emulsification, self-emulsification,in a combination with solvent evaporation process, homogenization, or ultranosication. Thestructure of emulsion formulation consists of two phases: an internal phase and an externalphase. Based on the structure and nature of the phases, emulsions can be classified into differenttypes such as two-phase systems (oil in water emulsion (O/W) or water in oil emulsion (W/O))or three-phase systems (water in oil in water triple emulsion (W/O/W) or oil in water in oil tripleemulsion (O/W/O)). The droplet sizes in micro-emulsion systems are often higher than 1 mwhile those in nano-emulsions or mini-emulsions are in the range of 100-500 nm. Some specialnano-emulsion systems can contain droplets with a size of few nanometers. Factors includingsolvents, oil/water phase ratio, droplet oil size, composition ratio, nature of raw materials,emulsifiers, etc. can affect the morphology, properties, and size of the obtained products. Thispaper reviews emulsion techniques which have been applied for producing polymeric drugdelivery systems. The components, properties, characteristics, encapsulation efficiency as wellas drug release rate, water solubility, toxicity and administration efficacy of drug emulsionformulations will be mentioned. Advantages and limitations of emulsion techniques are alsodiscussed.

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“…The use of ALA for the preparation of a nanoemulsion was investigated by Kuznetcova et al, who obtained a stable formulation of about 100 nm with a negative surface charge [11]. Moreover, sacha inchi oil was exploited by Echeverri et al to prepare a nanoemulsion with good stability over time, unlike the coarse emulsion [46].…”

Section: Nanoemulsion Systemsmentioning

confidence: 99%

Combination of Nanodelivery Systems and Constituents Derived from Novel Foods: A Comprehensive Review

Truzzi,

Bertelli,

Bilia

et al. 2023

Pharmaceutics

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Novel Food is a new category of food, regulated by the European Union Directive No. 2015/2283. This latter norm defines a food as “Novel” if it was not used “for human consumption to a significant degree within the Union before the date of entry into force of that regulation, namely 15 May 1997”. Recently, Novel Foods have received increased interest from researchers worldwide. In this sense, the key areas of interest are the discovery of new benefits for human health and the exploitation of these novel sources of materials in new fields of application. An emerging area in the pharmaceutical and medicinal fields is nanotechnology, which deals with the development of new delivery systems at a nanometric scale. In this context, this review aims to summarize the recent advances on the design and characterization of nanodelivery systems based on materials belonging to the Novel Food list, as well as on nanoceutical products formulated for delivering compounds derived from Novel Foods. Additionally, the safety hazard of using nanoparticles in food products, i.e., food supplements, has been discussed in view of the current European regulation, which considers nanomaterials as Novel Foods.

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Study of In Vitro and In Vivo Carbamazepine Release from Coarse and Nanometric Pharmaceutical Emulsions Obtained via Ultra-High-Pressure Homogenization

Cited by 7 publications

References 51 publications

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Review: emulsion techniques for producing polymer based drug delivery systems

Combination of Nanodelivery Systems and Constituents Derived from Novel Foods: A Comprehensive Review

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