Study of human leukocyte antigen class I phenotypes in Moroccan patients with nasopharyngeal carcinoma

Dardari, Rkia; Khyatti, Meriem; Jouhadi, H.; Benider, Abdellatif; Ettayebi, Hanae; Kahlain, A; Mansouri, Aziz; Gueddari, B.K. El; Benslimane, A.

doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1177>3.0.co;2-9

Cited by 35 publications

(20 citation statements)

References 19 publications

(1 reference statement)

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“…Subsequent association studies among the Chinese have elaborated further HLA association with NPC, notably, an increased risk associated with B58, and a decreased risk for A11 (Chan et al, 1983;Hildesheim et al, 2002;Lu et al, 2003). Among other ethnic groups, however, the pattern of association with HLA alleles is rather different, with A2 appearing protective in Caucasians (Burt et al, 1994), and A11 not conferring protection among north Africans (Betuel et al, 1975;Herait et al, 1983;Dardari et al, 2001). The present study was undertaken to examine further the HLA A and B associations among southern Chinese.…”

supporting

confidence: 78%

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Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese

Day

et al. 2005

Br J Cancer

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We typed 247 cases of nasopharyngeal carcinoma (NPC), a disease predominantly of the southern Chinese, and 274 controls from the Chao Shan region of China's Guangdong province for HLA A and B. Besides confirming the established associations with A2, A33, B46 and B58 (positive associations) and A11 (negative association), the results demonstrated a number of rarer alleles with strong negative association with NPC. Our data, combined with those from the previous studies in Southern Chinese, displayed the protective effects for A31 (odds ratio (OR) ¼ 0.0; 95% confidence interval (CI) ¼ 0 -0.11), B13 (OR ¼ 0.50; 95% CI ¼ 0.35 -0.69), B27 (OR ¼ 0.49; 95% CI ¼ 0.25 -0.92), B39 (OR ¼ 0.18; 95% CI ¼ 0.06 -0.48) and B55 (OR ¼ 0.32; 95% CI ¼ 0.14 -0.68), the ORs comparing individuals with or without each allele. Other ethnic groups do not display such large HLA-associated variation in NPC risk. We show that a linked NPC gene with dominant mode of action could not generate such large protective effects. The results provide strong supporting evidence for the existence of a southern Chinese specific, recessive NPC gene closely linked to the HLA region as a major determinant of the Chinese risk for the disease.

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supporting

confidence: 78%

“…Among Caucasians, A31, B13, and B27 were more common in cases than in controls (Moore et al, 1983). In north Africans from Algeria (Herait et al, 1983) and Morocco (Dardari et al, 2001), neither B13 nor B27 conferred protection (no results were given for A31, B39, or B55).…”

Section: Resultsmentioning

confidence: 99%

Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese

Day

et al. 2005

Br J Cancer

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“…Serological analyses reported positive associations between NPC and HLA: these included increased frequency of HLA-B5 in Algerians (38.2% vs 24.4%) [22], HLA-B13 in Tunisians (15.5% vs 4%) [23] and HLA-B18 in Moroccans, of which only the last was significant after correction for number of specificities tested (relative risk = 4.14) [24]. In 1983, Heirat P et al .…”

Section: Introductionmentioning

confidence: 99%

Associations between HLA Class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians

Ghandri

Piancatelli

et al. 2007

J Transl Med

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The high prevalence of nasopharyngeal cancer (NPC) in Southern Asia and Mediterranean Northern Africa suggests genetic predisposition among other factors. While Human Leukocyte Antigen (HLA) haplotypes have been conclusively associated with NPC predisposition in Asians, Northern African Maghrebians have been less intensely studied. However, low resolution serological methods identified weak positive associations with HLA-B5, B13 and B18 and a negative with HLA-B14. Using sequence based typing (SBT), we performed a direct comparison of HLA class I frequencies in a cohort of 136 Tunisian patients with NPC matched for gender, age and geographical residence to 148 normal Tunisians. The bimodal age distribution of NPC in Maghrebians was also taken into account. HLA frequencies in normal Tunisians were also compared with those of Northern Moroccan Berbers (ME) to evaluate whether the Tunisian population in this study could be considered representative of other Maghrebian populations. HLA-B14 and -Cw08 were negatively associated with NPC (odd ratio = 0.09 and 0.18 respectively, Fisher p 2 -value = 0.0001 and = 0.003). Moreover, positive associations were observed for HLA-B-18, -B51 (split of -B5) and -B57 (p 2 -value < 0.025 in all) confirming previous findings in Maghrebs. The HLA-B14/Cw*08 haplotype frequency (HF) was 0.007 in NPC patients compared to 0.057 in both Tunisian (OR = 0.12; p 2 -value = 0.001) and Moroccan controls. This study confirms several previous associations noted by serologic typing between HLA class I alleles and the prevalence of NPC in Maghrebians populations. In addition, we identified a putative haplotype rare in Tunisian patients with NPC that may serve as a genetic marker for further susceptibility studies.

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“…12 13 Case-control studies have established associations between specific HLA molecules and NPC in several populations including Asians, whites, and North Africans. [14][15][16] In addition to the HLA, some non-HLA loci, including the heat shock protein 70-2 (HSP70-2), 17 cyclin D1 (CCND1), 18 glutathione S-transferase M1 (GSTM1), 19 and CYP2E1 genes 4 have also shown associations with susceptibility to NPC. Based on the fact that the disease susceptibility to NPC is determined at different functional levels, such as metabolism of carcinogenic constituents, tumour antigen presentation, cell cycle regulation, and antigenic peptide chaperones, we hypothesised that an unknown number of other unidentified genes are likely to modify the susceptibility to NPC.…”

mentioning

confidence: 99%

Association of PLUNC gene polymorphisms with susceptibility to nasopharyngeal carcinoma in a Chinese population

2005

Journal of Medical Genetics

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Study of human leukocyte antigen class I phenotypes in Moroccan patients with nasopharyngeal carcinoma

Cited by 35 publications

References 19 publications

Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese

Further evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese

Associations between HLA Class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians

Association of PLUNC gene polymorphisms with susceptibility to nasopharyngeal carcinoma in a Chinese population

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