Using data collected by the FOCUS experiment at Fermilab, we report the discovery of the decay modes D 0 → K − π + π + π + π − π − and D 0 → π + π + π + π − π − π − . With a sample of 48 ± 10 reconstructed D 0 → K − π + π + π + π − π − decays and 149 ± 17 reconstructed D 0 → π + π + π + π − π − π − decays, we measure the following relative branching ratios:The first errors are statistical and the second are systematic. The branching fraction of the Cabibbo suppressed six-body decay mode is measured to be a factor of two higher than the branching fraction of the Cabibbo favored six-body decay mode. 2004 Published by Elsevier B.V.