Study of haematological disorders detected by bone marrow examination at tertiary care hospital

Rathod, Kalpana B.; Wahane, Neeta; Nakate, Leena; Kulkarni, Deepak

doi:10.18231/j.jdpo.2019.038

Cited by 1 publication

(2 citation statements)

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“…2 Acute myeloid leukemia with 65 (26%) cases accounted for maximum of the cases followed by acute lymphoblastic leukemia with 64 (25.6%) cases which was in concordance with the study done by Rathod et al in which AML cases accounting maximum of the cases among acute leukemias. 6 Similar findings were also observed by Gupta et al 7 Among chronic leukemia, we encountered maximum of chronic myeloid leukemia (CML) with 40 (16%) cases followed by chronic lymphocytic leukemia with 17 (6.8%) cases. In the studies conducted by Piplani et al, Khatik et al, Atchyuta et al, Rana et al the most common disorder encountered was CML among chronic leukemia as in the present study.…”

Section: Discussionsupporting

confidence: 87%

“…12 Rathod et al also observed that maximum number of haematological disorders were in the age group of 21 to 30 years with male preponderance whereas Vahini et al in their study observed that most of the cases were in the age group of 46-60 years with male preponderance in contrast to our study. 6,13 Among 250 cases included in the study, 64 patients underwent simultaneous BMA and BMB. Majority of the cases showed positive correlation of 71.8% (46/64) between marrow aspiration and biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Utility of bone marrow aspiration and trephine biopsy in various haematological malignancies

Thakur

Thaker

et al. 2023

Int J Res Med Sci

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Background: The bone marrow examination is a useful and cost-effective diagnostic procedure in haematological practice for the diagnosis of haematological disorders. It may either confirm the clinically suspected disease or may provide the previously unsuspected diagnosis. The bone marrow examination can be done by bone marrow aspiration as well as by performing bone marrow biopsy. The aim of the study is to compare the diagnostic accuracy and rate of concordance between two modalities of bone marrow examination in diagnosis of haematological malignancies. Methods: The study was conducted at haematology section of the Department of Pathology, Government Medical College, Jammu spanned over a period of 2.5 years from June 2020 to December 2022. The clinical data along with physical examination, relevant haematological, biochemical and radiological investigations were also reviewed. After taking the informed consent bone marrow aspiration and bone marrow biopsy were done under aseptic precautions. Results: A total of 250 cases of haematological malignancies were studied over a 2.5 year period. The most common haematological malignancy was found to be leukemia 194 (77.6%) cases, followed by plasma cell dyscrasia with 30 (12%) cases, lymphomas and myeloproliferative disorders each with 11 (4.4%) cases and metastatic deposits 4 (1.6%) cases. In the present study, 64/250 (25.6%) patients underwent BMA and trephine biopsy simultaneously. A positive concordance was seen in 46 (71.8%) of the cases between the two methods and diagnostic discordance was observed in 10 (16.3%) of the cases. Conclusions: Bone marrow aspiration and biopsy both complement each other and should be evaluated simultaneously. This study emphasizes the need for greater vigilance in the early diagnosis and an interdisciplinary approach for the effective management of patients as well as inclusion of trephine biopsy as regular procedure for complete evaluation of patients with haematological malignancies.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%