Study of hepatitis C virus infection in 213 Hungarian patients with Sjögren's syndrome

Szodoray, Péter; Csepregi, A.; Héjjas, M; Horányi, Margit; Zeher, Margit

doi:10.1007/s002960100125

Cited by 10 publications

(5 citation statements)

References 15 publications

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“…The cause of SS is unknown, but a viral etiology has been suggested 32,45 . Recently, many authors have reported a relationship between SS and HCV 10–34 since the earliest report in 1991 by Ferri et al 10 . The reported frequency of anti‐HCV antibodies in SS patients has varied from 0 to 40%, as shown in Table 4, while the previous frequency of SS found in patients with HCV infection has varied from 9.5 to 57%, as shown in Table 5.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical symptoms of SS involve glandular and extraglandular manifestations 7–9 . Many studies have suggested that there is a relationship between SS and HCV 10–34 . Recently, we reported the high prevalence of symptoms including dry mouth and autoantibodies (antinuclear antibody, rheumatoid factor, anti‐SS‐A, and SS‐B antibodies), and oral lichen planus (OLP) in the inhabitants of a hyperendemic area of HCV infection 35 .…”

Section: Introductionmentioning

confidence: 99%

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Incidence of Sjögren's syndrome in Japanese patients with hepatitis C virus infection

Nagao¹,

Hanada

Shishido³

et al. 2003

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence of Sjögren's syndrome in Japanese patients with hepatitis C virus infection

Nagao¹,

Hanada

Shishido³

et al. 2003

J of Gastro and Hepatol

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“…The mean time of follow-up between SS diagnosis and protocol inclusion was 5.6 years, ranging between 1 and 13 years. Some patients have been included in previous studies 6,14,20,24,25,27 . Salient features included in the protocol form were the following: 1) Gender 2) Age at diagnosis of SS, defined as the age when the patient fulfilled the current criteria for the classification 29 3) Age at diagnosis of chronic HCV infection, defined as the first serologic evidence of HCV antibodies 4) Age at inclusion in the protocol 5) Sicca symptomatology ( To minimize possible interobserver bias, the inclusion criteria and protocol variables were agreed upon by all participating physicians.…”

Section: Methodsmentioning

confidence: 99%

Sjögren Syndrome Associated With Hepatitis C Virus

et al. 2005

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To define the clinical and immunologic pattern of expression of Sjögren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCV-RNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58%) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65%), hypocomplementemia (51%), and cryoglobulinemia (50%). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23%) patients had positive anti-Ro/SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14%) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS. In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term "SS secondary to HCV" when these patients fulfill the 2002 classification criteria for SS.

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“…Cryoglobulinemia can be considered a highly relevant immunoserological abnormality, the emergence of which in the follow-up period of pSS significantly impairs survival ratios and increases mortality risk. In our previous reports, we concluded that cryoglobulinemia may play a more important role in the extraglandular features observed in SS associated with hepatitis C virus (HCV) than it does in pSS alone, although these manifestations also might be related to either the underlying SS or the HCV infection itself [25, 26]. Interestingly, the mortality of the whole patient population was comparable to that of normal Hungarian population, demonstrating the adequacy of care and a relatively favourable course of the disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical Course, Prognosis, and Cause of Death in Primary Sjögren’s Syndrome

Horváth

Szántó

Papp

et al. 2014

Journal of Immunology Research

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The aim of this retrospective, single-centre study was to investigate the clinical and laboratory features and disease outcomes of 547 patients diagnosed with primary Sjögren's syndrome (pSS) between 1975 and 2010. The patients were followed up for 11.4 ± 6.2 years. We evaluated the clinical and laboratory features, and assessed their influence on the time of diagnosis, survival, and mortality ratios, and compared them within subgroups defined by gender, glandular and extraglandular manifestations (EGMs), associated diseases, and immunoserological abnormalities. The most frequent EGMs were polyarthritis, Raynaud's phenomenon, and vasculitis among our patients; the most common associated disease was thyroiditis. During the follow-up period, 51 patients died; the median survival time was 33.71 years. Our results revealed a negative effect of cryoglobulinemia on survival ratios; additionally, the presence of vasculitis and lymphoproliferative diseases at the time of diagnosis increased the risk of mortality. The development of vasculitis was the most powerful predictor of mortality. Mortality in the group of patients with extraglandular symptoms was two- to threefold higher than in the glandular group. Attention is drawn to the importance of close monitoring and targeted diagnostic approaches in those pSS subgroups with obviously increased mortality risk.

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Study of hepatitis C virus infection in 213 Hungarian patients with Sjögren's syndrome

Cited by 10 publications

References 15 publications

Incidence of Sjögren's syndrome in Japanese patients with hepatitis C virus infection

Incidence of Sjögren's syndrome in Japanese patients with hepatitis C virus infection

Sjögren Syndrome Associated With Hepatitis C Virus

Clinical Course, Prognosis, and Cause of Death in Primary Sjögren’s Syndrome

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