Study of Hesperidine and Curkumin Nootropic Activity Under the Conditions of Focal Cerebral Ischemia

Abstract

The article presents the results of the study of the nootropic activity of hesperidin and curcumin in conditions of focal cerebral ischemia. Studies were conducted on Wistar male rats, which reproduced the focal ischemia of the right middle cerebral artery. Experimental compounds and the reference drug (Mexidol) are administered intragastrally at the next day after surgery at a dosage of 100 mg/kg for three days. Researched using memory and cognitive assessment models – the method of avoiding passive (passive avoidance reaction) and active (TEA) environments. The effect of these compounds on the level of formation of lactate, pyruvate, and the degree of necrosis was studied. Against the background of focal cerebral ischemia, hesperidin significantly improved the studied parameters, curcumin did not show a positive effect on all the studied parameters, and therefore inferior to the heotropic activity on nootropic activity. The results of experimental data suggest the possibility of further in-depth study of hesperidin for cerebroprotective and nootropic activity.