Study of Hba1c Levels in Acute Coronary Syndrome

Y, Ramesh Naidu; Sharmila, Y; Y, Nischal; Srinivas, Vivek; Satyaprasad,

doi:10.14260/jemds/2015/1909

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…(11) Recent study by Ramesh naidu et al also found that patient with HbA1c <6.5 percent 16 out of 56 developed complication like left ventricular failure, cardiogenic shock, arrhythmias as compared to 16 of 20 patients with HbA1c >8.5 % which was statistically significant. (18) Left ventricular failure was most common complication followed by cardiogenic shock and Arrhythmia in patient having ACS in this study. In our study we also found cardiac failure as the most common complication followed by cardiogenic shock in HbA1c levels above >8.5% and positive correlation between HbA1c levels and complications like cardiac failure.…”

Section: Discussionmentioning

confidence: 54%

A study of the relation of HbA1c levels in acute coronary syndrome and its complications

Jacob¹

2019

jmscr

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Introduction: The risk of coronary artery disease (CAD) is higher in diabetic patients. In Indians, CAD occurs one decade earlier than the west. HbA1C is an easy marker of long term glucose regulation as it provides a good reflection of plasma glucose concentrations over 8 -12 weeks .Abnormal glucose metabolism is associated with increased mortality and complications following ACS. This study was conducted in ICU of Govt. Medical College, Ernakulam among patients admitted following ACS using HbA1C in blood and observing the complications for first week. Materials and Methods: 188 patients admitted with Acute Coronary Syndrome in Government Medical college, Ernakulam between January 2016 and December 2016, were evaluated clinically and with the investigatory facilities available at this institution. Their HbA1C levels were measured at the laboratory of Government Medical college Ernakulam. The clinical features and investigation results were noted. HbA1C levels in UNSTABLE ANGINA, NSTEMI, STEMI, and in complications like arrhythmias, cardiac failure, cardiogenic shock also were studied and the data analysed.

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Section: Discussionmentioning

confidence: 54%

A study of the relation of HbA1c levels in acute coronary syndrome and its complications

Jacob¹

2019

jmscr

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A Study on Glycaemic Status Impact in Acute Coronary Syndrome

Rajuri¹,

Priyanka²

2019

jemds

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BACKGROUND Coronary Artery Disease is the leading cause of death worldwide currently, resulting in around 7 million deaths per year and can rise by 40% around 2020. The prevalence of CAD and the incidence of ACS also are very high and occurs 5-10 years earlier among Indians. The overall cardiovascular mortality is predicted to have risen by 103% in men and 90% in women between 1985 and 2015. Hyperglycaemia is an independent risk factor for cardiovascular diseases. Therefore, we evaluated the effect of HbA1c values on clinical outcomes in diabetic and non-diabetic patients following acute coronary syndromes (ACS). METHODS The study was conducted in patients admitted with acute coronary syndromes in Department of Medicine in Chalmeda Anand Rao Institute of Medical Sciences from January 2017 to September 2018. Chi-square test was used wherever comparisons were needed between the two groups, or between two categories in the same group. A p value < 0.05 was considered significant. RESULTS SVD was seen in 100% of patients with HbA1c <5%. SVD and DVD were seen in 84.2 and 15.7% of patients with HbA1c 5.1-5.6%, respectively. SVD, DVD and TVD were seen in 57.65%, 34.6% and 7.6% of patients with HbA1c 5.7-6.4% respectively. SVD, DVD and TVD were seen in 50%, 15.3% and 34.6% of patients with HbA1c >6.5% respectively. In our study, RCA (42) was most frequently affected vessel followed by LAD (37) and LCX (20). CONCLUSIONS Higher HbA1c values were associated with more severe disease and more extensive involvement of coronary vessels in diabetics as well as pre-diabetics. RCA followed by LAD are common culprit vessel in diabetics.

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The effect of ticagrelor and clopidogrel on angiographic parameters according to diabetic status in patients with ST elevation myocardial infarction

et al. 2022

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Aim. We aimed to compare post-interventional angiographic outcomes of ticagrelor versus clopidogrel according to glycosylated hemoglobin (HbA1c) levels in patients with ST-elevation myocardial infarction.Material and methods. The study included a total of 532 patients, with 334 receiving ticagrelor (62,8%) and 198 clopidogrel (37,2%). Diabetic status of the patients was assessed with HbA1c. TIMI flow grade and TIMI frame count were calculated and compared between two groups.Results. TIMI flow grade 3 was higher and TFC was lower after percutaneous coronary intervention of the infarct-related artery in patients treated with ticagrelor compared to clopidogrel (89,2% vs. 73,7%; p< 0,001, 20 vs. 24; p< 0,001). There was a positive correlation between the increases in HbA1c and TFC levels in the whole group (r=0,225; p=0,004). In subgroup analysis, higher HbA1c levels did not affect TFC in patients using ticagrelor (r=-0,060; p=0,326 for patients with noreflow, r=-0,133; p=0,321 for patients with TIMI-3 flow). While level of HbA1c did not affect TFC in patients with TIMI-3 flow, the presence of post-procedural no-reflow caused worsening of TFC in patients using clopidogrel as HbA1c levels increased (r=0,374; p=0,005).Conclusion. Ticagrelor was found to be better in terms of angiographic parameters regardless of diabetes.

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Study of Hba1c Levels in Acute Coronary Syndrome

Cited by 3 publications

References 12 publications

A study of the relation of HbA1c levels in acute coronary syndrome and its complications

A study of the relation of HbA1c levels in acute coronary syndrome and its complications

A Study on Glycaemic Status Impact in Acute Coronary Syndrome

The effect of ticagrelor and clopidogrel on angiographic parameters according to diabetic status in patients with ST elevation myocardial infarction

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