Study of gross mucosal findings of stomach in cases of fatal poisoning-An autopsy study

Aghera, V.J.; Pipaliya, Krunal N.; Dabhi, Dipen M.; Mangal, H.M.; Varu, Pratik R.; Manvar, Prince J.

doi:10.5958/2394-6776.2015.00007.7

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…This may be due to the fact that stomach being a reservoir, the contact period of poison with stomach is more. 12 In the present study, congestion was noted in more than 45% of cases which is in accordance to other studies, conducted elsewhere around the country. However, there are numerous factors that contribute to the stomach mucosal finding in poisoning cases.…”

Section: Various National and International Studiessupporting

confidence: 93%

Fatal Poisoning Cases in a Teaching Hospital of West Bengal: a Descriptive Cross-Sectional Clinico-epidemiological Study

Bhattacharjee¹,

Chatterjee²,

Hembram³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Poisoning is a global health issue and one of the leading causes of morbidity and mortality in India. Pattern of poisoning depends on factors, such as availability of poisons, socioeconomic status of the population, religious and cultural influences, thus creating varied epidemiological trends across time and regions. The present study is planned to address the epidemiological profiles of fatal poisoning cases, with reference to the gastric findings during autopsy.Methods: This is a descriptive, observational, cross-sectional study analysing 184 fatal poisoning cases, who attended to R.G. Kar Medical College Police Mortuary during the period of 2014-2015. Conclusion :People of age group 20-29 years were mostly affected, with a male preponderance and an incidence of 8.03%. People from the rural regions constituted more than 80% of the study sample, with suicide as the commonest manner of death. Organophosphorus compounds and acids were the mainly detected, with mucosal congestion and submucosal hemorrhage of stomach as the most reported findings. The authors feel that a prospective study is an option, which could accurately identify the cases and deaths, which could formulate stringent measures so as to decrease the morbidity and mortality due to poisoning.

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Section: Various National and International Studiessupporting

confidence: 93%

Fatal Poisoning Cases in a Teaching Hospital of West Bengal: a Descriptive Cross-Sectional Clinico-epidemiological Study

Bhattacharjee¹,

Chatterjee²,

Hembram³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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“…Macroscopic and microscopic autopsy findings in the lungs of those who died within the first 24 h after hospitalization were characterized by interstitial edema and hemorrhage in lungs [ 70 ] and tubular degeneration in the kidney (acute tubular necrosis); also, in those who died later after OP poisoning [ 75 , 76 , 77 , 78 , 79 , 80 ], the findings mostly resemble those observed in people who died of acute respiratory distress syndrome (ARDS) [ 81 , 82 ] of different causes, including viral infections of the upper respiratory tract [ 83 , 84 , 85 , 86 ] and also paraquat intoxication [ 87 ]. Similar histopathological (microscopic) changes can be induced in minipigs by bronchoscopic instillation of gastric juice containing OP (40% dimethoate 0.5 mL/kg) into the lung [ 88 ], simulating aspiration of gastric content, as may happen after ingestion of the insecticide mostly with suicidal intention.…”

Section: Organophosphorus Compounds As Insecticides and As Nerve Agentsmentioning

confidence: 99%

“…Autopsies are seldom performed in patients who died because of AOPP, and in most cases, it is related to the search for the toxic agent [ 77 , 78 , 79 , 80 , 81 , 82 ] and less to mechanisms that lead to death such as cardiac arrest, especially in persons of young age.…”

Section: Acetylcholinesterase and Albumin Measurement: Importance For...mentioning

confidence: 99%

Organophosphorus Poisoning: Acute Respiratory Distress Syndrome (ARDS) and Cardiac Failure as Cause of Death in Hospitalized Patients

Ramadori

2023

IJMS

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Industrial production of food for animals and humans needs increasing amounts of pesticides, especially of organophosphates, which are now easily available worldwide. More than 3 million cases of acute severe poisoning are estimated to occur worldwide every year, and even more cases remain unreported, while 200,000–350,000 incidentally or intentionally poisoned people die every year. Diagnostic and therapeutic procedures in organophosphate poisoning have, however, remained unchanged. In addition to several neurologic symptoms (miosis, fasciculations), hypersecretion of salivary, bronchial, and sweat glands, vomiting, diarrhea, and loss of urine rapidly induce dehydration, hypovolemia, loss of conscience and respiratory distress. Within hours, signs of acidosis due to systemic hypoxia can be observed at first laboratory investigation after hospitalization. While determination of serum-cholinesterase does not have any diagnostic value, it has been established that hypoalbuminemia alone or accompanied by an increase in creatinine, lactate, or C-reactive protein serum levels has negative prognostic value. Increased serum levels of C-reactive protein are a sign of systemic ischemia. Protective mechanical ventilation should be avoided, if possible. In fact, acute respiratory distress syndrome characterized by congestion and increased weight of the lung, accompanied by heart failure, may become the cause of death. As the excess of acetylcholine at the neuronal level can persist for weeks until enough newly, locally synthesized acetylcholinesterase becomes available (the value of oximes in reducing this time is still under debate), after atropine administration, intravenous albumin and fluid infusion should be the first therapeutic interventions to reestablish normal blood volume and normal tissue oxygenation, avoiding death by cardiac arrest.

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Study of gross mucosal findings of stomach in cases of fatal poisoning-An autopsy study

Cited by 2 publications

References 2 publications

Fatal Poisoning Cases in a Teaching Hospital of West Bengal: a Descriptive Cross-Sectional Clinico-epidemiological Study

Fatal Poisoning Cases in a Teaching Hospital of West Bengal: a Descriptive Cross-Sectional Clinico-epidemiological Study

Organophosphorus Poisoning: Acute Respiratory Distress Syndrome (ARDS) and Cardiac Failure as Cause of Death in Hospitalized Patients

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