Study of immunoglobulins in pleura and pleural effusions.

Telvi, Louise; Jaubert, Françis; Eyquem, A; Andreux, J.‐P.; Labrousse, F; Chrétien, J

doi:10.1136/thx.34.3.389

Cited by 18 publications

(10 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If not, a negative value for a purely blood-borne immunoglobulin may be obtained. From the present data as well as from those of other studies (Ballow and Mendelson, 1980;Telvi et al, 1979) it can indeed be deduced that immunoglobulins penetrate tissue barriers more slowly than the above-mentioned markers (HSA, transferrin), probably due to their higher molecular weight.…”

Section: Discussionsupporting

confidence: 83%

A contribution to the immunopathology of vernal keratoconjunctivitis

et al. 1982

View full text Add to dashboard Cite

The tear fluid contains proteins which are synthesized locally in the conjuncfiva and lacrimal glands, and others, which reach the tear fluid from the blood circulation. It is generally accepted that serum albumin (HSA) belongs to the latter group of tear proteins. Consequently, the ratio between tile levels of HSA in the tear fluid and in the blood serum can be used as a parameter for the degree of vascular leakage. All blood-borue tear proteins will show concentration ratios in tears and blood serum similar to HSA, provided that they pass through the blood-tear barrier at the same flow rate as HSA. This principle may be used to determine whether a certain tear protein is blood-borne or locally synthesized. An additional method to determine the source of tear proteins is supposed, and is based on the assumption that blood-borne proteins will occur in tears from both eyes at a concentration ratio similar to that of HSA, whereas the concentration ratios of locally synthesized proteins will not be related to the HSA-levels in the tears of the two eyes. This method is independent of the rate of diffusion through tissue barriers.In the present study these methods have given coordinating and supplementary information. The IgG and IgM contents of tears from healthy eyes and from patients with vernal keratoconjunctivitis (VC) were shown to be essentially blood-borne. In tears from VC-pafients as well as from healthy controls, IgE was usually found to be a product of local synthesis. In tears from healthy eyes, IgA was almost entirely synthesized locally, but a significant part of the IgA in tears from inflamed eyes was blood-borne.The geometrical mean (GM) of blood levels of IgE for VC-patients was not increased in relation to the GM for healthy controls of the same age groups. In contrast, the GM for IgE in tears from VC-patients (27.5 I.U./ml) was higher than the GM + 2 SD for the healthy controls (4.1 I.U./ml) and also than the highest level of IgE observed in tears from healthy eyes (6.6 I.U./ml). The tear-levels of IgE for VC-patients were strikingly dynamic and in some patients a hundred-fold increase or decrease was observed in the course of a relatively short time period. In contrast, alterations of blood-levels of IgE and of tear levels of IgA were relatively moderate. These results indicate a marked association between VC and an increased IgE-content of tears derived from local immunocytes. However, in some patients apparently suffering from typical VC, normal IgE-levels were consistently found in tears from both eyes during a number of relapses or aggravations of the disease. These results may indicate that more than one etiopathogenesis may lead to the clinical condition known as VC. A hitherto unexplained feature of VC is the pronounced lacrimation. We have shown that the concentration of the essential tearproteins is not decreased in VC. Lacrimation is therefore associated with accelerated protein synthesis of the secretory system.

show abstract

Section: Discussionsupporting

confidence: 83%

A contribution to the immunopathology of vernal keratoconjunctivitis

et al. 1982

View full text Add to dashboard Cite

show abstract

“…Using similar tracers, transmesothelial transport has also been shown to occur through intracellular junctions and stomata 25,36,38,61–63 rather than occurring by passive diffusion. However, others have found no evidence to support this hypothesis 38,64,65 …”

Section: Mesothelial Transportmentioning

confidence: 99%

“…However, others have found no evidence to support this hypothesis. 38,64,65 Studies of the enzymes associated with flattened resting mesothelial cells and cuboidal 'activated' mesothelial cells have demonstrated a difference in the enzymatic profile of each mesothelial cell type. 62,[66][67][68][69][70][71][72] The studies indicated that resting mesothelium is mainly concerned with membrane transport, whereas cuboidal mesothelial cells have a wider spectrum of functional activities.…”

Section: Mesothelial Transportmentioning

confidence: 99%

Mesothelial cells: Their structure, function and role in serosal repair

2002

View full text Add to dashboard Cite

Mesothelial cells: Their structure, function and role in serosal repair MUTSAERS SE. Respirology 2002; 7: 171-191 The mesothelium is composed of an extensive monolayer of specialized cells (mesothelial cells) that line the body's serous cavities and internal organs. Traditionally, this layer was thought to be a simple tissue with the sole function of providing a slippery, non-adhesive and protective surface to facilitate intracoelomic movement. However, with the gradual accumulation of information about serosal tissues over the years, the mesothelium is now recognized as a dynamic cellular membrane with many important functions. These include transport and movement of fluid and particulate matter across the serosal cavities, leucocyte migration in response to inflammatory mediators, synthesis of pro-inflammatory cytokines, growth factors and extracellular matrix proteins to aid in serosal repair, release of factors to promote both the deposition and clearance of fibrin, and antigen presentation. Furthermore, the secretion of molecules, such as glycosaminoglycans and lubricants, not only protects tissues from abrasion, but also from infection and possibly tumour dissemination. Mesothelium is also unlike other epithelial-like surfaces because healing appears diffusely across the denuded surface, whereas in true epithelia, healing occurs solely at the wound edges as sheets of cells. Although controversial, recent studies have begun to shed light on the mechanisms involved in mesothelial regeneration. In the present review, the current understanding of the structure and function of the mesothelium and the biology of mesothelial cells is discussed, together with recent insights into the mechanisms regulating its repair.

show abstract

“…In contrast, the FeLV antigen titer in the ascites was 1.45-fold higher on average than that in the serum in the antigenpositive cats. It has been reported that the ratio of exudates/ serum proteins was inversely related to the molecular weight in humans [11]. The FeLV antigen test performed in this study detects p27 viral core antigen with a molecular weight of 27 k Dalton [6].…”

mentioning

confidence: 69%

Detection of Feline Coronavirus Antibody, Feline Immunodeficiency Virus Antibody, and Feline Leukemia Virus Antigen in Ascites from Cats with Effusive Feline Infectious Peritonitis

Soma

Ishii²

2004

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. To investigate the usefulness of ascites as a material for viral tests in cats with effusive feline infectious peritonitis (FIP), we attempted to detect anti-feline coronavirus antibody, anti-feline immunodeficiency virus antibody, and feline leukemia virus antigen in ascites from 88 cats clinically suspected with effusive FIP. In each of these three viral tests, all cats positive for serum an tibody/antigen were also positive for ascitic antibody/antigen, while cats negative for serum antibody/antigen were also negative for ascitic antibody/ antigen. This finding indicates that ascites is useful for these viral tests. KEY WORDS: ascites, FIP, viral test.

show abstract

Study of immunoglobulins in pleura and pleural effusions.

Cited by 18 publications

References 7 publications

A contribution to the immunopathology of vernal keratoconjunctivitis

A contribution to the immunopathology of vernal keratoconjunctivitis

Mesothelial cells: Their structure, function and role in serosal repair

Detection of Feline Coronavirus Antibody, Feline Immunodeficiency Virus Antibody, and Feline Leukemia Virus Antigen in Ascites from Cats with Effusive Feline Infectious Peritonitis

Contact Info

Product

Resources

About