2020
DOI: 10.19163/1994-9480-2020-3(75)-107-111
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Study of Hesperidine and Curkumin Nootropic Activity Under the Conditions of Focal Cerebral Ischemia

Abstract: The article presents the results of the study of the nootropic activity of hesperidin and curcumin in conditions of focal cerebral ischemia. Studies were conducted on Wistar male rats, which reproduced the focal ischemia of the right middle cerebral artery. Experimental compounds and the reference drug (Mexidol) are administered intragastrally at the next day after surgery at a dosage of 100 mg/kg for three days. Researched using memory and cognitive assessment models – the method of avoiding passive (passive … Show more

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