Study of freshly excised brain tissues using terahertz imaging

Oh, Seung Jae; Kim, Sang Hoon; Ji, Young Bin; Jeong, Kyu Shik; Park, Yeonji; Yang, Jaemoon; Park, Dong Woo; Noh, Sam Kyu; Kang, Seok‐Gu; Huh, Yong Min; Son, Joo‐Hiuk; Suh, Jin Suck

doi:10.1364/boe.5.002837

Cited by 159 publications

(126 citation statements)

References 19 publications

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“…The results in Fig. 6 show the significant absorption of water that will be present in fresh tissue and will play a role in THz image contrast, in agreement with [8,10,15]. Fresh bovine tissue of size ~3.5 cm × 3.5 cm × 2.5 cm is scanned to obtain peak time domain, magnitude, and phase THz images.…”

Section: Animal Tissue Spectroscopysupporting

confidence: 79%

“…As a result, THz imaging has shown promise in assessment of burns [9], liver cirrhosis [10], and tissue damage from myocardial infarction [11]. Most notably, THz imaging has been applied to detecting and assessing regions of cancer in healthy tissue for a wide range of cancers including cancer of the skin [12,13], liver [11], colon [14], brain [15], and breast [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…A published study investigating THz interaction with DNAs, RNAs, proteins, biological liquids, and cellular structure or density demonstrated that THz contrast can be achieved without water presence [10,27]. The THz contrast is expected to increase by four times with the water content in fresh tissue [15].…”

Section: Introductionmentioning

confidence: 99%

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Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Bowman

El-Shenawee

Campbell

2016

Biomed. Opt. Express

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This work presents experimental and analytical comparison of terahertz transmission and reflection imaging modes for assessing breast carcinoma in excised paraffinembedded human breast tissue. Modeling for both transmission and reflection imaging is developed. The refractive index and absorption coefficient of the tissue samples are obtained. The reflection measurements taken at the system's fixed oblique angle of 30° are shown to be a hybridization of TE and TM modes. The models are validated with transmission spectroscopy at fixed points on fresh bovine muscle and fat tissues. Images based on the calculated absorption coefficient and index of refraction of bovine tissue are successfully compared with the terahertz magnitude and phase measured in the reflection mode. The validated techniques are extended to 20 and 30 μm slices of fixed human lobular carcinoma and infiltrating ductal carcinoma mounted on polystyrene microscope slides in order to investigate the terahertz differentiation of the carcinoma with non-cancerous tissue. Both transmission and reflection imaging show clear differentiation in carcinoma versus healthy tissue. However, when using the reflection mode, in the calculation of the thin tissue properties, the absorption is shown to be sensitive to small phase variations that arise due to deviations in slide and tissue thickness and non-ideal tissue adhesion. On the other hand, the results show that the transmission mode is much less sensitive to these phase variations. The results also demonstrate that reflection imaging provides higher resolution and more clear margins between cancerous and fibroglandular regions, cancerous and fatty regions, and fibroglandular and fatty tissue regions. In addition, more features consistent with high power pathology images are exhibited in the reflection mode images.

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Section: Animal Tissue Spectroscopysupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Bowman

El-Shenawee

Campbell

2016

Biomed. Opt. Express

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“…Second, the structural changes in afected tissues can also be an important sign for diagnosis and can be observed by THz imaging. As another example, a relection THz imaging system is used to identify tumors in freshly excised whole brain tissue from normal brain tissue based on structural observation [60]. Because the THz relection intensity is higher in brain tumors than in normal tissue, the diference in the THz relection intensity between the normal and tumor brain tissues can be adopted for the diagnosis of cancer.…”

Section: Studies Of Cancer By Thz Imaging or Spectroscopy Have Gainedmentioning

confidence: 99%

Terahertz Pulse Detection Techniques and Imaging Applications

Chen¹,

Guo²

2017

Terahertz Spectroscopy - A Cutting Edge Technology

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Recent years have witnessed successful developments of detection techniques of teraherz (THz) pulse radiation and its imaging applications such as security, medicine and environmental sensing, to name an important few. Progress of detection techniques has been made in many aspects, including detection sensitivity, real-time detection, roomtemperature operation, detection bandwidth and dynamic range, spatial (wavefront) and temporal proiles and so on. New detection techniques utilizing cuting-edge materials, sensors, systems and even novel detection mechanisms contribute to advances in teraherz pulse detection. While detection techniques continuously improve, teraherz pulsed imaging (TPI) also inds broad and intriguing applications. For instance, TPI has shown applications in nondestructive evaluation in pharmaceutics, biomedical characterization of tissues, medical diagnosis of cancers, identiication of explosive hazards and examination of art and archeology. The chapter highlights recent progress of teraherz pulse detection techniques and imaging applications.

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“…Terahertz (THz) electromagnetic waves are highly sensitive to biomolecules and water; they have been applied to many biomedical applications [7][8][9][10][11][12] including diagnosing various types of cancer [13][14][15][16][17]. The fundamental reason for the use of THz waves in cancer diagnosis is that they sensitively interact with water molecules.…”

Section: Introductionmentioning

confidence: 99%