Study of HLA antigens of the Martinican population

Monplaisir, N; Valette, Ignez; Lepage, V.; Dijon, Veronique; Lavocat, E.; Ribal, C.; Raffoux, C

doi:10.1111/j.1399-0039.1985.tb00928.x

Cited by 18 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The objective of this study is to describe the characteristics of SAH and to estimate its incidence and severity in Martinique, a small French overseas island with a population of mostly African descent [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Mortality of Spontaneous Subarachnoid Hemorrhage in Martinique

et al. 2016

View full text Add to dashboard Cite

BackgroundIncidence of spontaneous subarachnoid hemorrhages (SAH) varies wildly across the world and seems to be low in Central and South America (4.2 per 100 000 person-years; CI 95%; 3.1–5.7). The objective of our study was to describe the characteristics of SAH and to estimate its incidence and severity in Martinique, a small French island located in the Caribbean Sea.MethodsDue to its insular nature and small captive population, Martinique is ideal for the setting up of population-based epidemiological studies with good exhaustiveness. Our study, spanning a 7 year period (2007–2013), consisted of retrospective case ascertainment with multiple overlapping methods. Crude incidence and 30 day case-fatality rates for SAH among the Martinican population were computed for the study period. Incidence and disease severity was also analyzed according to age, gender and aneurysm presence. World age-standardized incidence rates were also calculated.ResultsA total of 121 patients had a SAH during the study period, with a higher frequency of female cases (71.1% versus 28.9%, p<0.001). Patient mean age was 57.1 years (median = 55 [46–66]). An aneurysmal origin was found in 96 SAH cases (79.3%). Crude annual incidence was 4.36 per 100 000 person-years (CI 95% 2.30–6.42). World age-standardized incidence was 3.29 per 100 000 person-years (CI 95% 1.74–4.84). During the 30 days following SAH diagnosis, 29 patients died (case fatality rate: 24% (CI 95% 16.4–31.6)).ConclusionsThe incidence of spontaneous subarachnoid hemorrhage in Martinique is much lower than in other parts of the world and similar to countries in Central and South America. These results are possibly related to environmental factors and most particularly to a low rate of smoking in the Martinican population. Thirty-day case-fatality rate is similar to what is observed in developed countries.

show abstract

Section: Introductionmentioning

confidence: 99%

Incidence and Mortality of Spontaneous Subarachnoid Hemorrhage in Martinique

et al. 2016

View full text Add to dashboard Cite

show abstract

“…One may speculate that there exists a cross-reaction between streptococcal antigens and HLA antigens or that the B35 or DR1 antigen are linked with an Ir gene predisposing to abnormal anti-streptococcal response. Additionally, one should note that the Bw42 antigen and to a lesser degree the B14 antigen, found at decreased frequency in rheumatic fever are relatively specific of the Black population (Monplaisir et al 1985).…”

Section: Discussionmentioning

confidence: 99%

“…We have been able to collect blood from 88 patients with rheumatic fever in Martinique (a French island with 300,000 inhabitants) where the disease is still highly prevalent (Chalon et al 1986). We report here the results of a study of class I and class I1 HLA antigens in such patients, compared to a control population of identical origin, already studied by two of us (Monplaisir et al 1985).…”

mentioning

confidence: 95%

HLA antigens in 88 cases of rheumatic fever observed in Martinique

1986

Self Cite

View full text Add to dashboard Cite

HLA‐A, B, C and DR antigens were studied in 88 patients from Martinique. A modest but significant reduction of B14 and Bw42 antigens was noted as well as an increase in B35 (p < 0.05) and DR1 antigens (corrected p < 0.05), two antigens known to be in linkage disequilibrium. These data, which corroborate a previous study for B35, suggest that the unusual antistreptococcal response mounted by rheumatic fever patients is under HLA control.

show abstract

“…Martinique is one of the most highly developed islands in the Caribbean basin, classified high (41st) in terms of global human development at the world level. The population, of 355 094 inhabitants (January 1 st 2020), is predominantly of Afro-Caribbean origin ( 24 ). The University Hospital of Martinique is equipped with a technical platform in neurology, cardiology and hematology, and hosts the only expert medical center for amyloidosis management of the Caribbean region.…”

Section: Methodsmentioning

confidence: 99%

Cerebral Ischemic Events: An Overlooked Complication of Transthyretin Cardiac Amyloidosis in Afro-Caribbean Patients

et al. 2022

View full text Add to dashboard Cite

AimThe link between transthyretin cardiac amyloidosis (CATTR), and cerebral ischemic events (CIE) has only been hinted at till now, impeding progress in patient management. We seek to evaluate the frequency and characteristics of CIE in Afro-Caribbean patients followed for CATTR at our institution.MethodsIn this single-center retrospective observational study, Afro-Caribbean patients followed for CATTR between July 2005 and October 2019 were included. Occurrence of CIE was investigated, and their cardioembolic origin determined. Analysis of patient characteristics was conducted according to CIE and CATTR profiles.ResultsOverall, 120 CATTR patients were included: 17 wild-type ATTR (14.2%), 73 ATTR-V122I (60.8%), and 22 ATTR-I107V (18.3%). Thirty-six patients (30.0%) presented with CIE, including three transient ischemic attacks and 33 permanent ischemic strokes (75.8% with a cardioembolic pattern). CIE was concomitant with CATTR diagnosis in 16 (16/36: 44.4%) patients, while 14 patients (14/36: 38.9 %) experienced CIE over a median CATTR follow-up of 2.0 years (min-max range: 0.8–4.4 years). CATTR-CIE patients presented with atrial fibrillation (66.7%), left atrial enlargement (77.8%), a CHA2DS2-VASc ≥ 3 (97.2%) and a high anticoagulant intake (75.0%). Multivariate analysis retained only a high CHA2DS2-VASc score as an independent predictor of CIE risk (Hazard Ratio [95% CI]: 12.03 [1.62–89.24]).ConclusionConcomitant CIE, and CATTR diagnosis, potentially carries a worse prognosis. A CHA2DS2-VASc score ≥3 seems to be a strong and independent predictive factor of CIE in CATTR patients. Further studies are needed to assess the efficacy and timeliness of anticoagulation in CATTR patients, independently of atrial fibrillation.

show abstract

Study of HLA antigens of the Martinican population

Cited by 18 publications

References 4 publications

Incidence and Mortality of Spontaneous Subarachnoid Hemorrhage in Martinique

Incidence and Mortality of Spontaneous Subarachnoid Hemorrhage in Martinique

HLA antigens in 88 cases of rheumatic fever observed in Martinique

Cerebral Ischemic Events: An Overlooked Complication of Transthyretin Cardiac Amyloidosis in Afro-Caribbean Patients

Contact Info

Product

Resources

About