Study of<i>CXCL9-11</i>gene polymorphisms in liver fibrosis among patients with chronic hepatitis C

Magri, Mariana Cavalheiro; Alvarez, Maria Stella Montanha; Iogi, Anny Ayumi; Alves, Grayce Mendes; Manchiero, Caroline; Dantas, Bianca Peixoto; Prata, Thamiris Vaz Gago; Nunes, Arielle Karen da Silva; Tengan, Fátima Mitiko

doi:10.1093/femspd/ftab007

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…It is an evolutionarily conserved dynein-like large GTPase, which can significantly inhibit a variety of RNA viruses and also has a certain inhibitory effect on other viruses 39 . CXCL10, also known as IFN-γ-inducible protein 10, is significantly dysregulated during HCV infection, and the interaction between CXCL10 and its receptor CXCR3 can regulate the occurrence and development of viral hepatitis 40 , 41 . This means that CXCL10 may be involved in the antiviral response of patients with hepatitis C. Our results have also shown that CXCL10 exerted an inhibitory effect on HCV replication.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA UCA1 regulates HCV replication and antiviral response via miR-145-5p/SOCS7/IFN pathway

Zeng¹,

Li²,

Gao³

et al. 2021

Int. J. Biol. Sci.

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Hepatitis C virus (HCV) infection involves a variety of viral and host factors, which leads to the dysregulation of number of relevant genes including long noncoding RNAs (LncRNAs). LncRNA urothelial carcinoma-associated 1 (UCA1) has been reported to be upregulated in HCV-infected individuals. In a bid to elucidate on the contribution of UCA1 on HCV replication, we infected Huh7.5 cells with cell culture-derived HCV and found that UCA1 expression was elevated in time-and dose-dependent manners. Functionally, UCA1 knockdown by siRNA upregulated interferon (IFN) responses, thereby increasing the expression of interferon-stimulating genes (ISGs), and subsequently suppressing HCV replication. Bioinformatics analysis and experimental results indicated that, functioning as competitive endogenous RNA, UCA1 could sponge microRNA (miR)-145-5p, which targeted suppressor of cytokine signaling 7 (SOCS7) mRNA and subsequently mediated SOCS7 silencing. Moreover, SOCS7 protein exerted an inhibitory effect on IFN responses, thereby facilitating HCV replication. Taken together, at first, our findings demonstrate that UCA1 can counteract the expression of miR-145-5p, thereby upregulating the level of SOCS7, and in turn leading to the suppression of antiviral response in Huh7.5 cells.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA UCA1 regulates HCV replication and antiviral response via miR-145-5p/SOCS7/IFN pathway

Zeng¹,

Li²,

Gao³

et al. 2021

Int. J. Biol. Sci.

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“…Previous studies have reported associations between IP-10/CXCL10 levels and cirrhosis, liver function, and hepatitis activity. For instance, IP-10/CXCL10 has been found to play a key role in the development of in ammation and brosis in chronic hepatitis C, with elevated blood levels observed in patients with severe brosis [33][34][35][36][37]. In patients with hepatitis C, higher levels of IP-10/CXCL10 were observed in those with Child-Pugh B cirrhosis compared to those with Child-Pugh A cirrhosis [37].…”

Section: Numerous Recent Studies Have Investigated the Correlation Be...mentioning

confidence: 99%

Elevated serum IP-10/CXCL10 levels are associated with sarcopenia development, a prognostic factor, in patients with primary hepatocellular carcinoma

Takada,

Yamashita,

Osawa

et al. 2023

Preprint

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Sarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). However, the mechanism underlying sarcopenia development in patients with HCC remains unclear. The chemokine interferon-gamma-induced protein 10/C-X-C motif chemokine ligand 10 (IP-10/CXCL10) has emerged as one of the mechanisms in previous studies. Therefore, we aimed to elucidate the significance of sarcopenia, and investigate the association between serum IP-10/CXCL10 levels and sarcopenia development. This retrospective study included 738 patients with primary HCC, and among these patients, serum IP-10/CXCL10 levels were measured both at baseline and after 1–3 years in a subset of 135 patients. Among patients with primary HCC, those with sarcopenia at baseline had a poorer prognosis than those without, and patients with sarcopenia at 1, 3, and 5 years after the first occurrence of HCC had a poorer prognosis. Furthermore, serum IP-10/CXCL10 ratios were found to be higher in patients with sarcopenia at baseline and those who developed sarcopenia during the observation period than in those without sarcopenia (p = 0.0016). This study revealed that the significance of sarcopenia as a prognostic factor in patients with HCC, and the changes in serum IP-10/CXCL10 levels appear to be associated with the development of sarcopenia following the first occurrence of HCC.

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Study ofCXCL9-11gene polymorphisms in liver fibrosis among patients with chronic hepatitis C

Cited by 2 publications

References 44 publications

Long noncoding RNA UCA1 regulates HCV replication and antiviral response via miR-145-5p/SOCS7/IFN pathway

Long noncoding RNA UCA1 regulates HCV replication and antiviral response via miR-145-5p/SOCS7/IFN pathway

Elevated serum IP-10/CXCL10 levels are associated with sarcopenia development, a prognostic factor, in patients with primary hepatocellular carcinoma

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