Study of Helicobacter pylori infection on lung using an animal model

Sosa, A.C. Arismendi; Ibáñez, Ángel Gabriel Salinas; Chaca, María Verónica Pérez; Penissi, Alicia Beatriz; Gómez, Nora; Vega, Alba Edith

doi:10.1016/j.micpath.2018.07.038

Cited by 13 publications

(16 citation statements)

References 43 publications

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“…Furthermore, studies involving animal models have shown that this increase occurred not only in serum but also in the lung tissue of infected mice, together with an increase in metalloproteinases and markers of endothelial dysfunction such as intracellular adhesion molecule-1 and intracellular adhesion molecule-5, involved in leukocyte adhesion and migration into the sub-endothelium. On the contrary, lungs from non-infected animals did not show these alterations [12]. This could reflect the genetic modification occurring in the lung as a result of gastric H. pylori infection.…”

Section: Discussionmentioning

confidence: 82%

“…Early epidemiologic studies on the relationship between H. pylori infection and respiratory diseases have been supported by the findings on animal models showing that the presence of the microorganisms in the gastric compartment could be associated with lung injury, as indicated by the increased expression of inflammatory mediators and markers of endothelial dysfunction [12]. Over time, a series of publications, mainly reporting the findings of epidemiologic studies, has focused on this issue and has provided controversial results.…”

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori and Respiratory Diseases: 2021 Update

et al. 2021

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Helicobacter pylori (H. pylori) is a Gram-negative bacterium involved in the development of gastritis, peptic ulcer disease, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue. Unexplained iron deficiency anemia, idiopathic thrombocytopenic purpura and vitamin B12 deficiency have also been related to H. pylori infection, whereas for other extra-gastric diseases, the debate is still open. In this review, we evaluate and discuss the potential involvement of H. pylori infection in the pathogenesis of several respiratory diseases. A MEDLINE search of all studies published in English from 1965 to 2021 was carried out. Controversial findings have been reported in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis, lung cancer, tuberculosis, cystic fibrosis, and sarcoidosis. Most of the available literature is concerned with case-control studies based on seroprevalence, with a small sample size and low consideration of confounders, which represents a potential issue. So far, there is no clear evidence of a causal association between H. pylori infection and respiratory diseases, and larger studies with appropriate epidemiological design are required.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and Respiratory Diseases: 2021 Update

et al. 2021

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“…Hence, intestinal probiotics should be tested for their ability to modulate cancer development. One example is the use of cisplatin, which does not significantly reduce tumors in mice unless administered with the human-derived bacteria L. acidophilus 35 , elucidating an improvement to an existing chemotherapy.…”

Section: Review Articlesmentioning

confidence: 99%

Mice, Models, Microbiota: How Can We More Accurately Reflect Human Disease?

Ladak

Philpott

2021

J Undergrad Life Sci

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With growing evidence that human disease is affected by the microbiota, many researchers have sought to modulate the microbiomes of mice to improve translational research. Altering their microbiomes, which are usually germ-free or specific pathogen-free, might allow mice to more accurately model human disease and hence produce more applicable findings. However, this has been difficult to apply to individual projects due to the disparity of explained methods and results. In this review, we first describe the immunological functions of the gut microbiota and the methods of altering mice microbiota, from transplantation route to age of transplantation to microbiota source. We then present an approach for how the gut microbiota might be considered when modelling human disease in mice. By organizing findings by type of disease - neurological, immunological, chronic inflammatory, and cancer - we propose that mouse models can be improved by considering the source of the microbiota, the presence or absence of certain microbial phyla, and by timing the transplantation during a physiologically relevant stage of development, such as the first five weeks of life.

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“…Concerning lung cancer, Arismendi Sosa et al explored the effect of H pylori gastric infection on the lung in a murine model; C57BL6 mice were infected by oral gavage and then sacrificed at several time points between 3 and 21 days postinfection. Histologic analysis reported recruitment of inflammatory cells and parenchymal cell degradation in the lungs of infected mice with an increased expression of inflammatory cytokines and markers of cell endothelium dysfunction . Also GonzÁlez et al , starting from the assumption that approximately 10% to 15% of lung cancers are not associated with exposure to tobacco, sustained the inflammatory hypothesis of lung cancer, with a possible role of H pylori infection…”

Section: Pulmonary Diseasesmentioning

confidence: 99%

Review:Helicobacter pyloriand extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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Study of Helicobacter pylori infection on lung using an animal model

Cited by 13 publications

References 43 publications

Helicobacter pylori and Respiratory Diseases: 2021 Update

Helicobacter pylori and Respiratory Diseases: 2021 Update

Mice, Models, Microbiota: How Can We More Accurately Reflect Human Disease?

Review:Helicobacter pyloriand extragastric diseases

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