Study of genetic diversity of KIR and TLR in the Rabhas, an endogamous primitive tribe of India

Guha, Pokhraj; Das, Avishek; Dutta, S.; Bhattacharjee, Soumen; Chaudhuri, Tapas Kumar

doi:10.1016/j.humimm.2015.09.024

Cited by 3 publications

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References 51 publications

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“…It is interesting to find that the genetic distance between Rajbanshi and Rabha is greater than the Rajbanshi–Gurkha and Rajbanshi–Muslim respectively. But, as per anthropological and genetic records, East Asian lineages have strong influence on the genetic ancestry of Rajbanshi, Rabha and Gurkha respectively [6], [9], [10] and Muslim population of this region showed their proximity with indigenous non Muslim population along with a small frequency of the Middle East ancestry [20], [7]. It was found that the Muslims, the Gurkhas and the Rajbanshis are the residents of the same locality and are therefore exposed to similar environmental effects.…”

Section: Discussionmentioning

confidence: 84%

“…However, the frequency of TLR4 was highest in Gurkha and Rabha populations. Previously TLR1 to TLR5 genes were screened among the Rabha population [10] where it was found that the frequency of TLR4 was calculated as highest and TLR5 was in least frequency. On the other hand, TLR5 was highest among Muslims (Communicated elswhere).…”

Section: Resultsmentioning

confidence: 99%

“…Sometimes polymorphism in the TLRs may also become susceptible or resistant to certain diseases [1], [15]. In our previous study, we found that chronic gastritis and associated stomach problems were common in Rabha population and therefore we speculated that there is a strong relationship between KIR and TLR in disease progression [10]. The genetic heterogeneity among the Indian populations have put forward an immense challenge before the researchers of different fields [20].…”

Section: Discussionmentioning

confidence: 98%

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Environmental selection influences the diversity of TLR genes in ethnic Rajbanshi population of North Bengal Region of India

Das

Guha

Chaudhuri

2016

Journal of Genetic Engineering and Biotechnology

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BackgroundToll-like receptors are the mediators of the innate immune response to pathogens. In human, this gene family regulates the inflammatory pathways and is associated with the susceptibility to infection.Subjects and methodsThe distribution and the diversity patterns of TLR genes in Rajbanshi population (n = 85) who are the inhabitants of the Northern part of West Bengal, have been investigated in the present study. PCR-SSP was done for all the ten TLR genes. We have also constructed the phylogenetic tree principal component analysis and genetic distance for all the four populations.ResultsIt has been observed that in Rajbanshi population, the frequency of TLR8 (0.894) is higher and the frequency of TLR2 (0.176) is very low. Dendrogram based analysis, as well as the PCA plot, documented the closeness of Rajbanshi and Gurkha population. However, Rabha is distantly related to Rajbanshi population though evidences suggest their emergence from the same East-Asian lineage. Genetic distances between Rajbanshi–Gurkha and Rajbanshi–Muslim are very much smaller than that of Rajbanshi–Rabha populations.Interpretations & conclusionsTherefore, it may be concluded that Rajbanshi, Gurkha and Muslims are very much mixed populations and have genetic closeness due to exposure to similar environmental conditions. On the other hand, the Rabhas strictly follow the endogamy and are restricted to a particular region and therefore maintain considerable distances with the other three populations. The data showed some interesting observations which deviate the contemporary thought in respect to the population genetics.

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Section: Discussionmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

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Environmental selection influences the diversity of TLR genes in ethnic Rajbanshi population of North Bengal Region of India

Das

Guha

Chaudhuri

2016

Journal of Genetic Engineering and Biotechnology

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Earth Mover’s Distance-Based Automated Disease Tagging of Indian ECGs

Basha¹,

Nandi²,

Kaur³

et al. 2022

Lecture Notes in Networks and Systems

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Genomics of rare genetic diseases—experiences from India

Sivasubbu

Scaria

2019

Hum Genomics

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Home to a culturally heterogeneous population, India is also a melting pot of genetic diversity. The population architecture characterized by multiple endogamous groups with specific marriage patterns, including the widely prevalent practice of consanguinity, not only makes the Indian population distinct from rest of the world but also provides a unique advantage and niche to understand genetic diseases. Centuries of genetic isolation of population groups have amplified the founder effects, contributing to high prevalence of recessive alleles, which translates into genetic diseases, including rare genetic diseases in India. Rare genetic diseases are becoming a public health concern in India because a large population size of close to a billion people would essentially translate to a huge disease burden for even the rarest of the rare diseases. Genomics-based approaches have been demonstrated to accelerate the diagnosis of rare genetic diseases and reduce the socio-economic burden. The Genomics for Understanding Rare Diseases: India Alliance Network (GUaRDIAN) stands for providing genomic solutions for rare diseases in India. The consortium aims to establish a unique collaborative framework in health care planning, implementation, and delivery in the specific area of rare genetic diseases. It is a nation-wide collaborative research initiative catering to rare diseases across multiple cohorts, with over 240 clinician/scientist collaborators across 70 major medical/research centers. Within the GUaRDIAN framework, clinicians refer rare disease patients, generate whole genome or exome datasets followed by computational analysis of the data for identifying the causal pathogenic variations. The outcomes of GUaRDIAN are being translated as community services through a suitable platform providing low-cost diagnostic assays in India. In addition to GUaRDIAN, several genomic investigations for diseased and healthy population are being undertaken in the country to solve the rare disease dilemma. In summary, rare diseases contribute to a significant disease burden in India. Genomics-based solutions can enable accelerated diagnosis and management of rare diseases. We discuss how a collaborative research initiative such as GUaRDIAN can provide a nation-wide framework to cater to the rare disease community of India.

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Study of genetic diversity of KIR and TLR in the Rabhas, an endogamous primitive tribe of India

Cited by 3 publications

References 51 publications

Environmental selection influences the diversity of TLR genes in ethnic Rajbanshi population of North Bengal Region of India

Environmental selection influences the diversity of TLR genes in ethnic Rajbanshi population of North Bengal Region of India

Earth Mover’s Distance-Based Automated Disease Tagging of Indian ECGs

Genomics of rare genetic diseases—experiences from India

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