Study of Hyponatremia in Cirrhosis of Liver and It’s Prognostic Value

Abstract

Objective: Study conducted to know the prevalence of hyponatremia in cirrhosis and to evaluate the association between hyponatremia and complications in cirrhosis and its prognostic value. Methods: Patients were selected based on clinical examination, biochemical tests and ultrasound abdomen. All the patients were examined at the time of admission in the hospital and their serum sodium levels were checked and the patients were followed during their stay in the hospital. The severity of cirrhosis was assessed according to Child-Pugh score. MELD score and MELD-Na score were also calculated at the time of admission. Results: Study done on 100 cirrhotic patients, most common etiology for cirrhosis in this study was alcohol. 53% had hyponatremia(<136meq/l). Complications of cirrhosis were more in hyponatremia patients. Among the complications portal hypertension (57%), hepatic encephalopathy(89.28%), hepatorenal syndrome (42.8%) among hyponatremia cirrhotic patients are statistically significant(p<0.05). child pughturcot score, MELD, MELD-Na score are also high in hyponatremia. Mortality also seen more in severe hyponatremia. Conclusion: Dilutional hyponatremia is frequent in cirrhotic patients and associated with severe complications of liver cirrhosis like hepatic encephalopathy, hepatorenal syndrome. Hyponatremia is also associated with high morbidity and mortality in cirrhotic patients.

Portal Hemodynamics In Hyponatremic Egyptian Cirrhotic Patients

“…In the current study, hyponatremic had a statistically significant difference when compared with non-hyponatremic group in the presence of splenomegaly and ascites and high statistically significant difference as regard collaterals. These results were similar to those of Angeli et al, Kim et al, and Maruyama et al, [10,11,14] and as regard ascites and collaterals but was not as regard splenomegaly as Maruyama et al, [9,14] stated no relation between hyponatermia and splenic size, also, Reddy et al, [12] reported significant difference only in refractory ascites. Some authors specify that hyponatremia denotes parenchymal affection and others postulate that it denotes mesenchymal affection with close relation to portal hemodynamics.…”